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Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same

a radioisotope and radioisotope technology, applied in the direction of filtration separation, alkali metal sulfites/sulfates, separation processes, etc., can solve the problems of increasing the cost of production, reducing the yield, and increasing the difficulty of production of high-quality radioactive zirconium molybdate gel on a commercial scale through so many steps, etc., to achieve excellent physical stability, stable physical properties, and high adsorption performan

Inactive Publication Date: 2009-11-12
KOREA ATOMIC ENERGY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0017]Leading to the present invention, intensive and thorough research into the development of adsorbents having stable physical properties and high adsorption performance, carried out by the present inventors aiming to solve the problems encountered in the related art, resulted in the finding that sulfated alumina and alumina-sulfated zirconia have excellent physical stability, may be loaded in a dry state in a column, and have high adsorption capacity for molybdenum or tungsten, and thus may be used as high-performance adsorbents for radioisotope generators.

Problems solved by technology

However, the fission of 235U is disadvantageous because gases and solid radioactive materials are produced in large amounts, undesirably causing waste disposal problems which are burdensome and incur high costs.
However, because the method of preparing the zirconium molybdate gel includes a plurality of steps of forming the slurry, adjusting the pH, filtering the slurry, conducting washing and drying, and crushing the resultant precipitate to a preferred particle size, it is technically difficult to produce high-quality radioactive zirconium molybdate gel on a commercial scale through so many steps, and the method is thus undesirable.
Further, upon the preparation of 188W, 186W needs to be subjected to two neutron capture reactions, leading to further decreased yield.
However, the manufacture of the generator column using the above material suffers in that molybdenum is prepared in a batch type and the solution should be heated for a long period of time for the batch reaction, and thereby complicated radiations are required, and furthermore, even if the column is manufactured, the operating performance thereof is deteriorated.

Method used

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  • Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same
  • Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same
  • Adsorbents for Radioisotopes, Preparation Method Thereof, and Radioisotope Generators Using the Same

Examples

Experimental program
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Effect test

example 1

Preparation of Sulfated Alumina 1

[0062]In a vessel, 7.64 of ASB was dissolved in 15 of octanol, slowly added with 0.58 of anhydrous sulfuric acid with stirring for 10 min, and was then reacted for 2 hours. The solution thus obtained was slowly added with a solution comprising 0.65 of 0.14 M hydrochloric acid and 1.94 of ethanol, allowed to stand at room temperature for 24 hours, washed with acetone and ethanol in turn, and dried at 90° C. for 24 hours, thus obtaining a ceramic material composed of milk-white or light brown particles. The material thus obtained was dried, powdered using a mortar and pestle, boiled along with acetone, dried at 80° C. for 24 hours, and then stored in a sealed state.

example 2

Preparation of Sulfated Alumina 2

[0063]In a vessel, 7.64 of ASB was dissolved in a mixture comprising 5 of ethanol and 10 of octanol, slowly added with 0.58 of anhydrous sulfuric acid with stirring for 10 min, and then reacted for 20 min. In another vessel, 0.65 of 0.14 M hydrochloric acid was added to 1.94 of ethanol and then stirred. Thereafter, the reacted ASB solution was slowly added with the solution comprising hydrochloric acid and ethanol, allowed to stand at room temperature for 24 hours, and then dried at 90° C. for 24 hours, thus obtaining a ceramic material composed of milk-white or light brown particles. The material thus obtained was powdered using a mortar and pestle, washed with acetone and ethanol in turn, dried at 90° C. for 24 hours, and then stored in a sealed state.

example 3

Preparation of Sulfated Alumina 3

[0064]In a vessel, 7.94 of ASB was dissolved in 4.5 of isobutanol, slowly added with 4.5 of ethanol with stirring for 10 min, slowly added with 0.58 of anhydrous sulfuric acid with stirring for 1 hour, and then reacted for 1 hour. In another vessel, 0.54 of 0.14 M hydrochloric acid was added to 1.62 of ethanol and then stirred. Thereafter, the reacted ASB solution was slowly added with the solution comprising hydrochloric acid and ethanol, allowed to stand at room temperature for 24 hours, and dried under conditions of 80° C. for 24 hours, 130° C. for 24 hours, and 150° C. for 24 hours, thus obtaining a ceramic material composed of milk-white or light brown particles. The material thus obtained was powdered using a mortar and pestle, washed with acetone, boiled with acetone, dried at 80° C. for 24 hours, and then stored in a sealed state.

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Abstract

Disclosed is a novel adsorbent for use in a 99Mo / 99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W / 188Re generator, which is a therapeutic radioisotope generator. The adsorbent composed of sulfated alumina or alumina-sulfated zirconia exhibits adsorption capacity superior to that of conventional adsorbents, and is stable and is thus loaded in a dry state in an adsorption column so that the radioisotope 99Mo or 188W can be adsorbed. Thus, it is possible to miniaturize the column, and such a miniaturized column is small, convenient to use, and highly efficient, and extracts a radioisotope satisfying the requirements for pharmaceuticals, and thus can be useful for radioisotope generators extracting 99mTc or 188Re.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention relates to a novel adsorbent for use in a 99Mo / 99mTc generator, which is a medical diagnostic radioisotope generator, and in a 188W / 188Re generator, which is a therapeutic radioisotope generator.[0003]2. Description of the Related Art[0004]Tedlnetium-99m (99mTc), which is a very important radioisotope in the medical field, has been used for various types of medical diagnosis. 99mTc, acting as a γ-ray emitter having a half life of 6 hours, is the daughter radionuclide of molybdenum-99 (99Mo), which is produced through neutron absorption or fission of molybdenum-98 (98Mo), and is useful for medical diagnosis of incurable diseases, such as cancers and cardiac diseases.[0005]In addition to the diagnostic use, recently, as an interest is taken on therapeutic radiopharmaceuticals, 188Re is receiving attention as an attractive therapeutic nuclide.[0006]188Re is used for various therapeutic purposes includ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C01F7/74C01G25/06C01F7/02C01G25/02B01D39/20
CPCB01J20/0211B01J20/06B01J20/08B01J20/284G21G2001/0073B01J2220/56G21G1/001G21G2001/0042B01J2220/42
Inventor LEE, JUN SIGHAN, HYON SOOPARK, UL JAESON, KWANG JAESHIN, HYEON YOUNGHONG, SOON BOGJANG, KANG DUKLEE, JONG SUB
Owner KOREA ATOMIC ENERGY RES INST
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