Preparation method and anti-tumor medicine containing nano scheelite

An anti-tumor drug, scheelite technology, applied in the field of medicine, can solve the problems of single drug delivery method and difficult synthesis of polymers, and achieve the effect of stable material, simple method and remarkable application effect

Inactive Publication Date: 2007-07-11
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to provide a method of nanometer scheelite mixed with europium antitumor drug, which solves the problems of difficult synthesis of high polymer and single administration method, and has the characteristics of being slightly soluble in water and can form a sol state in DMSO

Method used

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  • Preparation method and anti-tumor medicine containing nano scheelite

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Experimental program
Comparison scheme
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Embodiment 1

[0017] 1. Mix 1g(NH4) 2 WO 4 Dissolve in 5ml ethylene glycol, and add 0.1gCTAB; dissolve 0.5g calcium acetate in 5ml ethylene glycol; take 5ml 0.1mol / L Eu(NO 3 ) 3 solution.

[0018] 2. Mix the above three solutions, and mix and react at 60°C for 10 minutes.

[0019] 3. Put the mixture into a polytetrachlorethylene pressure solution bomb and react at 110°C for 4 hours.

[0020] 4. Cool at room temperature for 12 hours, and filter to obtain the intermediate product.

[0021] 5. Take out and filter the obtained precipitate, put it into an oven for heat treatment at 110°C for 4 hours, and then put the obtained solid into a vacuum electric furnace for heat treatment at 600°C for 2 hours.

[0022] 6. Grind the solid obtained in the above steps for 30 minutes to obtain scheelite-doped europium nanopowder.

[0023] 7. Put the scheelite-doped europium nano-powder into DMSO (dimethyl sulfoxide) to prepare a sol with a concentration of 50 μg / ml, which is the nano-scheelite-doped e...

Embodiment 2

[0025] 1~6 steps are with embodiment 1;

[0026] The 7th step is to make the scheelite-doped europium nano-powder into an aqueous solution with a concentration of 50 μg / ml, which is the nano-scheelite-doped europium antitumor drug.

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Abstract

The invention relates to a method for using ammonium tungstate to prepare scheelite europium nanometer anti-cancer drug, wherein it comprises that: preparing (NH4)2WO4 solution as 14. 0%-16. 5%; adding 0.9-1. 1g cetyl trimethyl ammonium bromide; preparing 6. 5-10.0% calcium acetate solution; taking 4-6ml 0.1mol / L Eu(NO3)3 solution; mixing said three solutions; putting mixture into ankilostin pressure solution; reacting at 100-120Deg. C for 200-300min; laying for 10-14h at room temperature; filtering to obtain middle product; taking out and filtering to obtain deposits; putting into oven to be treated at 100-120Deg. C; putting solid into vacuum electric furnace to be treated at 550-650Deg. C; obtaining scheelite europium nanometer powder; putting it into dimethylene alum to prepare 1-100 mug / ml gel, as scheelite europium nanometer anti-cancer drug. The invention has simple method and simple control.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular provides a method for preparing nanometer scheelite-doped europium antitumor drugs by utilizing ammonium tungstate. Background technique [0002] Scheelite doped with europium has both fluorescence effect and antitumor activity. Thirty to forty kinds of polyoxometalates with anti-tumor activity have been found, most of which are heteropolytungstates or tungstomolybdates, and they are all water-soluble polymers. Nano scheelite doped with europium anti-tumor nano material is a mixed phase containing europium tungstate as the main structure of oligomer scheelite, which is dissolved in DMSO (dimethyl sulfoxide) to become a sol-state anti-tumor drug. Contents of the invention [0003] The purpose of the present invention is to provide a method of nano-scheelite doped with europium anti-tumor drugs, which solves the problems of difficult synthesis of high polymers and single admin...

Claims

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Application Information

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IPC IPC(8): A61K33/24A61K9/00A61K9/08A61P35/00C01G41/00
Inventor 曹林羊富强赵婕曹丽曹洁馨冯朝源
Owner UNIV OF SCI & TECH BEIJING
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