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Slow released capsule of amphotericin B and bletilla tuber glue for animal and birds

A technology of amphotericin and sustained-release capsules, which is applied in drug delivery, plant raw materials, organic active ingredients, etc. It can solve problems such as unsatisfactory adhesion and drug release performance, threat of dangerous diseases, and unsatisfactory safety. To achieve the effect of improving drug treatment effect, good therapeutic effect and improving bioavailability

Inactive Publication Date: 2007-06-27
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues
Natural materials are non-toxic and have good biocompatibility, but their adhesion and drug release properties are not ideal; synthetic materials have better adhesion and drug release properties, but are expensive and unsatisfactory in safety
Therefore, currently few bioadhesive materials fully meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of amphotericin B and Bletilla gum bioadhesive sustained-release capsules

[0014] a. Preparation of Bletilla striata gum: 5kg Bletilla striata, crushed, added 35L of distilled water, heated in a water bath at 60°C, soaked and stirred, the extract is filtered through four layers of gauze, and the dregs are added with distilled water. Repeat the dipping, combine the filtrate several times, and concentrate. Add 95% ethanol to make the alcohol content reach 70%, and a large amount of white flocculent precipitate is deposited. Let it stand overnight, filter the next day, recover the ethanol, collect the precipitate, wash 3 times with ethanol, evaporate the ethanol, and dry at about 80°C , Weighing, smashing, you can get Bletilla striata gum 1.0kg; Bletilla striata gum: It is yellow dry powder, tasteless and odorless, insoluble in ethanol, soluble in water, and a thick gel. α-Naphthol concentrated sulfuric acid and alkaline copper tartrate test solution sh...

Embodiment 2

[0016] Example 2: The prepared amphotericin B and Bletilla gum bioadhesive sustained-release capsules are used to treat various infections of livestock and poultry caused by fungi. The method of administration is mixing or drinking water, 0.008-0.03g / kg body weight of livestock and poultry, twice a day, 3-5 days as a course of treatment.

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PUM

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Abstract

The present invention belongs to the field of veterinary medicine technology, and is especially slow released veterinary medicine capsule prepared with amphotericin B and bletilla tuber as material. The preparation process includes the following steps: water extracting and alcohol precipitation to extract bletilla tuber glue; mixing amphotericin B and bletilla tuber in the ratio of 1 to 3 and 10 % concentration alcohol solution of PVP as adhesive; making pellet of 20 meshes and encapsulating. The slow released veterinary medicine capsule has long medicine retaining time in the disease focus, high local medicine concentration, excellent bioadhesion and obvious medicine slow releasing characteristic.

Description

Technical field [0001] The present invention belongs to the technical field of veterinary drugs, and particularly relates to the preparation of veterinary drug amphotericin B and Bletilla striata bioadhesive sustained-release capsules and a preparation method thereof. Background technique [0002] With the development of animal husbandry in our country in the direction of intensive and intensive, the scale of animal husbandry is constantly expanding, and ensuring the quality and safety of animal husbandry products has become an important issue we need to solve at present. At present, the main problems in my country's animal products are: first, the threat of dangerous diseases; second, drug residues. Among them, drug residues in animal food have endangered people's health. Therefore, the rational use of animal veterinary drugs and health products to control epidemics and drug residues in the production process of animal husbandry is an important issue that needs to be resolved. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K9/52A61K47/36A61K31/7048A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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