Chinese medicinal effective parts for treating nasal inflammation and preparation process thereof

An effective part and technology of traditional Chinese medicine, applied in the effective part of traditional Chinese medicine for treating nasal cavity inflammation and its preparation field, can solve the problems of obvious side effects, unclear ingredients, low content, etc., and achieve the effect of good safety, good effect and significant therapeutic effect

Inactive Publication Date: 2007-05-23
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] But at present, Zicao bubble preparation is used to treat rhinitis, and there are mainly the following deficiencies: (1) nasal drip after soaking Zicao in white wine is very irritating to nasal mucosa, and the side effect is obvious; (2) the ingredients are unclear and the content is not high; (3) ) cannot carry out quality control, and the curative effect cannot be guaranteed; (4) cannot carry out large-scale promotion

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0084] Embodiment 1: the preparation of this product extract

[0085] Recipe Comfrey 20kg

[0086] The preparation method is to crush comfrey into coarse powder, put it into a percolation column, add 5 times the amount of 85% ethanol to soak for 8 hours, then add 10 times the amount of 85% ethanol to percolate, recover ethanol from the percolation solution, and add alkaline water to the aqueous solution. Approximately alkaline, add alkaline water while stirring until the hydrolysis is complete, filter, adjust the filtrate to approximately acidic with acid, stir thoroughly, let it stand overnight, filter, collect the precipitate, wash the precipitate with water until neutral, dry, and pulverize. Obtain 123.5g dry powder of the extract.

[0087] Determination of the content of total naphthoquinone in the extract

[0088] The content determination method of the total naphthoquinone of Shikoni refers to the determination method of the total naphthoquinone of Shikoni in the 2005 ...

Embodiment 2

[0096] The dried comfrey extract obtained in Example 1 was dissolved with 95% ethanol, applied to a macroporous resin, eluted with acetone, acetone was recovered, dried, and pulverized to obtain a powder extract (effective part of comfrey). Measured by the assay method of Implementation 1, the total total naphthoquinones (pigments) of the comfrey are more than 75%.

Embodiment 3

[0097] Embodiment 3: the preparation of gel

[0098] formula

[0099] Comfrey Extract Dry Powder 0.75g Glycerin 100.0g Carbomer-940 10.0g

[0100] Triethanolamine 10.0g Polysorbate-80 10.0g 95% ethanol in proper amount

[0101] Ethyl p-hydroxybenzoate 0.5g, appropriate amount of menthol, add purified water to 1000.0g

[0102] Put glycerin in a mortar, add Carbomer-940, fully grind to make it moist, add about 600ml of purified water, grind to make it fully swell, add polysorbate-80 and p-hydroxybenzoic acid dissolved in an appropriate amount of ethanol Ethyl ester and menthol, grind well; then slowly add the dry powder of comfrey extract dissolved in an appropriate amount of ethanol, grind while adding, and disperse evenly, add triethanolamine, stir while adding, make a gel, add purified water To the full amount, stir well, sub-package, that is.

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PUM

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Abstract

The invention relates to a method for preparing traditional medicine effective component and relative composite, which can treat nasal disease, wherein said component comprises more than 50% of alkanna tinctoria naphthaquinones of alkanna tinctoria. And the preparation comprises that: extracting alkanna tinctoria, recycling alcohol, treating solution with resin, acid, alkali, drying, and breaking; mixing findings, checking and packing. The inventive drug can treat kinds of nasal diseases.

Description

technical field [0001] The invention belongs to the field of effective parts of traditional Chinese medicine, and in particular relates to an effective part of traditional Chinese medicine for treating nasal cavity inflammation and a preparation process thereof. Background technique [0002] Comfrey (Radix Arnebiae, Radix lithospermi) is a commonly used Chinese herbal medicine in my country. It has the effects of cooling blood, promoting blood circulation, detoxification and rash. "Compendium of Materia Medica" date: Comfrey "cures macule and pox, activates blood and cools blood, and benefits large intestine." Studies have shown that comfrey has anti-pathogenic microorganisms, anti-inflammatory and anti-allergic, antipyretic, anti-tumor, liver protection, and hemostasis. , hypoglycemic, sedative and affect immune function. Its main component, shikonin, is one of the five natural plant red pigments commonly used in the world with the best performance. It has been included i...

Claims

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Application Information

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IPC IPC(8): A61K36/30A61K9/00A61K9/08A61K9/12A61P11/02
Inventor 陈伟海韩宪忠刘泽荣
Owner CHONGQING PHARMA RES INST
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