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Blood stream-breaking dispersing tablets

A blood-cutting and dispersible tablet technology, which is applied in the field of blood-breaking dispersible tablets, can solve problems such as difficult industrialization, adhesion, and high proportion content, and achieve the effect of large room for maneuver and improved disintegration

Inactive Publication Date: 2007-04-04
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Most traditional Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. In addition, most of the traditional Chinese medicine extracts Macromolecular substances such as pectin and polysaccharides adhere to the surface of traditional Chinese medicine dispersible tablets when they disintegrate, causing negative effects on drug disintegration and dissolution
[0012] To sum up, most Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets within 3 minutes due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. It is more difficult to industrialize than western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Duanxueliu dispersible tablet: fine powder of Duanxueliu extract 20%, crospovidone 24%, sodium carboxymethyl starch 20%, microcrystalline cellulose 10%, lactose 20%, Polyvinylpyrrolidone 3%, Magnesium Stearate 3%.

[0054] Duanxueliu dispersible tablets are obtained according to the following specific steps: take Duanxueliu, cut into sections, decoct twice with water for 1.5 hours each time, combine the decoctions, filter, and concentrate the filtrate to a relative density of 1.15 (80°C), Add 1.7 times the amount of ethanol, stir well, let it stand for 24 hours, take the supernatant and concentrate it under reduced pressure to form a thick paste, dry it into a dry extract, and pulverize it to obtain a fine powder of the blood flow extract.

[0055] First pass the above-mentioned materials through a 100-mesh sieve, and mix the fine powder of the broken blood flow extract with the mix...

Embodiment 2

[0057] 30% by weight of fine powder of broken blood extract, 20% sodium carboxymethylcellulose, 12% microcrystalline cellulose, 16% cross-linked polyvinylpyrrolidone, 5% polyvinylpyrrolidone, 10% lactose, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0059] 36% by weight of fine powder of broken blood extract, 20% sodium carboxymethyl starch, 15% croscarmellose sodium, 6% crospovidone, 3% low-substituted hydroxypropyl cellulose , mannitol 9%, polyvinylpyrrolidone 7%, calcium stearate 2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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Abstract

A dispersing tablet of Herba clinopodii for treating functional metrorrhagia, menorrhagia, postpartum hemorrhage, hysteromyoma hemorrhage, nosebleed, purpura simplex, primary thrombocytopenic purpura, etc is prepared from Herba clinopodii and proper additives.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a dispersible tablet for cutting off blood flow. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. There are many dosage forms of Duanxueliu, which have the effect of cooling blood and stopping bleeding. For functional uterine bleeding, menorrhagia, postpartum hemorrhage, uterine fibroids, hematuria, hematochezia, hematemesis, hemoptysis, epistaxis, simple purpura, idiopathic thrombocytopenic purpura, etc. Duanxueliu, one of the original dosage forms, is a sugar-coated tablet that has been included in the Chinese Pharmacopoeia. Duanxueliu sugar-coated tablets have slow dissolution, poor absorption and low bioavailability. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less th...

Claims

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Application Information

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IPC IPC(8): A61K36/53A61K47/38A61K9/20A61P7/04A61P15/00
Inventor 罗晓健杨世林吕爱平王金钱傅国强张爱玲张红红
Owner JIANGXI HERBFINE HI TECH
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