Dispersing tablets against cervicitis

A technology for anti-uterine inflammation and dispersible tablets, which is applied in the direction of medical preparations containing active ingredients, plant/algae/fungus/moss components, plant raw materials, etc., and can solve the negative effects of adhesion, difficult industrialization, drug disintegration and dissolution and other problems, to achieve the effect of improving disintegration and large room for maneuver

Inactive Publication Date: 2007-04-04
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Most traditional Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. In addition, most of the traditional Chinese medicine extracts Macromolecular substances such as pectin and polysaccharides adhere to the surface of traditional Chinese medicine dispersible tablets when they disintegrate, causing negative effects on drug disintegration and dissolution
[0011] To sum up, most Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets within 3 minutes due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. It is more difficult to industrialize than western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The traditional Chinese medicine raw materials of Kanggongyan Dispersible Tablets: 167g of Guangdong Zizhu dry extract, 44g of motherwort dry extract, and 39g of Wuyao dry extract.

[0054] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Kanggongyan Dispersible Tablets: 26% of fine powder of Kanggongyan extract, 20% of pregelatinized starch, 30% of microcrystalline cellulose, 8% of low-substituted hydroxypropyl cellulose, Mannitol 10%, polyvinylpyrrolidone 4%, micronized silica gel 1%, magnesium stearate 1%.

[0055] Kanggongyan Dispersible Tablets are obtained according to the following specific steps: take Guangdong Zizhu, moisten thoroughly, cut into small pieces or original pieces, add water and decoct twice, the first time for 3 hours, the second time for 2 hours, combine the decoction, filter After drying, the filtrate was concentrated to a thick paste, and dried under reduced pressure to obtain Guangdong Zizhu dry extract;...

Embodiment 2

[0058] 38% by weight of fine powder of anti-uterine extract, 20% sodium carboxymethylcellulose, 15% cross-linked polyvinylpyrrolidone, 8% microcrystalline cellulose, 5% polyvinylpyrrolidone, 7% lactose, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0060] 32% by weight of fine powder of anti-uterine extract, 21% sodium carboxymethyl starch, 18% croscarmellose sodium, 9% low-substituted hydroxypropyl cellulose, 3% cross-linked polyvinylpyrrolidone , mannitol 6%, polyvinylpyrrolidone 7%, micronized silica gel 2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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PUM

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Abstract

A 'Kanggongyan' dispersing tablet for treating chronic cervicitis, cervical erosion, metrorrhagia, morbid leukorrhea, etc is prepared from beautyberry leaf, motherwort, lindera root, and proper auxiliary.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a dispersible tablet for anti-uterine inflammation. Background technique [0002] Dispersible tablets are a new dosage form of medicine developed in recent years. There are many dosage forms for anti-uterine inflammation, which have the functions of clearing away dampness and heat and stopping leukorrhea. It is used for damp-heat injections caused by chronic cervicitis, red and white vaginal discharge, cervical erosion, bleeding and other diseases. Kanggongyan sugar-coated tablets, one of the original dosage forms, have been listed in the Chinese Pharmacopoeia. Kanggongyan sugar-coated tablets have slow dissolution, poor absorption and low bioavailability. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less than 3 minutes, and al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K36/533A61K36/54A61K9/20A61P15/00
Inventor 罗晓健吕爱平王跃生张爱玲饶毅文毅游剑
Owner JIANGXI HERBFINE HI TECH
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