Liposome vitamin A acid aerosol for treating chronic obstructive pulmonary disease

Abstract

The invention relates to a bangosome retinoic acid aerosol which can prevent chronic obstructive pulmonary. The ingredients of the aerosol include: retinoic acid bangosome, cefepime or ceftazidime, fluormone or cetacort and distilled water. The mentioned retinoic acid bangosome is made of the following materials: 1-2 share (by weight) retinoic acid, 10-15 shares (by weight) cholesterol, 10-15 shares (by weight) lecithin and 0.01-0.2 VE. The producing procedures go as follows: mix 2-3 shares (by weight) retinoic acid bangosome with 0.1-0.2 cefepime or ceftazidime, 0.0005-0.0025 fluormone or 0.01-0.05 cetacort; add distilled water to the ingredients at the ratio of 1:15-1:20; fill the material into clean jars to get the aerosol.

Description

technical field [0001] The invention belongs to drugs for treating respiratory diseases, in particular to the application of retinoic acid in the preparation of drugs for chronic obstructive respiratory diseases. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a type of disease characterized by incompletely reversible airflow limitation of the airway, and its incidence is high and increasing year by year. Currently, COPD is the fifth most common disease. The lesions of COPD are mainly manifested as: due to the repeated stimulation of various pathogenic factors, airway epithelial cell cilia adhere, lodging and loss, followed by degeneration, necrosis, hyperplasia and metaplasia of epithelial cells, and finally mucociliary movement The system is compromised. [0003] The airway of normal people has a complete defense function, and the airway mucociliary motor system is at the core, in which ciliated columnar epithelial cells are the main cell co...

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Problems solved by technology

However, when theophylline drugs are used for the elderly and those with persistent fever, cardiac insufficiency, and poor liver function, they are prone to danger.

[0006] 2. β 2 Receptor stimulants such as salbutamol and bricanyl, beta 2 Receptors are mainly distributed in the small airways inhaled or administered beta 2 - After receptor agonists, the small airways can be significantly dilated, thereby reducing or relieving symptoms, but β 2 The side effect of receptor stimulants is dilation of bronchi and blood vessels at the same time, causing imbalance of lung ventilation / blood flow ratio; excessive application can cause tremors, palpitations, etc.

Although it has bronchial antispasmodic effect, its clinical application is limited due to side effects such as dry mouth, thick sputum that is difficult to spit out, and palpitations.

[0008] 4. Hormone such as prednisone, for COPD patients whose condition has not been improved or is tending to worsen after adequate bronchodilator treatment, it may be effective to add hormone therapy

But it can cause hypersecretion of sputum and aggravate dyspnea