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New type bracket material for tissue engineering of polypeptide nerve, preparation method and application

A nerve tissue and scaffold material technology, applied in the field of life sciences, can solve the problems of degraded products that are harmful to organisms, rarely have nerve tissue engineering, low bioavailability, etc., achieve no immune response and toxic response, and be easy to artificially design and modify. , the effect of simple reaction conditions

Inactive Publication Date: 2007-02-21
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Description
  • Claims
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Problems solved by technology

[0005] There are two types of scaffold materials currently used for neural tissue engineering: ① inorganic materials, which have high mechanical strength, poor viscoelasticity, and difficult biodegradation; they are rarely used in neural tissue engineering; ② organic polymer materials, which are bioavailable after degradation Low degree, or the degradation products are harmful to organisms and other disadvantages, mainly used to make catheters for peripheral nerves
The inherent shortcomings of the above two types of materials limit their application in central nervous tissue engineering (NerveTissue Engineering, NTE)

Method used

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  • New type bracket material for tissue engineering of polypeptide nerve, preparation method and application
  • New type bracket material for tissue engineering of polypeptide nerve, preparation method and application
  • New type bracket material for tissue engineering of polypeptide nerve, preparation method and application

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Embodiment Construction

[0041] The implementation of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0042] The novel polypeptide nerve tissue engineering scaffold material of the present invention, the polypeptide structural sequence is: C 16 h 31 O-Ala-Ala-Ala-Gly-Gly-Gly-Gly-Asp-Asp-Ile-lys-Val-Ala-Val-COOH. (Ala, A-alanine; Gly, G-arginine; Asp, D-aspartic acid; Ile, I-isoleucine; lys, K-lysine; Val, V-valine acid). abbreviated as C 16 h 31 O-A 3 G 4 D. 2 IKVAV.

[0043] The above-mentioned scaffold material for polypeptide nerve tissue engineering is prepared, which includes the following steps:

[0044] synthesis

[0045] The peptide chain was synthesized using the Fmoc / PyBOP method. Fmoc was decapped with 30% hexahydropyridine in DMF. Peptide cutting reagent (trifluoroacetic acid / silane / water=95 / 2.5 / 2.5) was used to cut off the peptide chain from the resin. Weigh 1000mg of Fmoc-Val-wang resin, and add various Fmoc-amino acid...

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Abstract

A polypeptide scaffold for the nervous tissue engineering has the structure: C16H31O- Ala-Ala-Ala-Gly-Gly-Gly-Gly-Asp-Asp-Ile-lys-Val-Ala-Val-COOH. Its advantages are high visoelasticity, easy injection to target site, high degradability and biologic utilization rate, and low toxic by-effect and immunoreaction. Its preparing process and its application in preparing medicines are also disclosed.

Description

technical field [0001] The invention belongs to the field of life sciences, and relates to a designed and synthesized novel polypeptide nerve tissue engineering scaffold material, its preparation method and its application in the treatment of spinal cord injury. Background technique [0002] Nervous system (nervous system, NS) due to lesions or injuries, lead to a large number of neurons degeneration and necrosis, axonal disintegration, inhibitory factors such as inflammatory factors, chondroitmase ABC (Chondroitmase ABC), etc. exist in large quantities, and nerve cells cannot Regeneration, soft tissue barriers, such as glial scars block neural pathway connections, so its therapeutic and rehabilitation effects are not ideal. [0003] Nerve tissue engineering includes three elements: ① scaffold material, ② seed cells, such as Schwann cells (SchwannCells, SCs), neural stem cells (Neural stem cells, NSCs), etc., ③ various cytokines or growth factors and signal peptides. The sc...

Claims

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Application Information

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IPC IPC(8): A61L27/22
Inventor 郑启新宋玉林吴永超郭晓东
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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