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Ginseng stem leaves general saponin freeze-drying powder injection and its preparation method

A technology for freeze-dried powder injection and ginseng stem and leaf, which is applied in freeze-dried delivery, medical preparations containing active ingredients, powder delivery, etc., can solve the problems of high price of ginseng, high price of ginseng injection products, and difficulty in storage, etc. Achieving the effect of cheap price, enhanced immunity and cost reduction

Inactive Publication Date: 2006-09-27
ZHUHAI TONGYUAN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It shows that it is not easy to preserve, and the price of ginseng as a raw material is high, and the price of ginseng injection products is also expensive

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] A kind of ginseng stem and leaf total saponins freeze-dried powder injection of this embodiment contains solid ginseng stem and leaf extract 6.7mg, auxiliary material mannitol 50mg, auxiliary material glucose 50mg and solid ginseng stem and leaf extract, auxiliary material mannitol, glucose total 2% moisture by weight. The weight ratio of the auxiliary material mannitol to the auxiliary material glucose is 1:1.

[0050] A preparation method of the freeze-dried powder injection of total saponins of ginseng stems and leaves for injection in this embodiment comprises the following steps:

[0051] (1) Prepare materials according to raw material solid ginseng stem and leaf extract 6.7mg, auxiliary materials mannitol 50mg, glucose 50mg, and sterilized water for injection 400000mg.

[0052] (2) Get 6.7 mg of solid ginseng stem and leaf extract, 50 mg of auxiliary material mannitol, and 50 mg of auxiliary material glucose, and put them into the batching tank, then add 200,000 ...

Embodiment 2

[0056] The freeze-dried powder of ginseng stem and leaf total saponins for injection in this embodiment contains 3 mg of solid ginseng stem and leaf extract, 10 mg of glycine or sodium glycinate as an auxiliary material, 15 mg of lactose or dextran as an auxiliary material, and solid ginseng stem and leaf extract, glycine or glycine as an auxiliary material. Sodium glycinate and auxiliary material lactose or dextran total weight 1% water.

[0057] The weight ratio of the auxiliary material glycine or sodium glycinate to the auxiliary material lactose or dextran is 1:1.5.

[0058] Its preparation method is to add 66666 mg of sterile water for injection to 3 mg of solid ginseng stem and leaf extract, 10 mg of auxiliary material glycine or sodium glycinate and 15 mg of auxiliary material lactose or dextran, and make the solid ginseng stem and leaf extract, auxiliary material glycine or sodium glycinate and auxiliary material lactose or After the dextran is dissolved, add solid gi...

Embodiment 3

[0061] A freeze-dried powder injection of ginseng stem and leaf total saponins for injection in this embodiment contains solid ginseng stem and leaf extract 13.3 mg, auxiliary materials mannitol 100 mg, auxiliary materials glucose 100 mg, solid ginseng stem and leaf extract, auxiliary materials mannitol, and auxiliary materials glucose 3.5% moisture by total weight.

[0062] The preparation method is to add 250,000 mg of sterilized water for injection to 13.3 mg of solid ginseng stem and leaf extract, 100 mg of auxiliary material mannitol, and 100 mg of auxiliary material glucose, dissolve the solid ginseng stem and leaf extract, auxiliary material mannitol, and auxiliary material glucose, and then add solid ginseng Activated carbon for needles with a total weight of stem and leaf extracts and auxiliary materials of 5‰, stirred at 40°C for 50 minutes, cooled to room temperature at 21°C, and adjusted the pH of the solution to 7 with 0.1 mol / liter of sodium hydroxide aqueous solu...

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Abstract

The present invention relates to freeze dried powder for injection with ginseng stem and leaf extract as main material and its preparation process. The freeze dried powder for injection may be used in treating coronary heart disease and climacteric syndrome, and can strengthen physique and strengthening immunity. It contains ginseng stem and leaf extract in 3-20 weight portions and supplementary material and water in 25-250 weight portions. The preparation process includes adding supplementary material and water into ginseng stem and leaf extract through stirring to dissolve, packing, and freeze drying via quick lowering temperature to -40 to -55 deg.c and pumping to 5-10 Pa, heating to 25-40 deg.c and maintaining for 5-20 hr. The preparation process has less damage of the effective medicine components and stable product quality, and the product has long preservation period and other advantages.

Description

technical field [0001] The invention relates to a preparation and a preparation method derived from ginseng stem and leaf extracts derived from plant materials, more specifically a freeze-dried powder injection made from ginseng stem and leaf extracts as raw materials and a preparation method thereof. Background technique [0002] Ginseng is the dried root of Araliaceae (Panax ginseng C.A.Mey). The cultivated ones are called "garden ginseng" and the wild ones are called "mountain ginseng". through". Ginseng has the functions of invigorating vital energy, recovering pulse and strengthening the spleen, nourishing the spleen and lung, promoting body fluid, and calming the nerves. It is used for physical weakness, cold limbs, slight pulse, spleen deficiency, lack of food, lung deficiency, wheezing and coughing, body thirst, internal heat disappearing, palpitations and insomnia, impotence, cold uterus, heart failure, and cardiogenic shock. [0003] Modern medical and pharmacolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/7048A61K9/19A61P1/14A61P9/04A61P9/02A61P11/00A61P25/20A61P15/10A61K127/00A61K135/00
Inventor 丁钉生
Owner ZHUHAI TONGYUAN PHARMA CO LTD
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