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Extraction of schizandrol A

A technology for the extraction process of schisandrin A, which is applied in ether separation/purification, ether preparation, organic chemistry, etc., can solve the problems of low purity of schisandrin A, complex extraction equipment, and high operating costs, and achieve strong adsorption specificity, Significant economic benefit and high purity effect

Inactive Publication Date: 2006-08-16
朱萧俊
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Problems solved by technology

Take the former medicine of Schisandrin A with a weight content of 0.4% as an example, (hereinafter the same) the extraction rate of extracting Schisandrin A from the former medicine of Schisandra is generally about 0.2%, but the purity is only about 2%, and the color to hazel
The other is a supercritical fluid extraction method, which uses CO to crush Schisandra chinensis 2 Supercritical equipment can be directly extracted to obtain schisandrin A. The extraction rate of schisandrin A in the original drug is close to 0.4%, but the purity is only about 10%, and the color is dark green.
At the same time, the extraction equipment is complicated, the investment is large, the operation requirements are strict, and the operating cost is high.
Combining the above two methods, their common defect is that the purity of the obtained schisandrin first is not high

Method used

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Experimental program
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Effect test

specific Embodiment approach 1

[0013] The specific embodiment 1 is a kind of extraction process of preferred schisandrin A, and its technological process is as follows:

[0014] 1. Grind 5000 grams of Schisandra chinensis produced in Gansu to 10-30 mesh, add 15 liters of 95% V / V edible ethanol (the same below), reflux in a reflux extraction tank for 120 minutes, cool to room temperature, and suction filter , and the filtrate was set aside.

[0015] 2. Add 10 liters of ethanol to the medicine dregs obtained by suction filtration, reflux for 120 minutes, cool to room temperature, perform a second suction filtration, and store the filtrate separately.

[0016] 3. Add 10 liters of ethanol to the dregs obtained by the second suction filtration, reflux for 120 minutes, cool to room temperature, and perform the third suction filtration. The anhydrous ethanol filtrates obtained three times were combined, the ethanol was recovered by distillation, and the filtrate was concentrated to obtain an extract of schisandri...

specific Embodiment approach 2

[0032] The difference between this embodiment and the specific embodiment 1 is that steps 8, 9, and 10 in the specific embodiment 1 are combined, and the others are the same, and the differences are specifically:

[0033] Set up 1 chromatographic column, directly go up this chromatographic column on the 300 gram mixtures that step 7 makes, eluent is sherwood oil and ethyl acetate, begins to collect when eluting to alcohol first appearance, collects until no In the case of alcohol form, the elution is stopped when it is collected until there is no alcohol form (judged by TLC thin-layer chromatography identification method). Get the eluent, which contains Schisandrin A.

[0034] Measured by the same method: weight: 19.1g, yield: 0.38%, purity: 48.7%.

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Abstract

Extraction of Schisandra chinensis alcohol-A is carried out by extracting Schisandra chinensis by solvent, extracting extract containing Schisandra chinensis alcohol-A, column chromatography separating, recovering elutropic solvent in eluent containing Schisandra chinensis alcohol-A and obtaining the final product concentrate. It is cheap and simple, has higher purity, recovery rate and quality.

Description

Technical field: [0001] The technical scheme to be protected by the present invention belongs to the technical field of extracting schisandrin A. Background technique: [0002] Schisandra chinensis includes various components such as schisandrin A, schisandrin B, schisandrin alcohol A, and schisandra alcohol B. Schisandra chinensis is commonly used in traditional Chinese medicine to astringe and solidify astringent, tonify qi and promote body fluid, tonify kidney and calm heart, relieve cough and calm down. Schisandra chinensis mainly contains volatile oil, lignans and other components. Schisandrin is an all-natural ingredient hidden in Schisandra chinensis. It belongs to lignan-like solid powder substances. "Chinese Pharmacopoeia" (a traditional Chinese medicine in 2000) It is stipulated that the weight content of schisandrol A in medicinal Schisandra chinensis is not less than 0.4%. As the purity increases, the color changes from dark to light until white powder. It has...

Claims

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Application Information

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IPC IPC(8): C07C43/253C07C41/38
Inventor 朱萧俊
Owner 朱萧俊
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