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New compound Chinese medicinal preparation for anti rheumatism and its preparation technology

An anti-rheumatic and traditional Chinese medicine technology, applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve problems that do not meet the needs of patients, are not suitable for the modernization of traditional Chinese medicine, and the development requirements of internationalization

Inactive Publication Date: 2006-06-14
南京宇道科技开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because pills and mixtures are old dosage forms of traditional Chinese medicine, there are many shortcomings, which do not meet the needs of patients today, and are not suitable for the development requirements of modernization and internationalization of traditional Chinese medicine.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] The prescription and preparation method of embodiment 1 soft capsule

[0079] Prescription 1: (1000 capsules)

[0080] Liquid material composition:

[0081] Medicinal volatile oil 10ml

[0082] Drug solid powder 200g

[0083] 5% Tween 80 0.1g

[0084] Hydroxylated Lecithin 5g

[0085] Beeswax 5g

[0086] PEG400 300g

[0087] water 60g

[0088] Shell material composition:

[0089] Gelatin 100g

[0090] Glycerin 38g

[0091] water 100g

[0092] Methyl sorbate 0.01g

[0093] Process steps:

[0094] 1) Weigh gelatin and add it to the gelatin reaction tank, add purified water with soluble gelatin amount unde...

Embodiment 2

[0126] The prescription and the preparation method of embodiment 2 dropping pills:

[0127] Prescription 1: (1000 capsules)

[0128] Medicinal extract 10g

[0129] PEG4000 40g

[0130] Condensate Methyl silicone oil

[0131] Preparation method: Add water to the medicinal extract to make a uniform paste, then add molten PEG4000, heat and melt to form a clear liquid, pour it into a preheated pill dropper, the dropping temperature is about 85°C, and the dropping speed is about 30 drops / min, drip into the condensate, collect the drop pills after pelleting, and put them in a desiccator for 24 hours.

[0132] Prescription 2: (1000 capsules)

[0133] Medicinal extract 10g

[0134] PEG6000 40g

[0135] Condensate Methyl silicone oil

[0136] Prescription 3: (1000 capsules)

[0137] Medicinal extract 10g

[0138] Glyceryl Stearate 40g

[0139] ...

Embodiment 3

[0140] The prescription and preparation of embodiment 3 tablet

[0141] Prescription 1 (1000 tablets):

[0142] Drug solid powder 200g

[0143] Drug β-cyclodextrin inclusion compound powder 10g

[0144] Microcrystalline Cellulose 200g

[0145] Sodium carboxymethyl starch 5g

[0146] Magnesium Stearate 1.5g

[0147] The preparation method is as follows:

[0148] 1. Preparation of clathrate: Accurately weigh 4.00g of β-cyclodextrin, add it to a 200ml conical flask with a stopper, add 100ml of water to dissolve it completely, and make a saturated solution of β-cyclodextrin, lower the temperature to 20°C , stirring at constant temperature. After diluting the volatile oil of the drug with absolute ethanol 1:2, slowly add it dropwise into the saturated solution of β-cyclodextrin with a syringe, keep the temperature and stir for 1 hour after sealing, place it in a refrigerator at 4°C for 24 hours, filter it with suctio...

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PUM

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Abstract

A Chinese medicine in the form of softgel, dripping pill, tablet, capsule, or particle for treating rheumatism is an improvement to the Chinese medicine í‹Danggui Zantong decoctioníŒ in such area that the volatile oil and the oily powder are used.

Description

Technical field: [0001] The invention belongs to the field of research and development of traditional Chinese medicines, and relates to a new anti-rheumatic traditional Chinese medicine compound preparation and a preparation method thereof, in particular to a new medicinal preparation of "Danggui Niantong Decoction" and a preparation process thereof. Background technique: [0002] "Bi syndrome" in traditional Chinese medicine refers to the main symptoms caused by wind, cold, dampness, heat and other exogenous evils attacking the human body, blocking the meridian, and poor circulation of Qi and blood, with pain as the main symptom, involving muscles, bones, and joints. It is a general term for diseases of tissues such as skin, blood vessels, etc. Its main clinical manifestations include pain, numbness, heaviness, difficulty in flexion and extension, and even swelling and burning of joints. The range of Bi syndrome in traditional Chinese medicine is relatively wide, such as rh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61K9/16A61K9/20A61K9/48A61P29/00
Inventor 史美耿阮锦满姚小燕郝静梅彭青
Owner 南京宇道科技开发有限公司
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