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Aucklandia root oil containing emulsion, its preparation process and use

A technology of wood balsam oil and emulsion, which can be applied to medical preparations containing active ingredients, anti-inflammatory agents, anti-viral agents, etc., can solve the problems of high incidence of allergic reactions and a large number of organic solvents, and achieve improved drug concentration and therapeutic effect. Enhanced, high content of active ingredients

Active Publication Date: 2006-05-10
SHANDONG LUYE PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Because woody oil is hydrophobicity, so preparation injection needs a large amount of organic solvents or uses the solubilizing agent of a large amount of toxic side effects, as using surfactants such as polyoxyethylene castor oil (Cremophor-EL), this type of surfactant has Sensitization, high incidence of allergic reactions after heavy use, see [Wei Xiaohui, et al. Chinese Journal of pharmaceuticals 2001, 32(4): 188-192]

Method used

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  • Aucklandia root oil containing emulsion, its preparation process and use
  • Aucklandia root oil containing emulsion, its preparation process and use
  • Aucklandia root oil containing emulsion, its preparation process and use

Examples

Experimental program
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Effect test

preparation example 1

[0028] Preparation example 1: preparation of woody oil

[0029] Take 1000g of dry woody powder, soak it with 60% ethanol at room temperature, reflux extract three times (3 × 5000ml), each extraction time is 2 hours, combine the filtrate, concentrate the filtrate under reduced pressure to a density of 1.20, add 5 times the volume of Diluted with water and extracted 3 times with ethyl acetate, combined the ester layer, concentrated under reduced pressure to recover the solvent, then put it on a silica gel column (200-300 mesh, 2000g), first washed 3 column volumes with petroleum ether, and continued to use petroleum ether-ethyl acetate Esters (20:1) were eluted for 4 column volumes, and the eluate was collected and the solvent was recovered under reduced pressure at 40°C to obtain 35 g of coyneolide, containing 32% of coynelide and 49% of dehydrocoynelide (w / w).

preparation example 2

[0030] Preparation example 2: preparation of woody oil

[0031]Take 500g of dry woody powder, soak it with 95% ethanol alcohol at room temperature, reflux extraction three times (3×3000ml), each extraction time is 2 hours, combine the filtrate, concentrate the filtrate under reduced pressure to a density of 1.20, add 5 times the volume Diluted with petroleum ether and extracted 3 times with petroleum ether, combined the ether layers, concentrated under reduced pressure to recover the solvent, and then put it on a silica gel column (200-300 mesh, 1000g), first washed 3 column volumes with petroleum ether, and continued to use petroleum ether-ethyl acetate Esters (20:1) were eluted for 4 column volumes, and the eluate was collected and the solvent was recovered under reduced pressure at 40°C to obtain 19 g of coyneolide, containing 38% of coynelide and 57% of dehydrocoynelide (w / w).

preparation example 3

[0032] Preparation example 3: preparation of woody oil emulsion

[0033] Take Preparation Example 2, 1 g of woody oil, 1.2 g of refined egg yolk phospholipid, and 0.04 g of oleic acid were added to 5.0 g of refined soybean oil, heated (50-90° C.), mixed until clear, and used as the oil phase. Disperse 2.25 g of glycerin into water for injection as the water phase. Under the condition of stirring, add the above-mentioned oil phase into the water phase dropwise to prepare a coarse emulsion, add water for injection to 100ml. The obtained coarse emulsion is further emulsified by a high-pressure homogenizer under the condition of a pressure of 100 MPa, and the pH value is adjusted to 5.0-9.0, and then sterilized after subpackaging to obtain a 10 mg / ml emulsion.

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Abstract

The invention discloses an oil emulsion containing banksia rose oil and its preparing process, wherein the emulsion comprises rich costunolide and dehydrogenated costuslactone. The invention also provides its use in preparing medicament for the treatment of endotoxemia caused by various reasons.

Description

technical field [0001] The invention relates to an emulsion containing woody oil and the preparation method and application of the emulsion. Background technique [0002] Muxiang is the dried root of Aucklandia lappa Decne., a perennial herb of Compositae. It is mainly produced in Yunnan, also known as Yunmuxiang. [0003] The ingredients in woody fragrance mainly include volatile oil, sterols, alkaloids, and organic acids. Pharmacological and pharmacodynamic studies in recent years have found that the main active ingredient of coriander is a mixture of various sesquiterpenoids based on costunolide and dehydrocostuslactone. It has obvious pharmacological effects in anti-inflammation, anti-tumor, anti-virus, inhibition of vasoconstriction and immune regulation. [0004] Chen et al. found that two compounds, corylidene and dehydrocorylidene, had the effect on human liver cancer cells Hep3B and HepA. 2 The gene expressions of hepatitis B surface antigen HBsAg and hepatitis B...

Claims

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Application Information

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IPC IPC(8): A61K36/289A61K9/107A61P9/00A61P29/00A61P31/12A61P35/00A61P37/02
Inventor 许卉王振华刘生生杨铁虹林东海
Owner SHANDONG LUYE PHARMA CO LTD
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