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Biological medical material with biological responding coating and preparing method

A biomedical material and responsive technology, applied in the direction of coating, can solve the problems of not promoting bone growth and bone resorption, dissolving and falling off particles of the coating, and high solubility of the coating, so as to achieve a simple and easy preparation method and low environmental pollution. , the effect of high phase purity

Inactive Publication Date: 2006-03-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydroxyapatite coating prepared by the plasma spraying method will appear impurity phases and the solubility of the coating itself is relatively large. During the application, the coating may dissolve and fall off and the formation of particles may occur, causing inflammation locally and activating osteoclasts. cell
Induces a series of cascade reactions leading to osteolysis, which eventually leads to implant failure problems
Moreover, neither hydroxyapatite nor bioactive ceramics such as tricalcium phosphate can promote bone growth or inhibit bone resorption, thus limiting its further application.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Dissolve calcium nitrate in ethanol to form an alcoholic solution with a concentration of 1 mol / L. Dissolve zinc nitrate in ethanol to form an alcoholic solution with a concentration of 0.005mol / L. Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OR) 3-X Phosphoric acid with a concentration of 1.0mol / L, and reflux for 24 hours, with hexafluorophosphoric acid as the fluorine-containing compound, with the molar ratio of Zn / Ca being 0.0001, Ca:P:F=1000:600:1 mixed, and the mixture was refluxed The sol obtained in 12 hours is coated on the surface of the medical substrate by dipping and pulling method.

Embodiment 2

[0022] Dissolve calcium acetate in ethanol to form an alcoholic solution with a concentration of 4 mol / L. Dissolve strontium nitrate in ethanol to form an alcoholic solution with a concentration of 0.1 mol / L. Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OR) 3-X Phosphoric acid with a concentration of 4.0mol / L, and reflux for 24 hours, with monofluorophosphoric acid as the fluorine-containing compound, with the molar ratio of Sr / Ca being 0.05, and the molar ratio of Ca:P:F being 5:3:1, mixing The sol obtained by refluxing the solution for 12 hours was coated on the surface of the medical substrate by the spin coating method.

Embodiment 3

[0024] Dissolve calcium nitrate in ethanol to form an alcoholic solution with a concentration of 2 mol / L. Dissolve manganese nitrate in ethanol to form an alcoholic solution with a concentration of 0.1 mol / L. Part of the OH group formed by dissolving phosphorus pentoxide in ethanol is replaced by an alcohol group, with a molecular formula such as PO(OH) X (OR) 3-X Phosphoric acid with a concentration of 2.0mol / L, and reflux for 24 hours, with ammonium fluoride as the fluorine-containing compound, with the molar ratio of Mn / Ca being 0.006, and the molar ratio of Ca:P:F being 15:9:1 and mixed, The sol obtained by refluxing the mixed solution for 24 hours is coated on the surface of the medical substrate by a solution spraying method.

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Abstract

The present invention discloses a biological medical material with biological resposibility coating layer and its preparation method. It is formed from medical basal body and metal-iron-doped fluorine-contained hydroxy apatite nano coating layer coated on the surface of medical basal body. Said biological medical material can stimulate osteoblast differentiation and proliferation in early stage of implatation, can promote growth of bone and can accelerate cure process. Said invention also provides the concrete steps of its preparation method.

Description

technical field [0001] The invention relates to a medical bio-coating material with a highly bio-responsive surface, especially a fluorine-containing hydroxyl group with metal ions doped with a surface that stimulates osteoblast differentiation and proliferation and promotes bone growth and is used for hard tissue replacement. Medical material of apatite nano-coating and preparation method thereof. Background technique [0002] Bioactive ceramics have attracted extensive attention due to their excellent osteoconductivity and biocompatibility, but as hard tissue bearing materials, single-phase ceramics or metals are difficult to meet the requirements of both mechanical properties and bioactive properties. At present, the method of coating the surface of the medical metal substrate with an active coating capable of forming an osseointegration with the hard tissue of the human body is mostly used. For example, Chinese patent CN1064610 adopts plasma spraying process to prepare ...

Claims

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Application Information

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IPC IPC(8): A61L27/32
Inventor 翁文剑苗顺东程逵宋晨路杜丕一沈鸽赵高凌张溪文徐刚汪建勋韩高荣
Owner ZHEJIANG UNIV
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