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Liquid medicine containing lucidril and preparing method

A liquid medicine and medicine technology, applied in the field of medicine, can solve the problems of high production cost, long preparation period of powder injection, high energy consumption, and achieve the effects of convenient taking, increasing the chance of drug contamination, and increasing operation procedures.

Inactive Publication Date: 2006-03-08
乔杰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For freeze-dried powder injections, the preparation cycle of powder injections is long, energy consumption is high, and production costs are high

Method used

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  • Liquid medicine containing lucidril and preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1: the liquid medicament containing chlorphenal

[0077] Prescription (according to 1000ml):

[0078] Meclofenoxate Hydrochloride 50g

[0079] Absolute ethanol 200ml

[0080] 1,2-Propanediol was added to make up to 1000ml.

[0081] Preparation:

[0082] Under the condition of meeting the GMP requirements for pharmaceutical manufacturing, take the prescribed amount of meclofenoxate hydrochloride, add 200ml of absolute ethanol, stir to dissolve, then add 1,2-propanediol to 1000ml, and stir evenly.

[0083] Filter with a 0.45 μm microporous membrane, take 500ml of the filtrate and fill it in ampoules, each with 5ml, fill with nitrogen, seal, and sterilize at 100°C for 15min to make an injection containing meclofenoxate hydrochloride.

[0084] After filtering with a 0.45 μm microporous membrane, the remaining filtrate is filled in a medicinal oral liquid glass bottle, 5 ml per bottle, filled with nitrogen, and sealed to make an ...

Embodiment 2

[0085] Embodiment 2: the liquid medicament containing chlorphenal

[0086] Prescription (according to 1000ml):

[0087] Meclofenoxate Hydrochloride 50g

[0088] Absolute ethanol 300ml

[0089] Add polyethylene glycol-300 to 1000ml.

[0090] Preparation:

[0091] Under the condition of meeting the GMP requirements for pharmaceutical manufacturing, take the aseptic, pyrogen-free meclofenoxate hydrochloride of the prescribed amount, add 300ml of absolute ethanol, stir to dissolve, then add polyethylene glycol to 1000ml, and stir evenly.

[0092] Filter and sterilize with a 0.22 μm microporous membrane, get 500ml of the filtrate and fill it in ampoules, each with 5ml, fill with nitrogen, and seal to make an injection containing meclofenoxate hydrochloride.

[0093] After filtering with a 0.22 μm microporous membrane, the remaining filtrate is filled in a medicinal oral liquid glass bottle, 5 ml per bottle, filled with nitrogen, and sealed to make ...

Embodiment 3

[0094] Embodiment 3: the liquid medicament that contains perchlorate

[0095]Prescription (according to 1000ml):

[0096] Meclofenoxate Hydrochloride 50g

[0097] Benzyl alcohol 10g

[0098] Absolute ethanol 400ml

[0099] Glycerin was added to 1000ml.

[0100] Preparation:

[0101] Under the condition of meeting the GMP requirements for pharmaceutical manufacturing, take the prescribed amount of meclofenoxate hydrochloride and benzyl alcohol, add 400ml of absolute ethanol, stir and dissolve, then add glycerin to 1000ml, and stir evenly.

[0102] Filter with a 0.45 μm microporous membrane, take 500ml of the filtrate and fill it in ampoules, each with 5ml, fill with nitrogen, seal, and sterilize at 100°C for 15min to make an injection containing meclofenoxate hydrochloride.

[0103] After filtering with a 0.45 μm microporous membrane, the remaining filtrate is filled in a medicinal oral liquid plastic bottle, 5 ml per bottle, fil...

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Abstract

The present invention provides a liquid medicine preparation containing meclofenoxate and its preparation method. Said liquid medicine preparation contains (a). meclofenoxate with pharmacological activity and effective dose for therapy and (b). alcoholic medicinal solvent formed from one or more than one alcoholic solvent.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicines, and relates to a liquid medicine, in particular to a liquid medicine containing cloproxenal, and a preparation method of the liquid medicine. 【Background technique】 [0002] Meclofenoxate (Meclofenoxate) was artificially synthesized in 1957 by Professor Thuillier of the French National Center for Scientific Research. Chlorester aldehyde can promote the oxidation-reduction metabolism of brain cells, increase the utilization of carbohydrates, and have an excitatory effect on patients with central nervous system depression. It is clinically used for traumatic coma, alcoholism, neonatal hypoxia, enuresis in children, etc. [0003] Due to the problem of the chemical stability of perchlorate aldehyde itself, the dosage forms used clinically are relatively limited. [0004] Taking oral dosage forms as an example, the 2005 edition of the "Chinese Pharmacopoeia" contains only capsules, and currently...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/221A61K9/08A61P25/32A61P43/00
Inventor 乔杰
Owner 乔杰
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