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Chinese medicinal composition with bilateral functions for treating angina pectoris and/or arrhythmia

A technology for arrhythmia and therapeutic effects, applied in the field of traditional Chinese medicine composition with bidirectional effects for treating angina pectoris and/or arrhythmia, and can solve the problems of no effective prevention and treatment methods for myocardial infarction and sudden death

Inactive Publication Date: 2006-02-15
GENERAL HOSPITAL OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Today, there are corresponding effective prevention and treatment measures for hypertension, hyperlipidemia, hypercoagulable state and AS, and the mortality rate is significantly reduced, but there is no effective prevention and treatment method for myocardial infarction and sudden death.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Example 1 Study on the anti-myocardial ischemia effect and mechanism of "Qihuaxin Yikang"

[0009] 1 Materials and Reagents

[0010] 1.1 Animals Healthy SD rats, weighing (226±28) g, both male and female, were purchased from the Experimental Animal Center of the PLA General Hospital. Rats in each group were under the same conditions, free to drink water, ingest food, and keep natural light.

[0011] 1.2 Drugs Panax notoginseng, breviscapus, and huixincao are all produced in Baoshan, Yunnan Province, and identified as Panax notoginseng, Herbaerigeronis, and Rhodobryum roseum Limp respectively by the Kunming Institute of Botany, Chinese Academy of Sciences. With water, 50% ethanol, 95% ethanol reflux extraction respectively, make extractum through rotary evaporation, then use distilled water to prepare the solution containing crude drug 0.225g / ml in high concentration and 0.056g / ml in low concentration as test sample liquid. Isoproterenol (Shanghai Hefeng Pharmaceutica...

Embodiment 2

[0028] Example 2 Study on the antiarrhythmic effect of "Qihuaxin Yikang"

[0029] 1.1 Animal health Kunming mice, weighing 34±4g, are half male and half male. Experimental Animal Center of PLA General Hospital. Rats in each group were under the same conditions, free to drink water, ingest food, and keep natural light.

[0030] 1.2 Medicines The source and identification of Panax notoginseng, Erigeron breviscapus, and Herba huixincao are the same as above. Extract with 95% ethanol and water under reflux, make corresponding extracts by rotary evaporation, and prepare solutions (3.25g crude drug / g mouse body weight) with distilled water respectively as the test drug solution. Verapamil Injection Propranolol Injection was produced by PLA General Hospital

[0031] 1.3 Instrument RM6240C multi-channel physiological signal acquisition and processing system, product of Chengdu Instrument Factory.

[0032] 2 Experimental methods

[0033] 2.1 Grouping and administration The mice (5...

Embodiment 3

[0039] Example 3 Study on the Hypoxia Resistance of "Qihuaxin Yikang"

[0040] 1 Materials and Reagents

[0041] 1.1 Animal health Kunming mice, weighing 18-22 g, were half male and half male. Experimental Animal Center of PLA General Hospital. Rats in each group were under the same conditions, free to drink water, ingest food, and keep natural light.

[0042] 1.2 Medicines The source and identification of Panax notoginseng, Erigeron breviscapus, and Herba huixincao are the same as above. Reflux extraction with 95%, 50% ethanol and water, make extract through rotary evaporation, each part is prepared into high concentration (13g crude drug / g mouse body weight) and low concentration (3.25g crude drug / g mouse body weight) with distilled water respectively ) solution as the test solution.

[0043] 2 Experimental methods

[0044]2.1 Grouping and Administration Mice (70 in total) were randomly divided into 7 groups, 10 in each group: control group, water phase low dose group, ...

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PUM

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Abstract

The invention relates to a traditional Chinese medicinal composition for treating angina pectoris and / or arrhythmia, wherein the preparation comprises notoginseng, Breviscapine and rush pith, and can be prepared into various dosage forms including tablet, capsule, granule, injection, and freeze-dried powder injection.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and mainly provides a traditional Chinese medicine composition composed of Panax notoginseng, Erigeron breviscapus and Herba huixincao, which has obvious anti-myocardial ischemia and arrhythmia effects; Extract, concentrate, and refine to obtain various active ingredients of medicines, that is, a composition composed of notoginseng saponins, flavonoid breviscapine, reflexa alkaloids, amino acids, stigmasterol, and the like. It specifically relates to their application in treating angina pectoris and arrhythmia symptoms caused by various reasons and their application in preparing anti-angina pectoris and / or arrhythmia products. technical background [0002] At present, domestic researches on anti-myocardial ischemia of traditional medicine are mostly focused on anti-hyperlipidemia and alleviating atherosclerosis. In fact, due to the progress of basic and clinical research, the morbidit...

Claims

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Application Information

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IPC IPC(8): A61K36/25A61K9/16A61K9/20A61K9/48A61K9/08A61K9/10A61P9/10A61P9/06
Inventor 刘屏王东晓汪进良王波戴畅王忠孝陈宜鸿周筱青
Owner GENERAL HOSPITAL OF PLA
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