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Method for preparing blood flow cutting off dispersing tablet

A technology for breaking blood flow and dispersible tablets, which is applied in the directions of blood diseases, medical raw materials derived from angiosperm subphylum, and pill delivery. , Easy to take, short disintegration time

Active Publication Date: 2006-01-04
苏州源创药物研究有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After a period of groping, the inventor finally explored the best process for preparing Duanxueliu dispersible tablets, and found no record of preparation of Duanxueliu dispersible tablets through the retrieval of professional journal literature

Method used

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  • Method for preparing blood flow cutting off dispersing tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] ① 3000 grams of traditional Chinese medicine cut blood flow, cut into sections, respectively add 12 and 10 times the amount of water to decoct twice for 1.5 hours each time, filter and combine the decoction; concentrate the filtrate to a relative density of 1.15 (80℃), add 1.7 Double the amount of ethanol, fully stir, let stand for 24 hours, take the supernatant, and concentrate to 250 grams of thick extract;

[0038] ②Add 500 grams of low-substituted hydroxypropyl cellulose to the thick extract, dry, pulverize, and pass through a 50-mesh sieve to make dry extract powder;

[0039] ③ 300 grams of cross-linked polyvinylpyrrolidone, crushed, passed through a 50-mesh sieve, mixed with the above dry extract powder, granulated with 95% ethanol, dried to prepare dry granules;

[0040] ④Add 7 grams of magnesium stearate and 3 grams of meringue to the dry granules, mix them evenly, and compress them into tablets to get ready.

[0041] formula:

[0042] Blood-broken thick extr...

Embodiment 2

[0049] ① 3000 grams of traditional Chinese medicine cut blood flow, cut into sections, respectively add 12 and 10 times the amount of water to decoct twice for 1.5 hours each time, filter and combine the decoction; concentrate the filtrate to a relative density of 1.15 (80℃), add 1.7 Double the amount of ethanol, fully stir, let stand for 24 hours, take the supernatant, and concentrate to 150 grams of thick extract;

[0050] ②Add 100 grams of low-substituted hydroxypropyl cellulose to the thick extract, dry, pulverize, and pass through a 50-mesh sieve to make dry extract powder;

[0051] ③50 grams of cross-linked polyvinylpyrrolidone, crushed, passed through a 50-mesh sieve, mixed with the above dry extract powder, granulated with 95% ethanol, dried to prepare dry granules;

[0052] ④ Add 3 grams of magnesium stearate and 7 grams of protein sugar to the dry granules, mix them evenly, and compress them into tablets to obtain.

[0053] formula:

[0054] Broken blood flow thick ...

Embodiment 3

[0061] It is an example of the preferred scheme of the preparation process.

[0062] ① 3000 grams of traditional Chinese medicine cut blood flow, cut into sections, respectively add 12 and 10 times the amount of water to decoct twice for 1.5 hours each time, filter and combine the decoction; concentrate the filtrate to a relative density of 1.15 (80℃), add 1.7 Double the amount of ethanol, stir well, let stand for 24 hours, take the supernatant and concentrate to 250 grams of thick extract;

[0063] ②Add 300 grams of low-substituted hydroxypropyl cellulose to the thick extract, dry, crush, and pass through a 50-mesh sieve to make dry extract powder;

[0064] ③200 grams of cross-linked polyvinylpyrrolidone, crushed, passed through a 50-mesh sieve, mixed with the above dry extract powder, granulated with 95% ethanol, dried to prepare dry granules;

[0065] ④Add 5 grams of magnesium stearate and 5 grams of meringue to the dry granules, mix them evenly, and compress them into tablets ...

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Abstract

The present invention relates to Chinese medicine technology, and is especially the preparation process of dispersive Chinese clinopodium herb tablet. The dispersive Chinese clinopodium herb tablet has the extract of Chinese clinopodium herb as active component and supplementary material. The dispersive Chinese clinopodium herb tablet is superior to available Chinese clinopodium herb capsule, tablet, oral liquid and other forms, and has the advantages of fast medicine releasing speed, corrected taste, easy carrying about and transportation.

Description

Technical field: [0001] The present invention relates to the technical field of traditional Chinese medicine, and is a preparation method for preparing a blood-broken dispersible tablet type by using the blood-broken extract of traditional Chinese medicine as the active ingredient and other auxiliary materials. Background technique: [0002] Broken blood flow has been included in the 2000 edition of the Chinese Pharmacopoeia. It is the dry aerial part of Clinopodium polycephalum (Vaniot) CYWu Hsuan or Clinopodium chinensis (Benth.) O. Kuntze of the Lamiaceae plant. . Nature and flavor and return channel: slightly bitter, astringent, cool; return to liver channel. Function cooling blood to stop bleeding. Traditional Chinese medicine is a commonly used hemostatic drug in clinical practice, which mainly treats bleeding caused by various reasons. The main function of the preparations made from Duanxueliu extract is to cool the blood to stop bleeding, and is more suitable for function...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/18A61K9/20A61P7/04
Inventor 于莉
Owner 苏州源创药物研究有限公司
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