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Effervescent Chinese medicine tablet for treating women's disease and its prepn process

A technology for gynecological diseases and effervescent tablets, which can be applied to medical formulas, medical preparations containing active ingredients, unknown raw materials, etc., and can solve problems such as slow dissolution, hindering popularization and application, and ineffectiveness of drugs

Inactive Publication Date: 2005-12-14
浙江南洋药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many kinds of drugs for the treatment of this kind of gynecological diseases, including traditional Chinese medicine compound preparations, western medicines, and dosage forms such as tablets, capsules, sprays, suppositories, lotions, etc. Folds, the general pharmaceutical preparations only reach the effective concentration in a small range after medication, it is difficult for the active ingredients to reach the folds where the pathogenic source is hidden, which leads to the inability of the drug to exert its maximum effect and reduces the curative effect
In addition, pharmaceutical preparations such as tablets, capsules, and suppositories, because they dissolve slowly and have a certain shape and hardness, increase discomfort when used in the vagina
However, sprays and lotions have greatly hindered their popularization and application because of the inconvenience of medication.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: In this example, 1000 effervescent tablets were prepared using 100g of the main ingredients Zizhuye, 10g of camphor, 100g of Bubu, 100g of Agrimony, 5g of Borneolum, 100g of Sophora flavescens, 10g of alum, 100g of Fructus Cnidii, and benzalkonium bromide. 6g and boric acid 60g, excipients include 70g sodium bicarbonate, 90g citric acid, 40g starch, 3g povidone, 60g hydroxypropyl cellulose, 5g magnesium stearate.

[0015] The above-mentioned pharmaceutical components are prepared according to the following steps:

[0016] (1) Grind Sophora flavescens and Fructus Cnidii into coarse powder, extract twice with 85% ethanol under reflux, each time for 1 hour, combine the extracts and filter, recover ethanol from the filtrate, condense into a thick paste, add the filtrate Concentrate, add appropriate amount of starch, stir evenly, and dry at 60°C for later use;

[0017] (2) Mix Zizhu Ye, Agrimony, Herbs and the medicinal residues extracted from step (1), add water...

Embodiment 2

[0021] Embodiment 2: Contain sodium bicarbonate 70g, citric acid 40g and tartaric acid 50g in the effervescent agent in the auxiliary material of this embodiment, filler adopts dextrin 40g, binding agent adopts ethyl cellulose 3g, disintegrant adopts cross-linked polymer Vinylpyrrolidone 60g, magnesium stearate 5g. The proportioning of principal agent is identical with embodiment 1.

[0022] Prepare 1000 effervescent tablets according to the preparation method described in Example 1.

Embodiment 3

[0023] Embodiment 3: The effervescent agent in the auxiliary material of this example contains 70g of potassium bicarbonate, 30g of fumaric acid and 60g of malic acid, 20g of lactose and 20g of microcrystalline cellulose as filler, and carboxymethyl cellulose as the binder 3 g of sodium, 20 g of cross-linked polyvinylpyrrolidone, 40 g of carboxymethylcellulose calcium, and 5 g of magnesium stearate were used as the disintegrant. The proportioning of principal agent is identical with embodiment 1.

[0024] Prepare 1000 effervescent tablets according to the preparation method described in Example 1.

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PUM

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Abstract

The present invention relates to medicine for treating women's diseases, and is especially one kind of effervescent Chinese medicine tablet for treating women's diseases and its preparation process. The effervescent Chinese medicine tablet is prepared with main components in 50-90 wt% and supplementary material in 10-50 wt% and through mixing and tabletting. The main components includes eight kinds of Chinese medicinal materials beautyberry leaf, camphor, sessile stemona root, agrimonia herb, borneol, etc. as well as benzalkonium bromide and boric acid. The effervescent Chinese medicine tablet has disintegrating time within 5 min, high leaching speed, less upset feeling and high use effect.

Description

technical field [0001] The invention relates to a dosage form of medicine for treating gynecological diseases, in particular to a traditional Chinese medicine effervescent tablet for treating gynecological diseases and a preparation method thereof. Background technique [0002] The incidence of gynecological diseases is high, and almost every woman will suffer from gynecological diseases in her lifetime, among which vaginitis has the highest incidence rate. At present, there are many kinds of drugs for the treatment of this kind of gynecological diseases, including traditional Chinese medicine compound preparations, western medicines, and dosage forms such as tablets, capsules, sprays, suppositories, lotions, etc. Folds, general pharmaceutical preparations only reach the effective concentration in a small range after administration, and it is difficult for the active ingredients to reach the folds where the pathogenic source is hidden, which leads t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
Inventor 马越峰谢元德杨建科朱旭雷
Owner 浙江南洋药业有限公司
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