Medicine composition for ophthalmology department
A composition and ophthalmic technology, applied in the direction of drug combination, boron compound active ingredient, heavy metal active ingredient, etc., can solve the problems of cyclodextrin deposition instability hidden danger, irritation and lack of stability, etc., to ensure chemical stability , easy to accept treatment, long-lasting effect
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Embodiment 1
[0023] The following ophthalmic pharmaceutical compositions were prepared in the following proportions.
[0024] Diclofenac Sodium 1.0g
[0025] Borax 3.0g
[0026] Boric acid 1.5g
[0027] Tromethamine 2.0g
[0029] Add water for injection to 1000.0ml
[0030] Preparation Process
[0031] Take about 50% of the prescribed amount of water for injection, dissolve diclofenac sodium, add borax, boric acid, tromethamine, and sodium chloride in turn after fully dissolved, heat to 100°C and boil for 15 minutes, cool down, and make up the full amount with water for injection.
Embodiment 2
[0033] prescription:
[0034] Diclofenac Sodium 0.5g
[0035] Borax 3.0g
[0036] Boric acid 1.5g
[0037] Sodium Hyaluronate 1.0g
[0038] Thimerosal 0.04g
[0039] Tromethamine 0.3g
[0040] Sodium chloride 6.3g
[0041] Add water for injection to 1000.0ml
[0042]Take the prescribed amount of sodium hyaluronate, add an appropriate amount of water for injection, and prepare a 0.1% solution, place it at 2-10°C for more than 12 hours, and set aside; take about 50% of the prescribed amount of water for injection, dissolve diclofenac sodium, and dissolve it completely Add borax, boric acid, tromethamine and sodium chloride in sequence, heat to 100°C and boil for 15 minutes, cool down to 35-40°C, add sodium hyaluronate solution, add thimerosal dissolved in advance, make up to full amount with water for injection, that is Obtain the composition of the present invention, its pH value is 8.2.
Embodiment 3
[0044] prescription:
[0045] Diclofenac Sodium 2.0g
[0046] Borax 11.5g
[0047] Boric acid 4.5g
[0048] Sodium Hyaluronate 0.2g
[0049] Thimerosal 0.04g
[0050] Tromethamine 1.2g
[0051] Sodium chloride 3.0g
[0052] Add water for injection to 1000.0ml
[0053] According to above-mentioned prescription, operate with the same method of embodiment 2, promptly obtain composition of the present invention, its pH value is 8.8.
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