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Dispersible tablet of acetazolamide and its preparation method

A technology of acetazolamide and dispersible tablets, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, organic active ingredients, etc., and can solve problems such as low bioavailability and poor control of intraocular pressure of drugs

Inactive Publication Date: 2005-12-07
马晶
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the cases where the application of acetazolamide failed, in addition to the cases where its use was limited due to its side effects, the rest were due to poor control of intraocular pressure due to poor absorption of the drug
Although acetazolamide sustained-release preparations are listed abroad, their bioavailability is lower, only 50% of that of immediate-release tablets

Method used

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Embodiment Construction

[0026] The present invention will be further described below in the form of embodiments, and the implementation details of the present invention will be given, but it is not intended to limit the protection scope of the present invention.

[0027] Acetazolamide, microcrystalline cellulose, sodium carboxymethyl starch, magnesium stearate, etc. were all passed through a 100-mesh sieve; 5 grams of polyvinylpyrrolidone and 1 gram of sodium lauryl sulfate were weighed to prepare a mixed aqueous solution for later use.

[0028] Weigh 250 grams of acetazolamide, first mix with 14 grams of sodium carboxymethyl starch in equal increments, then add 60 grams of microcrystalline cellulose to fully mix, and add the above mixed solution to make a soft material. Use a 30-mesh sieve to wet granulate, dry at 40°C, and then granulate with a 30-mesh sieve to make disintegrating granules with a particle size of less than 0.5mm. Then add 3 grams of magnesium stearate and mix well. After detecting...

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PUM

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Abstract

Disclosed is a dispersible tablet of acetazolamide where the preparation comprises, disintegrating acetazolamide, crystalline cellulose, sodium carboxymethylstarch, magnesium stearate, passing through 100 mesh sieve, charging polyvinylpyrrolidone, sodium dodecanesulphonate, mixing and disintegrating into particles, then charging magnesium stearate and mixing, adjusting sheet weight, tabletting so as to obtain the dispersible tablets. The dispersible tablets can be crumbled quickly, the crumbling time limit is less than 2 minutes, the other advantages include faster medicament dissolving and high biological availability.

Description

Technical field: [0001] The invention relates to a pharmaceutical composition containing acetazolamide, and relates to an improved technology of oral preparation of acetazolamide. technical background: [0002] Acetazolamide is a carbonic anhydrase inhibitor, which is mainly used to reduce intraocular pressure clinically, and can inhibit the activity of ciliary body epithelial carbonic anhydrase, thereby reducing the formation of aqueous humor (50% to 60%), and reducing intraocular pressure , suitable for the treatment of various types of glaucoma, has been playing an irreplaceable role in clinical practice. [0003] Acetazolamide is insoluble in water, and its bioavailability in ordinary tablets is low. In the cases where the application of acetazolamide failed, except for the cases where its use was limited due to its side effects, the rest were due to poor control of intraocular pressure due to poor absorption of the drug. Although acetazolamide sustained-release prepar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/433
Inventor 马晶
Owner 马晶
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