82 results about "Ciliary body" patented technology

Devices and methods for treating intraocular pressure are disclosed. The devices include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The shunts are preferably implanted by ab interno procedures.

A segmented scleral expansion band adapted for implantation within or fastening to a segment of the sclera of an eye lying outside of and adjacent to the ciliary body of the eye, is formed from a number of arcuate segments, curved to match the curvature of the globe of the eye, and joined together at each end to form a complete scleral expansion band. The band is implanted in the sclera of the eye by forming circumferential tunnels, inserting the band segments through the tunnels, and joining the ends of the segments to form a complete scleral expansion band. The scleral expansion band is useful in treating presbyopia and other ocular disorders.

Presbyopia is treated by implanting within a plurality of elongated pockets formed in the tissue of the sclera of the eye transverse to a meridian of the eye, a prosthesis having an elongated body having a first surface and a second surface opposite the first surface to contact the base and flap of the scleral pocket. The first and second surfaces are spaced apart a distance so that the implanted prosthesis exerts an outward force on the flap of the scleral pocket which results in an outward traction on at least the anterior margin of the scleral pocket. The combined effect of the implanted prostheses is to exert a radially outward traction on the sclera in the region overlying the ciliary body which expands the sclera in the affected region together with the underlying ciliary body. The expansion of the ciliary body restores the effective working distance of the ciliary muscle in the presbyopic eye and thereby increases the amplitude of accommodation. Hyperopia, primary open angle glaucoma and / or ocular hypertension can be treated by increasing the effective working distance of the ciliary muscle according to the invention. A preferred embodiment of the scleral prosthesis has a major surface adapted to contact the base or flap of the pocket and an opposite surface or ridge spaced from the major surface.

Presbyopia is treated by a method which uses ablative lasers to ablate the sclera tissue and increase the accommodation of the ciliary body. Tissue bleeding is prevented by an ablative laser having a wavelength of between 0.15 and 3.2 micron. A scanning system is proposed to perform various patterns on the sclera area of the cornea to treat presbyopia and to prevent other eye disorder such as glaucoma. Laser parameters are determined for accurate sclera expansion.

An intraocular lens (IOL) comprising an apparatus capable of changing power in response to ciliary body movement. An IOL is provided that comprises a first optical power element, and a second optical power element. The second optical power element is mechanically coupled to the first optical power element, and at least one of the first optical power element and the second optical power element is mechanically coupled to at least one magnet, such that a magnetic field applied to the at least one magnet causes the first optical element and the second optical element to displace relative to one another. The optical power elements may be surfaces or lens, the magnetic medium may be liquid, gel or solid.

A surgical method and apparatus for presbyopia correction removal of the sclera tissue are disclosed. Mechanisms based on sub-conjunctiva filled-in of the sclera area and cause the sclera-ciliary-body and zonule "complex" become more flexible (or less rigidity) are proposed. Total accommodation based a lens relaxation and lanes anterior shift is calculated and proposed as the guidance of the parameters for device design and clinical outcomes The preferred embodiments for the ablation patterns include radial lines, curved lines, ring dots or any non-specific shapes in a symmetric geometry. The surgery apparatus includes non-laser device of radio frequency wave, electrode device, bipolar device and plasma assisted device. Another preferred embodiment is to use post-operation medication such as pilocarpine (1%-10%) or medicines with similar nature which may cause ciliary body contraction for more stable and enhancement after the treatment.

This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

Presbyopia is treated by implanting within a plurality of elongated pockets formed in the tissue of the sclera of the eye transverse to a meridian of the eye, a prosthesis having an elongated base member having an inward surface adapted to be placed against the inward wall of the pocket and having a ridge on the inward surface of the base extending along at least a major portion of the major dimension of the base. The combined effect of the implanted prostheses is to exert a radially outward traction on the sclera in the region overlying the ciliary body which expands the sclera in the affected region together with the underlying ciliary body. The expansion of the ciliary body restores the effective working distance of the ciliary muscle in the presbyopic eye and thereby increases the amplitude of accommodation. Hyperopia, primary open angle glaucoma and / or ocular hypertension can be treated by increasing the effective working distance of the ciliary muscle according to the invention.

Systems and surgical techniques for presbyopia correction by laser removal of the sclera tissue are disclosed. The disclosed preferred embodiments of the system consists of a beam spot controller, a fiber delivery unit and a fiber tip. The basic laser including UV lasers and infrared lasers having wavelength ranges of (0.15-0.36) microns and (1.9-3.2) microns and diode lasers of about 0.98, 1.5 and 1.9 microns. Presbyopia is treated by a system which uses an ablative laser to ablate the sclera tissue outside the limbus to increase the accommodation of the ciliary body of the eye. The sclera tissue may be ablated by the laser with or without the conjunctiva layer open.

This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

Devices and methods for treating intraocular pressure are disclosed. The devices include drug delivery implants for treating ocular tissue. Optionally, the devices also include shunts for draining aqueous humor from the anterior chamber to the uveoscleral outflow pathway, including the supraciliary space and the suprachoroidal space. The drug delivery implants can be implanted in ab interno or ab externo procedures.

A cell culture system related to extended in vitro culture of mature retinal cells and methods for preparing the cell culture system are provided. Also provided is a retinal cell culture stress model related to extended in vitro culture of mature retinal cells in the presence of a stressor and methods for using the cell culture stress model. The invention provides a cell culture system comprising a long-term culture of mature retinal cells, without requiring addition of other types of non-retinal cells such as purified glia, or cells isolated from ciliary bodies within the eye, and the addition of a stressor such as light, A2E, cigarette smoke condensate, glutamate, or hydrostatic pressure. Methods for identifying bioactive agents that alter viability, neurodegeneration, or survival of retinal cells using the retinal cell culture stress system are also provided.

Delivery devices, systems and methods are provided for inserting an implant into an eye. The delivery or inserter devices or systems can be used to dispose or implant an ocular stent or implant, such as a shunt, in communication with the suprachoroidal space, uveal scleral outflow pathway, uveoscleral outflow path or supraciliary space of the eye. The implant can drain fluid from an anterior chamber of the eye to a physiologic outflow path of the eye, such as, the suprachoroidal space, uveal scleral outflow pathway, uveoscleral outflow path or supraciliary space. Alternatively, or in addition, the implant can elute a drug or therapeutic agent. The delivery or inserter devices or systems can be used in conjunction with other ocular surgery, for example, but not limited to, cataract surgery through a preformed corneal incision, or independently with the inserter configured to make a corneal incision. The implant can be preloaded with or within the inserter to advantageously provide a sterile package for use by the surgeon, doctor or operator.

A dynamic accommodative intraocular lens is provided in which a central lens portion of the intraocular lens undergoes dynamic change in curvature to adjust focus from distant objects to those nearby in response to natural accommodative actions of the patient's eye. The intraocular lens utilizes fluid movement from flexible fluid reservoirs defined along or adjacent haptic elements of the intraocular lens, which are engaged and compressed by the accommodating movements of the ciliary body of the patient's eye to cause expansion and flattening of the intraocular lens to adjust the optic power of the lens.

An accommodative lens assembly includes a lens body defining an optic lens, a haptic system, and a wing. The lens body is formed and implanted into an eye in a disaccommodative configuration. The haptic system includes one or more haptics that support the optic lens and transmits forces from an anatomical structure such as a ciliary body of the eye, causing the optic lens to deform into an accommodative configuration. In order to stabilize the optic lens so that the optic lens is not displaced from its implantation site, the wing anchors the optic lens within an anterior capsulorhexis of the capsular bag such that the transmitted forces that deform the optic lens during accommodation do not also displace the optic lens from its implanted position. When implanted, the optic lens is anterior to the capsular bag.

The invention comprises a device for treating presbyopia. A stretch segment is provided for intraocular implantation into the annular sulcus region defined by the intersection of the iris and ciliary body. The stretch segment engages and exerts an outward radial tension against the ciliary body. The segment is designed to take up slack in the equatorial zonules in the presbyopic eye, such that their effective working distance is enhanced. This aids in the accommodation process which affects the curvature of the lens for near viewing. The segment may a closed ring, or may be open ended.

A presbyopia correcting intraocular lens implant for implanting in a human eye includes an implant body having a central lens enclosure and at least one stability tab extending therefrom. At least one ciliary body sensor senses movement of the eye's ciliary body. An electronic module is embedded in the implant body and includes a microprocessor communicative with the ciliary body sensor. A dynamic lens assembly is housed in the central lens enclosure and has a dynamic range of continuous accommodation. The lens implant also includes a renewable intraocular power supply.

Presbyopia is treated by a method which uses ablative lasers to ablate the sclera tissue and increase the accommodation of the ciliary body. Tissue bleeding is prevented by an ablative laser having a wavelength of between 0.15 and 3.2 micron. A scanning system is proposed to perform various patterns on the sclera area of the cornea to treat presbyopia and to prevent other eye disorder such as glaucoma. Laser parameters are determined for accurate sclera expansion.REEXAMINATION RESULTSThe questions raised in reexamination request no. 90 / 006,090, filed Aug. 22, 2001, have been considered and the results thereof are reflected in this reissue patent which constitutes the reexamination certificate required by 35 U.S.C. 307 as provided in 37 CFR 1.570(e), for ex parte reexaminations, or the reexamination certificate required by 35 U.S.C. 316 as provided in 37 CFR 1.997(e) for inter partes reexaminations.

This invention relates to intraocular lenses. More particularly, this invention relates to intraocular lenses that have the ability to alter the light refractive power in response to changes in the tension of the ciliary muscle or ciliary body of the eye or any other accommodative forces. Lenses of this invention are generally referred to as interfacial, i.e., lens properties being defined as the interface of two liquids having different refractive indices, refractive accommodating lenses (IRAL).

The present invention relates, generally, to improved methods of delivering a biologically active agent, in particular a therapeutic or prophylactic nucleic acid, to the ocular sphere of a subject comprising administering said agent to the ciliary body tissue(s) or cells and / or to the extra-ocular muscle tissue or cells. More particularly, the invention relates to devices, their uses, notably in gene therapy, and to methods for treating pathologies of the ocular sphere by specific ciliary body tissue(s) or cells and / or extra-ocular muscle or cells administration of a therapeutic product and transfer thereof into the ocular tissue to be treated. This invention also relates to pharmaceutical compositions comprising the product in a form suitable for ciliary body tissue(s) or cells and / or extra-ocular muscle or cells administration, their preparation and uses.

A method and surgical technique for corneal reshaping and for presbyopia correction are provided. The preferred embodiments of the system consists of a scanner, a beam spot controller and coupling fibers and the basic laser having a wavelength of (190-310) nm, (0.5-3.2) microns and (5.6-6.2) microns and a pulse duration of about (10-150) nanoseconds, (10-500) microseconds and true continuous wave. New mid-infrared gas lasers are provided for the corneal reshaping procedures. Presbyopia is treated by a method which uses ablative laser to ablate the sclera tissue and increase the accommodation of the ciliary body. The tissue bleeding is prevented by a dual-beam system having ablative and coagulation lasers. The preferred embodiments include short pulse ablative lasers (pulse duration less than 200 microseconds) with wavelength range of (0.15-3.2) microns and the long pulse (longer than 200 microseconds) coagulative lasers at (0.5-10.6) microns. Compact diode lasers of (980-2100) nm and diode-pumped solid state laser at about 2.9 microns for radial ablation patterns on the sclera ciliary body of a cornea are also disclosed for presbyopia correction using the mechanism of sclera expansion.