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Chinese medicine preparation for treating rheumatism and preparation and use

A traditional Chinese medicine preparation, rheumatism technology, applied in the directions of non-central analgesics, antipyretics, anti-inflammatory agents, etc., can solve the problems of non-specific immunosuppression of the body, no effective treatment method, incomplete pathogenesis, etc. Less toxic and side effects, avoiding toxic effects, and significant curative effect

Inactive Publication Date: 2005-10-19
湖北中医学院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because its pathogenesis is not completely clear, there is no specific treatment at present (Lu Junjian, Chinese and Western Medicine Diagnosis and Treatment of Connective Tissue Diseases, People's Health Publishing House, 1992: 348)
Comprehensive treatment such as corticosteroid hormones and cytotoxic drugs is often used clinically, but this often leads to adverse consequences such as non-specific immunosuppression of the body

Method used

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  • Chinese medicine preparation for treating rheumatism and preparation and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] API W 3 preparation of

[0019] See attached figure 1

[0020] Take Diwu coarse powder, add 8 to 12 times of water to reflux and extract 3 to 4 times, each time for 1 to 3 hours, combine the extracts, concentrate the extracts under reduced pressure to dryness, add 50% to 80% ethanol, filter out the precipitate, The alcohol extract was obtained, concentrated to dryness under reduced pressure, dissolved in water, filtered, adsorbed on D101 macroporous resin on the filtrate, and eluted with water, 40%-80% ethanol, 80%-95% ethanol in sequence; collected 40%-80% Ethanol eluate, recovered ethanol and evaporated to dryness in a water bath to obtain diguanoside; dry column chromatography on silica gel for the obtained diguanoside, and eluted with a mixture of chloroform:methanol:water=20:10:1 volume ratio , roughly divided into 5 sections, high performance liquid chromatography (TLC) detection, collecting the second section part rich in diguanin W3, and then going to silica ...

Embodiment 2

[0022] Rat long-term toxicity test:

[0023] To investigate the long-term toxicity of Diwu extract 864, 288, 96mg / kg doses of continuous intragastric administration for 6 months. Observe the general condition of the animals, body weight changes, hematology, blood biochemistry, general anatomy of organs, organ coefficients and histopathological changes. Results None of the animals died. There was no statistical difference in the general situation of the animal test of each dose group at the end of the 3-month test period and the recovery period, body weight change, hematology, blood biochemistry, general anatomy of the whole body organs, and organ coefficients compared with the negative control group. At the end of the test, the histopathological examination of each dose group indicated that the proportion of hyperplastic lobules in the thyroid follicular lobules was different, among which the hyperplastic lobules accounted for more than 50% of the thyroid follicular lobules i...

Embodiment 3

[0025] Beagle dog long-term toxicity test:

[0026] Investigate the long-term toxicity of the extract of Diwu 128mg / kg, 256mg / kg and 512mg / kg for 9 months. Observe the general condition of the animals, body weight change, fecal and urine routine, electrocardiogram, hematology, blood biochemistry, general anatomy of the whole body organs, organ coefficient and histopathological changes. As a result, none of the animals died. There was no statistical difference in the indicators of the high, medium and low dose groups in the animal test for 3 months, 6 months, 9 months and the recovery period compared with the blank control group. The long-term toxicity test results show that it is safe to feed and administer Diwu extract to Beagle dogs at 128mg / kg, 256mg / kg and 512mg / kg for 9 consecutive months.

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Abstract

The Chinese medicine preparation, Fengshi'an, for treating rheumatism has the effective component 3-O-alpha-L-pyranorhamnose (1->2)-beta-D-xylopyranose-oleanolic acid-28-O-alpha-L-pyranorhamnose(1->4) beta-D-pyranoglucose (1->6) beta-D-glucopyranoside, named flaccid anemone saponin W3, and with molecular expression of C59H96O25. Flaccid anemone saponin W3 is prepared with coarse flaccid anemone rhizome powder, and through reflux extraction, concentration, adsorption and elution in macroposrous resin, adsorption and elution in dry silicon gel column and liquid separation. Flaccid anemone saponin W3 is further prepared into Chinese medicine preparation with flaccid anemone saponin W3 content over 90 wt%, and the Chinese medicine preparation is used in treating rheumatic diseases with high curative effect and less toxic side effect.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation for rheumatic diseases and its preparation and application. Background technique [0002] Rheumatic diseases are common autoimmune diseases that can affect multiple organs and tissues. Clinical morbidity is high. Because its pathogenesis is not completely clear, there is no specific treatment at present (Lu Junjian, Chinese and Western Medicine Diagnosis and Treatment of Connective Tissue Diseases, People's Medical Publishing House, 1992: 348). Clinically, comprehensive treatment such as corticosteroid hormones and cytotoxic drugs is often used, but this often causes adverse consequences such as non-specific immunosuppression of the body. [0003] The dried rhizome of Anemone flaccida Fr. Schmidt, a plant of the genus Anemone (Anemone flaccida Fr. Schmidt) in the Ranunculaceae family. It is recorded in "Guizhou Folk Medicine" and "Zhejiang Tianmu Mountain Drug Chronicle" that it is ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61P19/02A61P29/00
Inventor 邴飞虹
Owner 湖北中医学院
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