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Gel agent for treating glaucoma and its preparing process

A gel and glaucoma technology, applied in the field of medicine, can solve the problems of high price, reduce the possibility of absorption, increase the residence time, and improve the adaptability

Inactive Publication Date: 2005-07-06
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It belongs to the in-situ gel, which belongs to a relatively special gel, but due to the particularity of the materials used, its price is relatively high

Method used

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  • Gel agent for treating glaucoma and its preparing process
  • Gel agent for treating glaucoma and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Raw material parts by weight

[0018] Timolol maleate 0.6830

[0019] Hydroxypropyl Methyl Cellulose 1.5

[0020] Ethylparaben 0.03

[0021] Edetate disodium (EDTA-2Na) 0.03

[0022] Sodium sulfite 0.2

[0023] Glycerin 2

[0024] Add distilled water to 100.

[0025] Preparation:

[0026] A Dissolve hydroxypropyl methylcellulose in water first, which is called a solution.

[0027] B Dissolve the prescribed amount of ethyl paraben with hot water, the temperature of the hot water is 80 or 85 or 88 or 90 or 92 or 95 ° C, called b solution.

[0028] C Add solution b, timolol maleate, disodium edetate (EDTA-2Na), sodium sulfite, and glycerin to solution a according to the above ratio, and add 100 parts of distilled water. Timolol maleate gel can be made. The drug content in the gel is 0.5%.

Embodiment 2

[0030] Raw material parts by weight

[0031] Timolol maleate 0.3415

[0032] Hydroxypropyl Methyl Cellulose 1.0

[0033] Ethylparaben 0.03

[0034] Edetate disodium (EDTA-2Na) 0.03

[0035] Sodium bisulfite 0.2

[0036] Glycerin 2

[0037] Add distilled water to 100.

[0038] The preparation steps are the same as in Example 1. The drug content in the gel is 0.25%.

Embodiment 3

[0040] Raw material parts by weight

[0041] Timolol maleate 0.6830

[0042] Methylcellulose 1.0

[0043] Ethylparaben 0.03

[0044] Edetate disodium (EDTA-2Na) 0.03

[0045] Sodium bisulfite 0.2

[0046] Glycerin 2

[0047] Add distilled water to 100.

[0048] The preparation steps are the same as in Example 1. The drug content in the gel is 0.5%

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PUM

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Abstract

The invention discloses a gel agent for treating glaucoma and its preparing process which comprises Timolol Maleate, macromolecular material, glycerin, Ethylparabenum, Disodium Edetate, anti-oxidant agent, and distilled water, the preparation consists of steeping the macromolecular material into water, dissolving the Ethylparabenum with hot-water, charging Ethylparabenum solution, Timolol Maleate, glycerin, anti-oxidant agent, Disodium Edetate into macromolecular solution, agitating homogeneously.

Description

technical field [0001] The invention relates to the technical field of medicine, more specifically to a gel for treating glaucoma, and also to a preparation method of the gel, which can be used for treating glaucoma. Background technique [0002] Timolol maleate is a non-selective β-receptor blocker. It has been widely used in open-angle and angle-closure glaucoma in recent years because it has a good effect on lowering intraocular pressure and has few side effects. As well as the clinical treatment of secondary glaucoma and other ocular hypertension, and is considered to be the most ideal drug for the treatment of open-angle glaucoma. The traditional dosage form of open-angle glaucoma drugs is eye drops, but there are disadvantages of low drug bioavailability and repeated administration, and the absorption of the nasolacrimal duct may cause side effects on the cardiovascular and respiratory systems. Merck Company launched Timoptic XE, a long-actin...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/5377A61P27/06
Inventor 郑穹彭俊清段建利
Owner WUHAN UNIV
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