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Percutaneous contraceptive drugs delivery system and method

A contraceptive, system technology, applied in the directions of pharmaceutical formulation, sheet delivery, drug combination, etc., can solve the problem of unsatisfactory skin penetration rate, and achieve the effect of reducing skin penetration time, less side effects, and improving skin penetration rate

Active Publication Date: 2005-07-06
RUNBIO BIOTECH CO LTD
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0011] However, the release rate of the existing transdermal technology is still unsatisfactory for the release rate of contraceptives, especially the transdermal rate of levonorgestrel. Transdermal rate to the blood, in order to achieve the purpose of contraception more safely and effectively

Method used

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  • Percutaneous contraceptive drugs delivery system and method
  • Percutaneous contraceptive drugs delivery system and method
  • Percutaneous contraceptive drugs delivery system and method

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Embodiment

[0072] components

[0073] Other embodiments adjust the consumption of each of the above-mentioned components within the scope of the present invention, and the resulting product is still effective.

[0074] Production process:

[0075] The TCDS patch with the above formula is made according to the following steps: Weigh the steroid hormone and the moisturizing agent in turn, and put them into a glass bottle. The skin penetration enhancer composition given in Table 1 was added and the glass bottle was shaken until the hormone and PVP / VA copolymer were dissolved. The glass vial was sealed after addition of the polypropionate viscous polymer solution. The contents of the vial were stirred with a magnetic stir bar at about 200 rpm for 6 hours at room temperature to form a homogeneous solution. The glass jars were left overnight until all air bubbles had disappeared.

[0076] The resulting solution was coated onto a sheet of backing layer to a thickness of 600 micron...

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Abstract

The invention provides a percutaneous contraceptive drugs delivery system and method, wherein the delivery system (TCDS) comprises a back lining layer, a viscous polymeric medicine storage layer adhered on the back lining layer, a strippable protective layer adhered on the viscous polymeric medicine storage layer, the viscous polymeric medicine storage layer comprises skin permeable accelerant composition, humectant, viscous polymer, active dosage of one or more steroid hormones, wherein the skin permeable accelerant composition is a mixture of dimethyl sulphoxide, 2-hydroxypropanoic aliphatic alcohol ester, diethylene glycol alkyl ether and oleinic acid by the initial weight ratio of 2 : 1 : 1 : 0.8 to 5 : 1 : 1 : 0.8. The invention can substantially improve steroid hormone transdermal speed and increase TCDS effectiveness and convenience.

Description

technical field [0001] The invention relates to a transdermal contraceptive delivery system and method. Background technique [0002] Combinations of natural or synthetic estrogen and synthetic progesterone used to be used in doses for contraceptive purposes, if the natural estrogen (17-beta estradiol) and progesterone were taken orally (Progesterone) combination, these two hormones will need to be used in very large doses due to a large amount of primary metabolism in the liver, which often causes undesired side effects. Although the composition of synthetic progesterone and estrogen is mainly used as oral contraceptives to overcome these defects now. But the use of this type of oral contraceptives still has certain side effects. [0003] Higher rates of blood clots and associated vascular conditions including stroke, myocardial infarction among women using this oral contraceptive; complications of use of this pill also include cancer of the bre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K31/56A61K45/00A61M37/00A61P15/18
Inventor 郑会义杨明京
Owner RUNBIO BIOTECH CO LTD
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