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External preparation with analgesic and anti-inflammatory effects and preparation method thereof

A technology of external preparations and moisturizing agents, applied in the field of biomedicine, can solve the problems of low bioavailability of drugs, unsatisfactory drug penetration effects, etc., and achieve the effects of improving analgesic and anti-inflammatory therapeutic effects, increasing skin penetration rate, and convenient use

Inactive Publication Date: 2020-03-27
武汉市蔡氏福宁中草药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the symptomatic treatment for pain caused by sprains, strains, strains and osteoarthritis is mainly treated by smearing or oral medicine, but the penetration effect of the treatment medicine by smearing is not ideal. Utilization is very low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] An external preparation with analgesic and anti-inflammatory effects, comprising a pharmaceutical composition and a hydrogel matrix; wherein,

[0031] The pharmaceutical composition is: Chuanxiong oil 80g and ibuprofen 5g;

[0032] The hydrogel matrix is: polyacrylamide 10g, sodium alginate 15g, ethanol 80g, glycerin 100g, paraben 10ml, distilled water 785g.

[0033] The preparation method of the external preparation comprises the following preparation steps:

[0034] (1) Evenly disperse acrylamide and sodium alginate into distilled water, then add ethanol, glycerin and parabens to stir evenly, add NaOH after stirring evenly, and stir while adding, adjust the pH to 6.8, and complete the hydrogel Matrix preparation;

[0035] (2) Dissolve ibuprofen and Chuanxiong oil in 300g of absolute ethanol, then slowly drop into 20ml of polyethylene glycol 200, place in a mortar and grind thoroughly;

[0036] (3) Add the pharmaceutical composition prepared in step (2) into the hyd...

Embodiment 2

[0038] An external preparation with analgesic and anti-inflammatory effects, comprising a pharmaceutical composition and a hydrogel matrix; wherein,

[0039] The pharmaceutical composition is: Chuanxiong oil 83g and ibuprofen 6g;

[0040] The hydrogel matrix is: 13g of polyacrylamide, 16g of sodium alginate, 84g of ethanol, 110g of glycerin, 12ml of parabens, and 765g of distilled water.

[0041] The preparation method of the external preparation comprises the following preparation steps:

[0042] (1) Evenly disperse acrylamide and sodium alginate into distilled water, then add ethanol, glycerin and parabens to stir evenly, after stirring evenly, add NaOH, stir while adding, adjust the pH to 7.2, and complete the hydrogel Matrix preparation;

[0043] (2) Dissolving ibuprofen and Ligusticum chuanxiong oil in 300g of absolute ethanol, then slowly drop into 10ml of polyethylene glycol 200, place in a mortar and grind thoroughly;

[0044] (3) Add the pharmaceutical composition ...

Embodiment 3

[0046] An external preparation with analgesic and anti-inflammatory effects, comprising a pharmaceutical composition and a hydrogel matrix; wherein,

[0047] The pharmaceutical composition is: Chuanxiong oil 88g and ibuprofen 8g;

[0048] The hydrogel matrix is: polyacrylamide 12g, sodium alginate 16g, propylene glycol 85g, glycerin 130g, chlorocresol 12ml, distilled water 745g.

[0049] The preparation method of the external preparation comprises the following preparation steps:

[0050] (1) Evenly disperse acrylamide and sodium alginate in distilled water, then add propylene glycol, glycerin and chlorocresol to stir evenly, add NaOH after stirring evenly, adjust the pH to 7.5 while adding, and complete the hydrogel matrix preparation;

[0051] (2) Dissolving ibuprofen and Ligusticum chuanxiong oil in 300g of absolute ethanol, then slowly drop into 10ml of polyethylene glycol 200, place in a mortar and grind thoroughly;

[0052] (3) Add the pharmaceutical composition prepa...

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Abstract

The invention discloses an external preparation with analgesic and anti-inflammatory effects. The external preparation comprises a drug composition and a hydrogel matrix; the drug composition consistsof 80-100g of Sichuan lovage rhizome oil and 5-10g of ibuprofen; and 1000g of the hydrogel matrix consists of the following components in percentage by weight: 10-15g of polyacrylamide, 15-20g of sodium alginate, 80-100g of a transdermal absorption enhancer, 100-150g of a humectant, 10-15ml of a preservative and the balance of distilled water. According to the external preparation with the analgesic and anti-inflammatory effects, the hydrogel matrix is used as a carrier to be added with the drug composition, so that a drug loading amount of the hydrogel matrix is increased, the transdermal rate of drugs can be improved, and the drugs are transferred in a transdermal drug delivery mode. In addition, the external preparation is convenient to use, the action effect of the drug is improved toa great extent, and meanwhile, the analgesic and anti-inflammatory treatment effect can be obviously improved.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an external preparation with analgesic and anti-inflammatory effects and a preparation method thereof. Background technique [0002] Transdermal drug delivery refers to the application or application of drugs on the surface of the skin, so that the drugs can pass through the skin (stratum corneum, epidermis, and dermis), reach the subcutaneous tissue, and finally reach the lesion through internal circulation to achieve the effect of drug treatment. . With the continuous development of biotechnology, a large number of new drugs are constantly emerging, and the traditional drug delivery methods (such as oral or injection) will cause the efficacy of some biosynthetic drugs based on DNA or protein to be affected. The pain of injection administration will bring psychological discomfort to some people, while oral administration has problems such as fluctuations in bloo...

Claims

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Application Information

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IPC IPC(8): A61K36/236A61K9/06A61K47/36A61P29/00A61K31/192
CPCA61K9/0014A61K9/06A61K31/192A61K36/236A61K47/36A61P29/00A61K2300/00
Inventor 蔡剑军
Owner 武汉市蔡氏福宁中草药有限公司
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