Composition containing high content conjugated linoleic acid and its preparation method

A technology of conjugated linoleic acid and its composition, which is applied in the field of biomedicine, can solve the problems of low CLA content and poor effect, and achieve the effects of reducing blood fat, reducing body fat, and increasing muscle

Inactive Publication Date: 2005-03-23
THE FIRST INST OF OCEANOGRAPHY SOA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have shown that the higher the content of CLA, the better the effect; the lower the content of CLA, the poorer the effect; the different ratio of the two main isomers, the greater the difference in effect

Method used

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  • Composition containing high content conjugated linoleic acid and its preparation method
  • Composition containing high content conjugated linoleic acid and its preparation method
  • Composition containing high content conjugated linoleic acid and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1: the preparation of high-content CLA composition,

[0047] Take 50g of CLA composition with a total CLA content of about 81%, carefully inject it into the top of the prepared φ5×50cm silica gel chromatography column at room temperature, open the valve at the lower end of the chromatography column, and control the flow rate to 5ml per minute. After it completely entered the column bed, it was eluted with n-hexane. Every 100ml of eluate was collected in a round bottom flask, after every 100ml was collected, the samples were mixed and directly injected into gas chromatograph to measure its fatty acid composition. The instrument used is a GC-14C gas chromatograph: its chromatographic column is a 0.25mm×100M, CP-SL 88 capillary column, and the detector is a hydrogen flame ionization detector; the analysis conditions are: injector temperature 250°C, The detector temperature is 260°C, and the column temperature is 230°C.

[0048] According to the measurement res...

Embodiment 2

[0054] Example 2: Effects of compositions with different CLA contents on body weight of obese mice,

[0055] 40 obese mice were randomly divided into 4 groups, wherein the three groups were given the same dose of CLA compositions containing 90% and 80% fatty acid type and 80% ethyl fat type (respectively marked as CLA-90, CLA-80 and CLA-80EE), the other group is the control, continuous 36 days, see the results figure 1 . The body weight of mice ingested CLA-90 was lower than that of other groups, and there were significant differences (P<0.05).

Embodiment 3

[0056] Example 3: Effects of compositions with different CLA contents on blood sugar in diabetic mice,

[0057] Four groups of mice suffering from diabetes were given equal amounts of CLA-90, CLA-80 and CLA-80EE compositions respectively, and their effects on blood sugar concentration are shown in figure 2 . All the CLA compositions in the three groups can lower the blood sugar of the mice. But CLA-90 had the best effect, which was significantly different from CLA-80 and CLA-80EE (P<0.05).

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Abstract

A high-content conjugated linoleic acid (CLA) composition in the form of oily liquid or powder for preventing and treating obesity, diabetes and hyperlipemia is disclosed, which features high content of CLA (90-95%). It can be used also as health-care food.

Description

technical field [0001] The invention relates to the improvement of fatty acid technology, specifically a composition with high content of conjugated linoleic acid and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] Conjugated linoleic acid (English name: Conjugated linoleic acid, abbreviated as CLA) has many important physiological functions such as lowering blood sugar, blood fat, body fat, increasing muscle, improving immunity, and anti-cancer. There is a US patent 6,015,833 which disclosed a conjugated linoleic acid composition (Conjugated linoleic acid compositions). This patent discloses c9, t11-CLA and t10, c12-CLA two main isomers and other isomers in the CLA composition, but there is no disclosure of the content and composition ratio of these two main isomers, The application effect of this CLA is also not disclosed. Another U.S. patent (publication number is 20010025113) discloses another composition of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K9/16A61K9/20A61K9/48A61K9/50A61K31/202A61P3/04A61P3/06A61P3/10
Inventor 刘发义李光友姜伟石红旗
Owner THE FIRST INST OF OCEANOGRAPHY SOA
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