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Method for preparing freeze dried powder injection of rhodiola root

A technology of Rhodiola rosea and powder injection, which is applied in the preferred field of scaffold in powder injection, and can solve the problems of product appearance shrinkage, agglomeration, unsatisfactory stability, etc.

Inactive Publication Date: 2005-03-16
SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

The rapid onset of intravenous injection is of great significance for saving patients with coronary heart disease, but the long-term storage stability of Rhodiola injection is still not ideal, which affects its clinical use. One way to overcome this deficiency
And at present, in the preparation of freeze-dried powder injections of traditional Chinese medicine, there are often problems such as high water content, product appearance shrinkage or agglomeration, and poor resolubility. Appropriate scaffolding agent and its dosage are crucial for forming qualified powder injection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] Example: Rhodiola rosea 1000g, add 50% ethanol to reflux extraction 3 times, each time for 1 hour, combine the extracts, recover under reduced pressure to obtain a liquid extract with a specific gravity of 1.0-1.1.

[0026] Add 5% gelatin aqueous solution to the liquid extract, stir well until no precipitation occurs, place at a low temperature of 5°C for 12-24 hours, centrifuge, filter, recover the solvent under reduced pressure, add 95% ethanol until the alcohol concentration reaches 80%, and adjust the pH to 8.0 , placed at 5°C for 12-24 hours, filtered, and the filtrate was decompressed to recover ethanol to obtain a fluid extract with a specific gravity of 1.2-1.4.

[0027] Rhodiola rosea extract 1000g prepared above, add 800g mannitol, add water for injection to 4000 milliliters, heat for dissolving, add gac to depyrogenate, remove charcoal, filter through 0.15-0.22um filter membrane, ultrafiltration membrane block (molecular weight cut-off greater than 1000) into...

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PUM

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Abstract

The invention relates to a rhodiola root powder and injection preparation and its preparing method, wherein the active component of the medicament is salidroside, the preferred supporting agent is one of mannitol, dextran, glucose, sorbitol, lactose, gelatin, disodium hydrogen phosphate - sodium dihydrogen phosphate, calcium lactobionate, dextran- glucose.The ratio of the rhodiola root extract and the supporting agent is 1 : 0.2-1.2.

Description

technical field [0001] The invention relates to a preparation method of Rhodiola rosea freeze-dried powder injection for treating coronary heart disease, and particularly relates to the optimization of support agent in the powder injection. Background technique [0002] Rhodiola is Rhodiola sachalinesis A.Bor. or R.kirilowlii(Regel)Regel[Sedum kirilowii Regel], Rhodiola sacra(Prainex Hamet) Fu, Rhodiola grandiflora R. crenulata or the dry whole plant of the same genus. As early as in the folks, it was used for clearing the lungs and relieving coughs, stopping bleeding, and stopping belts, or for external use to treat bruises, burns, etc. Jingzhu Materia Medica contains: "It tastes sweet, astringent, and smells fragrant. It is effective in treating plague and epidemic diseases, lung diseases, and loose swelling." Modern studies have shown that the drug has obvious heart protection and anti-hypoxia effects. It is clinically used for anti-hypoxia and anti-hypoxia. Treatment o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7028A61P9/10
Inventor 王健
Owner SHANDONG LUOXIN PARMACEUTICAL GROUP STOCK CO LTD
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