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Domperidone drop pill and preparing method thereof

A technology of perperidone dropping pills and domperidone, which is applied in the directions of pill delivery, digestive system, drug combination, etc., can solve the problems of long disintegration time of domperidone tablets, affecting the therapeutic effect of domperidone, low dissolution rate and dissolution rate, etc. and ease of administration, small pill size, and improved dissolution and dissolution rate

Inactive Publication Date: 2004-09-15
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Domperidone tablets have long disintegration time, low dissolution rate and dissolution rate, poor absorption, low bioavailability, large proportion of excipients, children, elderly, bedridden patients and patients with dysphagia are inconvenient to take and poor compliance, which affects the therapeutic effect of domperidone play

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0053] prescription:

[0054] Domperidone 5g

[0055] Macrogol 6000 15g

[0056] Makes 1000 capsules

[0057] Preparation method: Take the fine powder of domperidone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten polyethylene glycol 6000 matrix, stir well, use simethicone as a coolant, make pellets by drop method, and dry to obtain.

example 2

[0059] prescription:

[0060] Domperidone 5g

[0061] Macrogol 4000 15g

[0062] Makes 1000 capsules

[0063] Preparation method: Take domperidone fine powder that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to molten polyethylene glycol 4000 matrix, stir well, use simethicone as coolant, make pellets by drop method, and dry to obtain.

example 3

[0065] prescription:

[0066] Domperidone 5g

[0067] Macrogol 6000 5g

[0068] Macrogol 4000 10g

[0069]Makes 1000 capsules

[0070] Preparation method: Take the fine powder of domperidone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten mixed matrix of polyethylene glycol 4000 and polyethylene glycol 6000, stir well, use simethicone oil as a coolant, and make pills by dropping , dried, that is.

[0071] 4. Example 4

[0072] prescription:

[0073] Domperidone 5g

[0074] Glyceryl monostearate 15g

[0075] Makes 1000 capsules

[0076] Preparation method: Take the fine powder of domperidone that has been ultrafinely pulverized and passed through a 200-mesh sieve, add it to the molten glyceryl monostearate base, mix well, use ice water as a coolant, make pellets by dropping, dry, and obtain.

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PUM

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Abstract

The present invention utilizes ultramicropulverization and dripping pill preparation production process to make domperiodine dripping pills, and can attain the goal of raising disintegration and dissolution speed, quickly obtaining therapeutic effect, raising stability of medicine, reducing dose of auxiliary material, reducing production cost and convenient administration. Said pill not only can be sucked, but also can be swallowed, and its compliance property is good.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to domperidone dripping pills and a preparation method thereof. Background technique [0002] Domperidone is a peripheral dopamine receptor blocker, acting directly on the gastrointestinal wall, increasing the tension of the lower esophageal sphincter, preventing gastroesophageal reflux, enhancing gastric motility, promoting gastric emptying, coordinating gastric and duodenal motility, inhibiting Nausea, vomiting, and can effectively prevent bile reflux without affecting gastric secretion. Domperidone does not easily pass through the blood-cerebrospinal fluid barrier and has no inhibitory effect on dopamine receptors in the brain. Therefore, it has no extrapyramidal and other neurological and mental adverse reactions. [0003] Domperidone is rapidly absorbed after oral administration, and the peak plasma concentration can be reached within 15 to 30 mi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/454A61P1/14
Inventor 钱进许军彭红李平朱丹刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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