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Recombination human interferon alpha-2b oral adhesive plaster and its making method

A technology of recombinant human interferon and interferon alpha, which can be used in sheet delivery, medical preparations containing active ingredients, peptide/protein ingredients, etc. The effect of the body's immunity

Inactive Publication Date: 2004-07-21
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Oral buccal tablets are a common dosage form for administration through the oral mucosa, but the buccal tablets generally dissolve in the mouth in about 5 minutes. Interferon, as a macromolecular substance, is absorbed slowly through the oral membrane. A very small amount of interferon can be absorbed and utilized

Method used

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  • Recombination human interferon alpha-2b oral adhesive plaster and its making method
  • Recombination human interferon alpha-2b oral adhesive plaster and its making method
  • Recombination human interferon alpha-2b oral adhesive plaster and its making method

Examples

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Effect test

Embodiment 1

[0032] Embodiment 1. Preparation of recombinant human interferon α-2b oral adhesive sheet

[0033] Material composition: Interferon α-2b (provided by Tianjin Hualida Bioengineering Co., Ltd., the same below) 2×10 8 A total of 75 grams of IU accessories, including:

[0034] Hypromellose (HPMC) 40%

[0035] Sodium Carboxymethyl Cellulose (CMC-Na) 15%

[0036] Carbopol 24.8%

[0037] Other 0.2%

[0038] Lactose 15%

[0039] Magnesium Stearate 5%

[0040] Preparation Process:

[0041] The whole process is carried out in a sterile room.

[0042] Weigh various auxiliary materials according to the prescription, firstly mix the various auxiliary materials evenly, pass through a 40-mesh sieve, and sterilize by ultraviolet irradiation for future use.

[0043] Weigh interferon α-2b, fully mix with about 4g of the auxiliary material mixture, add 40g of the auxiliary material mixture, mix well, and finally add the remaining auxi...

Embodiment 2

[0045] Embodiment 2. Preparation of recombinant human interferon α-2b oral adhesive sheet

[0046] Material composition: Interferon α-2b 1×10 8 IU

[0047] A total of 90 grams of auxiliary materials, including:

[0048] Hypromellose (HPMC) 28%

[0049] Sodium Carboxymethyl Cellulose (CMC-Na) 30%

[0050] Carbopol 15%

[0051] Lactose 15%

[0052] Magnesium Stearate 12%

[0053] The preparation process is the same as in Example 1, but the tablet weight is adjusted to 90 mg.

Embodiment 3

[0054] Embodiment 3. Preparation of recombinant human interferon α-2b oral adhesive sheet

[0055] Material composition: Interferon α-2b 5×10 8 IU

[0056] A total of 100 grams of auxiliary materials, including:

[0057] Hypromellose (HPMC) 20%

[0058] Sodium Carboxymethyl Cellulose (CMC-Na) 15%

[0059] Carbopol 23%

[0060] Lactose 30%

[0061] Magnesium Stearate 12%

[0062] The preparation process is the same as in Example 1, but the tablet weight is adjusted to 100 mg.

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Abstract

An oral picking for preventing and treating SARS is prepared from recombinant human interferon alpha-2b, hydroxypropylmethyl cellulose or carboxymethyl cellulose, and Kabopu through proportionally mixing and pressing. Its preparing process is also disclosed.

Description

1. Technical field [0001] The invention relates to recombinant human interferon alpha-2b and antiviral medicine. 2. Background technology [0002] Interferon is a kind of protein induced by human cells when they are infected by viruses, which has anti-virus, anti-cell proliferation and immune regulation. According to antigen specificity and molecular structure, interferon can be divided into three types: α, β, γ interferon, among which α type interferon can be divided into three types. [0003] The so-called natural interferon is induced and produced by human cells, some of which are leukocyte interferon derived from human blood. Due to the limited source of raw materials and difficult purification, the cost of preparing high-purity interferon is high and the yield is low. Moreover, there are potentially dangerous contaminations of hepatitis pathogens and HIV, which greatly limit the clinical application of interferon. In 1980, the United States successfully expressed the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K38/21A61P31/12A61P31/14
Inventor 沈子龙姚文兵高向东张陆勇
Owner CHINA PHARM UNIV
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