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Medical cosmetology transdermal absorption enhancer containing natural plant extracts

An absorption enhancer, a technology of natural plants, applied in the field of medical cosmetology, can solve the problems of azone irritation, long lag time onset, poor effect, etc., achieve efficient absorption, increase use value, and promote the effect of diffusion absorption

Inactive Publication Date: 2017-05-31
徐慧婷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A large number of documents prove that azone is a good transdermal absorption accelerator, which can effectively promote the transdermal absorption of drugs, but azone has some shortcomings such as irritation, long lag time for onset of action, and sometimes poor effect when used alone

Method used

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  • Medical cosmetology transdermal absorption enhancer containing natural plant extracts
  • Medical cosmetology transdermal absorption enhancer containing natural plant extracts
  • Medical cosmetology transdermal absorption enhancer containing natural plant extracts

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The specific steps of extracting plant essence from natural plant violet include:

[0045] (1) Choose fresh violet plants, wash them with tap water for the first time, then wash them with purified water, dry them and use a mechanical pulverizer to crush them into powder, and pass through a 30-mesh sieve to obtain crushed material;

[0046] (2) Add the crushed material to CO 2 Supercritical extraction is carried out in the supercritical extraction equipment, fluid extraction pressure is 40MPa, extraction temperature is 40℃, CO 2 The fluid flow rate is 1000L / h, the extraction time is 2h, and the violet crude oil is obtained;

[0047] (3) Freeze the crude violet oil at 8°C for 2 hours, and then use a high-speed centrifuge at a speed of 1200 to remove impurities to obtain the violet crude oil;

[0048] (4) Add 10 times the weight of water to the violet primary oil, and then use a rectifier for vacuum fractionation, and collect the organic phase to obtain the violet plant essence.

Embodiment 2

[0050] The steps of chemical modification and reduction of β-ionone to formula I include:

[0051] (1) Add 5 times the weight of β-ionone anhydrous ethanol and Pd / C catalyst to the reactor and use ultrasonic normal temperature radiation, and then add β-ionone and ammonium formate to continue the radiation. The molar ratio is 1:3, and TLC and GC are used to monitor the reaction to completion; the ultrasonic radiation power is 150W, and each radiation time is 10min.

[0052] (2) After the reaction is complete, the reaction solution is cooled and filtered. The Pd / C catalyst is recovered and dried for later use. The filtrate is used to remove the solvent with a rotary evaporator and an appropriate amount of saturated brine is added, and then extracted with ethyl acetate. The organic layers are combined and dried. The agent is dried with anhydrous sodium sulfate, filtered, and distilled to remove ethyl acetate. After purification, the active substance of formula I is obtained. The reac...

Embodiment 3

[0055] The preparation process of the finished product:

[0056] Add 50mg of violet plant essence and 30mg of active substance into sterile water to make the volume to 10ml, then sterilize and package into sterile bottle.

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Abstract

The invention discloses a medical cosmetology transdermal absorption enhancer containing natural plant extracts. The transdermal absorption enhancer comprises plant essence extracted from the natural plant violet, and an active ingredient as shown in formula I obtained through chemical reduction of beta-ionone. The solvent of the transdermal absorption enhancer is sterile water. The bioactive ingredients with good effects are extracted from natural plants and obtained through modification. The transdermal absorption enhancer can be added to existing professional skincare products or pharmaceutic preparations by an appropriate amount as needed, so as to promote fast diffusion and absorption of main ingredients of cosmetic products or drugs in skin and make skin symptoms improved and repaired quickly. The transdermal absorption enhancer can be widely added to skincare products. By enhancing the absorbance of active ingredients in existing cosmetic products, ordinary cosmetic products can be absorbed efficiently, and the using value of existing cosmetic products is increased.

Description

Technical field [0001] The invention relates to the technical field of medical cosmetology, in particular to a medical cosmetology transdermal absorption promoter containing natural plant essence. Background technique [0002] Transdermal penetration enhancers can promote the penetration and absorption of functional ingredients in cosmetics on the skin. The mechanism of transdermal absorption enhancer is mainly to reversibly change the skin structure to penetrate into the skin and reduce the resistance of the substance through the skin, so as to promote systemic absorption or local treatment. [0003] The existing transdermal penetration enhancers are mainly used in medicine and are widely used. Different from the medical field, the functional ingredients in cosmetics do not need to pass through the skin into the human body to circulate. For example, sunscreen functional ingredients only need to stay on the surface of the skin. For its efficacy, the whitening component exists in t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/35A61K47/46A61K47/08A61Q19/00
CPCA61K8/922A61K8/35A61K47/08A61K47/46A61K2800/10A61K2800/805A61Q19/00
Inventor 徐慧婷
Owner 徐慧婷
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