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Fenfibrate masticatory and its preparation

A technology of fenofibrate and chewable tablets, applied in the field of fenofibrate chewable tablets and its preparation, can solve problems such as inconvenient taking, low bioavailability, and drug dissolution rate can only reach 53.38%

Inactive Publication Date: 2004-07-07
四川维奥制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

With this preparation method, the particle size of fenofibrate cannot be made very small, and its drug dissolution rate can only reach 53.38%, and its bioavailability is low. It is necessary to take 300 mg every day, divided into three times, and it is inconvenient to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0081] 1. Weigh 200g of fenofibrate raw material and 200g of PEG6000 in a beaker, mix them evenly, heat in a water bath at 85°C, stir to make the fusion glass-like, add 2g of sodium lauryl sulfate, stir, and pour into pre-cooling In a stainless steel pan, it was rapidly cooled to 4°C to solidify within 10 minutes, dried at room temperature, pulverized, and passed through an 80-mesh sieve to obtain a solid dispersion powder for future use.

[0082] 2. Weigh 402g of solid dispersion powder, 150g of lactose, 50g of cross-linked polyvinylpyrrolidone, 40g of sodium carboxymethyl starch, 10g of aspartame, 2g of micropowder silica gel, and 2g of magnesium stearate, mix them in sequence, and pass through a 60-mesh sieve 3 times, mix well.

[0083] 3. Content measurement, tablet pressing and packaging.

[0084] The role of each excipient in the prescription

[0085] Polyethylene glycol 6000 solid dispersion carrier

[0086] Sodium Lauryl Sulfate Surfactant

[0087] lactose filler ...

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PUM

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Abstract

A chewing tablet of fenofibrate is prepared from fenofibrate, solid disperser as carrier, filler, disintegrant, flowing aid, lubricant, surfactant and sweetening agent through proportioning, heating the fenofibrate and carrier by water bath, quick cooling for solidifying, drying, breaking, mixing with others, and tabletting.

Description

Technical field: [0001] The invention relates to a tablet with fenofibrate as the main drug and a preparation method thereof. Background technique: [0002] Fenofibrate is a phenoxyaromatic acid lipid-lowering drug. The existing tablets with fenofibrate as the main drug are made of powder by crushing and sieving fenofibrate, and then adding suitable auxiliary materials to make a mixture , and then add soft materials to make dry granules, add adjuvant to the dry granules and mix them to make granules, and compress the granules to make fenofibrate ordinary tablets. With this preparation method, the particle size of fenofibrate cannot be made very small, its drug dissolution rate can only reach 53.38%, and its bioavailability is low. It needs to take 300 mg every day, divided into three times, which is inconvenient to take. Invention content: [0003] The object of the present invention is to provide a fenofibrate chewable tablet with high bioavailability, small side effects...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/215A61P3/06
Inventor 程天贵杨传珏吴庆江
Owner 四川维奥制药有限公司
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