Super saturated and soluble type skin administration medicinal composition substrate

A dissolving and matrix technology, applied in medical science, bandages, absorbent pads, etc., to achieve the effects of improving skin permeability, increasing effective utilization, and low cost

Inactive Publication Date: 2004-05-05
汪晴
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the shortcomings of the existing transdermal administration pressure-sensitive adhesive matrix, the present invention provides a supersaturated soluble transdermal administration pressure-sensitive adhesive matrix

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] In the existing pressure-sensitive adhesive preparations for percutaneous administration of estradiol, the concentration of estradiol in the pressure-sensitive adhesive is generally 1-2% by weight in the matrix content, mainly because of worrying about the crystallization of the drug in the pressure-sensitive adhesive. However, for preparations containing chemical accelerators in the matrix, the concentration of estradiol is generally below 1%. In this embodiment, a high concentration of 4% is used, and the most commonly used chemical accelerator is isopropyl myristate (IPM). Human skin allergy experiments show that 20% IPM will not have any adverse effects and sequelae on the skin.

[0016] Composition Weight %

[0017] Base Polyacrylate Pressure Sensitive Adhesive 66%

[0018] Estradiol 4%

[0019] Isopropyl myristate 20%

[0020] Crystallization Inhibitor 10%

[0021] Using the usual paste technique, the prepared matrix mother liquor is coated on the plastic fil...

Embodiment 2

[0025] Composition Weight %

[0026] Base Polyacrylate Pressure Sensitive Adhesive 44%

[0027] Prednisolone 4%

[0028] Oleic Acid 20%

[0029] Isopropyl myristate 20%

[0030] Crystallization Inhibitor 12%

Embodiment 3

[0032] Composition Weight %

[0033] Base Polyacrylate Pressure Sensitive Adhesive 76%

[0034] Melatonin 4%

[0035] Oleic acid (Polyethenosy oleyl alcohol 1) 10%

[0036] Crystallization Inhibitor 10%

[0037]

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PUM

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Abstract

An ultrasaturated dissolving type composite matrix for the percutaneously applied medicine is a pressure sensitive colloid containing chemical promoter and crystallizing inhibitor. It can make the medicine dissolve in ultrasaturated state and improve the penetrability of medicine to skin. Its advantages are high effect on increasing the curative effect of medicine and low cost.

Description

technical field [0001] The invention belongs to the dressing in the medicine category, and refers to a pressure-sensitive adhesive combination matrix which can keep the supersaturated dissolution of the medicine and also contains a chemical accelerator and a crystallization inhibitor. Background technique [0002] The transdermal delivery system (TTS) can avoid the first-pass effect of the drug on the liver and improve the biological availability of the drug. It is an advanced and effective route of drug delivery. Due to the hindering effect of the stratum corneum of the skin on drug penetration, it is difficult for many drugs to achieve the skin penetration rate that produces therapeutic effects, which limits the types of drugs that can be administered through the skin. In order to overcome the barrier of the stratum corneum of the skin, various physical and chemical means including chemical accelerators, ultrasound, iontophoresis, and electroporation have been used to chan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/20A61L15/24
Inventor 汪晴
Owner 汪晴
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