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Bear gall lozenge and preparing method thereof

A technology of bear bile and bear bile powder, which is applied to medical preparations containing active ingredients, pharmaceutical formulas, pill delivery, etc. It can solve the problems of easy moisture absorption, deliquescence, and single dosage form, and achieves convenient consumption and transportation , good taste effect

Inactive Publication Date: 2004-04-21
庄丽纯
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Domestic existing preparations only have "bear bile capsule" as a single drug preparation, and most of the others are compound preparations; and health care products mainly include bear bile powder (medicinal material) and bear bile wine in small packages, but due to their extremely bitter taste, Fishy, ​​easy to deliquescence, its consumption is all less, and this has just greatly limited and weakened its remarkable treatment, the practical effect of health care; The method of coating after making granules is solved, but so far there is no report on the method of fundamentally solving its bitterness, fishy smell, and easy moisture absorption problems, so the dose-effect of bear bile cannot be brought into full play, and single-flavored bear bile A single form of Chinese patent medicine

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0037] A. Weigh each raw material according to the ratio:

[0038] Bear bile powder 50g, cyclodextrin 75g, licorice extract 100g, starch 250g, dextrin 300g, sugar 4008g, stevioside 1.5g, menthol 8g, peppermint oil 5ml, lemon yellow 0.6 grams, 2.9 grams of sodium copper chlorophyllin, 8 grams of sodium glutamate, 150 grams of magnesium stearate, 40 grams of talcum powder.

[0039] B. Dissolve bear bile powder and cyclodextrin in water and an organic solvent respectively to make a solution, stir and clathrate at a temperature of 25°C to 80°C, recover the organic solvent, and then spray dry to obtain the clathrate.

[0040] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin, sodium glutamate, etc., make granules, dry, and granulate.

[0041] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve,

[0042] E. After taking C, add D and seal i...

example 2

[0045] A. Weigh each raw material according to the ratio:

[0046] Bear bile powder 80g, cyclodextrin 100g, starch 200g, dextrin 400g, sugar 4097g, licorice extract powder 50g, stevioside 1.0g, menthol 7g, peppermint oil 6ml, lemon Yellow 0.4 grams, sodium copper chlorophyllin 2.6 grams, sodium glutamate 6 grams, magnesium stearate 20 grams, talcum powder 30 grams.

[0047] B. Dissolve bear bile powder and cyclodextrin in water and an organic solvent respectively to make a solution, stir and clathrate at a temperature of 25°C to 80°C, recover the organic solvent, and then spray dry to obtain the clathrate.

[0048] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin, sodium glutamate, etc., make granules, dry, and granulate.

[0049] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve,

[0050] E. After taking C, add D and seal it for ...

example 3

[0053] A. Weigh each raw material according to the ratio:

[0054]Fresh bear bile 900ml, cyclodextrin 160g, starch 250g, dextrin 500g, sugar 3854g, licorice extract powder 60g, stevioside 1.0g, menthol 6.5g, peppermint oil 7ml, lemon Yellow 0.5g, sodium copper chlorophyllin 3g, sodium glutamate 8g, magnesium stearate 20g, talcum powder 40g

[0055] B. Dissolve bear bile powder and cyclodextrin in water and an organic solvent respectively to make a solution, stir and clathrate at a temperature of 25°C to 80°C, recover the organic solvent, and then spray dry to obtain the clathrate.

[0056] C. Mix the inclusion compound with starch, dextrin, sugar, licorice extract powder, stevioside, tartrazine, sodium copper chlorophyllin, sodium glutamate, etc., make granules, dry, and granulate.

[0057] D, get the volatile auxiliary material menthol and peppermint oil, add ethanol to dilute and make it dissolve,

[0058] E. After taking C, add D and seal it for more than 4 hours, add mag...

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PUM

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Abstract

A buccal lozenge of bear gall is prepared from bear gall powder, cyclodextrin and liquorice extract. Its advantages are less loss of bioactivity, high curative effect and agreeable taste.

Description

Technical field: [0001] The invention relates to a bear bile buccal tablet and a preparation method thereof. Background technique: [0002] Bear bile is the bile of the Ursidae black bear (Selenaretos Thibeta Cuver) or brown bear (Ursusaretos). Bear bile is one of the most valuable medicinal materials in the treasure house of traditional Chinese medicine in my country, and it has been used in clinical practice for thousands of years. According to the classics of traditional Chinese medicine "Shen Nong's Materia Medica", "Tang Materia Medica", and "Compendium of Materia Medica", bear bile is bitter in taste, cool in nature, returns to the spleen, gallbladder, heart meridian, non-toxic, and has the functions of clearing heat, calming the liver, and improving eyesight; Convulsions and convulsions, external treatment of red eyes, swelling and pain, and sore throat; the dosage is 0.3-1 g, mostly in the form of pills and powder, appropriate amount for external use, powdered or mi...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61P1/16A61P3/06A61P9/12A61P11/04A61P27/02
Inventor 庄丽纯谭养成
Owner 庄丽纯
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