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Prepn of super-paramagnetic polymer microsphere

A superparamagnetic and polymer technology, applied in chemical instruments and methods, inorganic pigment treatment, fibrous fillers, etc., can solve problems such as insufficient iron content, insufficient magnetism, and serious agglomeration, and achieve high product purity, Size-controllable, easily dispersed effects

Inactive Publication Date: 2004-01-21
北京倍爱康生物技术有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Careful analysis and experiments show that there are some deficiencies in this invention: (1) the coating type magnetic Fe3O4 particle aggregate prepared by precipitation method has certain lipophilicity, but the agglomeration is serious, and the dispersibility is not solved well, which is unfavorable for combining with olefin monolayers. miscible blending
(2) The particle size of the prepared Fe3O4 particles is not uniform, so that it is difficult to form uniform and stable droplets in the vinyl monomer, and finally it is difficult to prepare uniformly distributed microspheres
(4) The coating of microspheres is not tight enough, and the acid and alkali resistance is not good enough (5) The iron content is not high enough, and the magnetism is not strong enough, which is not conducive to the application in biomedicine and other fields

Method used

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  • Prepn of super-paramagnetic polymer microsphere
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Examples

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example 1

[0036] Example 1: Preparation of Coated Superparamagnetic Nano Ferric Oxide Particles by Improved Co-precipitation Method

[0037] Will weigh FeCl 2 1.7169 g of solid sample, FeCl 3 4.6465 grams and 0.9217 grams of aluminum nitrate are mixed liquid 58ml, 200ml are put into there-necked flask successively, then continue vacuuming and feed nitrogen, make reaction solution under the protection of nitrogen. The temperature of the prepared water bath is set to 40°C, the stirring speed is 1500r / min, the concentration of the ammonia solution is 1mol / l, and the amount of ammonia water added dropwise is 100ml in the whole process. Blend at original speed. Add the oleic acid of 8ml, continue reaction 45 minutes under original stirring speed. Take the sample out and wash it thoroughly with a large amount of absolute ethanol and water.

example 2

[0038] Example 2: Preparation of Coated Superparamagnetic Nano Ferric Oxide Particles by Improved Co-precipitation Method

[0039] Will weigh FeCl 2 1.5169 g of solid sample, FeCl 3 4.0465 grams and magnesium nitrate 0.5217 grams of mixed liquid 50ml, 200ml are put into there-necked flask successively, then continue to vacuumize and feed nitrogen, make reaction solution under the protection of nitrogen. The temperature of the prepared water bath is set to 35°C, the stirring speed is 1500r / min, the concentration of the ammonia solution is 1mol / l, and the amount of ammonia water added dropwise is 100ml in the whole process. Blend at original speed. The sodium oleate of 6ml was added, and the reaction was continued for 30 minutes at the original stirring speed. Take the sample out and wash it thoroughly with a large amount of absolute ethanol and water.

example 3

[0040] Example 3: Preparation of coated superparamagnetic polymer microspheres by microsuspension polymerization

[0041] Disperse the surface-modified magnetic particles in styrene to form a magnetic fluid, take about 8ml, mix with 4ml divinylbenzene, 0.4g benzoyl peroxide and ultrasonically disperse for about 1 hour, at the same time add 0.25g emulsifier Sodium lauryl sulfate and co-emulsifier cetyl alcohol 0.2g were sequentially added to 80ml water at 60°C. After stirring for a certain period of time, 0.015g sodium hydroxide was added to adjust the pH value between 9 and 1, and the dispersed magnetic The fluid is added dropwise into the reaction bottle, fully emulsified for a certain period of time to prepare a microemulsion, reacted for 40 minutes, then dropwise added a mixed solution of 4ml of methacrylic acid and 10ml of an aqueous solution containing 0.1g of potassium persulfate, and then polymerized for 3 hours. Ethanol, methanol, chloroform, water, etc. can be fully w...

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Abstract

The present invention provides the preparation process of super-paramagnetic polymer microsphere. The super-paramagnetic polymer microsphere consists of polyolefin polymerized with lipophilic olefin monomer and organic monomer with hydrophilic functional radical and coated nano magnetic grains of modified ferroferric oxide. The nano magnetic grains with one surface lipophilic layer can be well dispersed in organic matter to form magnetic fluid and dispersed inside polymer microsphere to obtain super-paramagnetism. The microsphere is regular and has size of 0.1-5 micron and has magnetic ferroferric oxide accounting for 0.5-40 wt% of the whole micro microsphere. The present invention has the advantages of simple preparation process, narrow microsphere size, regular appearance, high functional radical content, homogeneous magnetism, stable chemical performance and acid and alkali resistance.

Description

technical field [0001] The invention belongs to magnetic polymer composite materials, and particularly provides a superparamagnetic polymer microsphere and a preparation method thereof. Background technique [0002] In addition to the characteristics of polymer composite microspheres, superparamagnetic polymer microspheres can also be endowed with a variety of reactive functional groups on the surface through copolymerization and surface modification, such as -OH, -COOH, -CHO, -NH2 etc., and because of its superparamagnetism, it can be easily separated under an external magnetic field. Some foreign scholars call it a dynamic particle (dynabead). As a new type of functional polymer material, magnetic polymer microspheres are used in biomedicine such as Clinical diagnosis, enzyme labeling, targeted drugs, cytology such as cell labeling, cell separation, etc., and bioengineering such as enzyme immobilization have very broad application prospects. How to prepare monodisperse su...

Claims

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Application Information

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IPC IPC(8): C08F2/18C08F2/44C08K3/22C08L25/04C09C3/00
Inventor 刘祖黎张玉庆龚菲力崔跃忠姚凯伦徐海伦丁宗华刘振世陶晋王建明刘永基杜桂焕
Owner 北京倍爱康生物技术有限公司
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