Bone growth factor injection and its preparation method

Abstract

The present invention discloses a bone growth factor injection and its preparation method. It includes the following steps: firstly, preparing bone growth factor into solution or mixed suspension; then preparing heat-sensitive hydrogel carrier solution; combining above-mentioned two solutions and making them into injection liquor or freeze-dried product. After the injection is injected into the fracture zone, the coagulated gel can be quickly formed, the bone growth factor and gel composite can be retained in bone repairing zone so as to fully produce slowly-releasing effect-increasing and effect-prolonging action and can raise biological utilization rate of the bone growth factor can raise its bone-forming action.

Description

technical field [0001] The invention relates to a bone repair material, in particular to an injection for injecting bone growth factor into a fracture area to promote fracture repair and a preparation method thereof. Background technique [0002] The treatment of delayed fracture union and nonunion is a difficult problem in orthopedics. For the treatment of delayed union nonunion, the traditional method is to reduce the weight-bearing intensity or prolong the non-weight-bearing time, add external fixation, or use electromagnetic therapy. But these methods may recover slowly and take a long time to treat. The disadvantage of surgical bone grafting is that surgical implantation is required, which has the disadvantages of increasing trauma, inducing infection, and affecting joint and muscle functions. [0003] The lack of bone growth factor is one of the main causes of abnormal fracture healing. Bone growth factor has a strong osteoinductive effect, can act on mesenchymal ce...

AI Technical Summary

Problems solved by technology

As a result, bone morphogenetic protein may not easily remain in the fracture area, weaken the osteoinductive effect, or be lost to the muscle space to cause heterotopic ossification

Another Chinese patent also discloses the technology of using human fibrin as a bone growth factor carrier. The disadvantages are that the preparation and use are complicated, expensive, and blood products have the risk of spreading diseases such as hepatitis and AIDS.