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In-situ osteoplastic active calcium phosphate cement and its prepn and application

A technology of calcium phosphate bone cement and osteogenic activity, which is applied in the field of medical materials and can solve the problems of no osteogenic activity and BMP is not easy to play a role

Inactive Publication Date: 2003-05-14
SHANGHAI REBONE BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the clinical study, it was found that the material was partially degraded after 6 months of implantation, but the resorption and bone ingrowth of CPC were less than 30% after 12 months of follow-up. This is because the material only has the ability to guide new bone formation, but no bone formation. Activity's sake
It may be due to the fact that BMP is directly compounded in CPC. From the surface, it is not detected that the introduction of a small amount of protein affects the curing of CPC, but the acid-base reaction in the process of CPC hydration has a certain impact on biologically active factors, making BMP Difficult to function at low concentrations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Weigh 3g of self-curing calcium phosphate bone cement powder composed of calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite with a diameter of less than 20 μm, weigh 0.3g sodium alginate, 3mg water-insoluble BMP and 3mg FGF, 3mg TGF- β, Spray composite embedding to prepare microcapsules with a diameter of 500 μm, pour them into the powder, disperse evenly in the vessel, add 1.2g of normal saline, use a dental knife to mix and evenly form a mud mass, and place it at 37°C and 100°C % humidity environment to cure. The solidified body was implanted into the femoral condyle of 15 rabbits, no suppuration or abnormal exudation was found, and the biocompatibility was good. The concentrations of Ca and P in the peripheral blood of rabbits had no obvious fluctuation within 1 year after operation, and the activity of alkaline phosphatase returned to normal level after 90 days. The superficial layer of the material was significantly degraded 1 month after implan...

Embodiment 2

[0036] Weigh 3 g of self-curing calcium phosphate bone cement powder with a diameter of less than 20 μm consisting of calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite. Weigh 0.3g of collagen, 3mg of water-insoluble BMP, 3mg of FGF and 3mg of TGF-β, compound spraying and embedding to prepare inclusion bodies with a diameter of 50-1000μm, and pour them into the powder, disperse evenly in the vessel, add 1.2 g normal saline, mixed with a dental knife to evenly form a mud mass, and placed in a 37°C, 100% humidity environment to solidify. The solidified body was implanted into the femoral condyle of 15 rabbits, no suppuration or abnormal exudation was found, and the biocompatibility was good. The concentrations of Ca and P in the peripheral blood of rabbits had no obvious fluctuation within 1 year after operation, and the activity of alkaline phosphatase returned to normal level after 90 days. The superficial layer of the material was significantly degraded 1 ...

Embodiment 3

[0038] Weigh 3 g of self-curing calcium phosphate bone cement powder composed of calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite with a diameter less than 20 μm. Weigh 0.3g of hydroxycellulose, 1mg of water-insoluble BMP, 5mg of FGF, 3mg of TGF-β and other active complexes, compound embedding to prepare inclusion bodies or microcapsules with a diameter of 50-1000μm, and pour them into the powder , disperse evenly in the container, add 1.2g of physiological saline, use a dental spatula to evenly form a paste, and place it in an environment of 37°C and 100% humidity to solidify. The solidified body was implanted into the femoral condyle of 15 rabbits, no suppuration or abnormal exudation was found, and the biocompatibility was good. The concentrations of Ca and P in the peripheral blood of rabbits had no obvious fluctuation within 1 year after operation, and the activity of alkaline phosphatase returned to normal level after 90 days. The superficial layer ...

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Abstract

The present invention discloses an in-situ osteoplastic active calcium phosphate cement and its preparation process and application. Sodium alginate, collagen, hydrocellulose, polypeptide molecular beam, etc. are used to embed BMP, FGF, TGF-beta and other composite to maintain the activity of bioactive factor. Embedded bioactive factor is made to compound with CPC powder and mix with curing liquid to form paste capable of being moulded at will and self hardened in human body environment and humidity. Inside body, the bioactive factor can induce formation of blood vessel and new bone, formation of active tissue and functional reconstruction. The used CPC cured body may be used as calcium source and phosphorus source for forming new bone and speeding bone tissue formation. The present invention is applied for filling and repairing of bone.

Description

technical field [0001] The invention belongs to the field of medical materials, and relates to a calcium phosphate active bone cement hard tissue repair material which can be solidified in situ and can induce new bone formation. Background technique [0002] Delayed fracture union, bone nonunion, and repair of bone defects are major unresolved problems in the field of orthopedics for a long time. Bone transplantation is the main means and method for the treatment of bone defects, including autologous bone transplantation, allogeneic bone transplantation, organic polymeric bone cement and bioceramics. Wait. The effect of autologous bone grafting is certain, but its source is limited. This way of digging flesh to fill the sore and treating trauma with trauma will cause the patient to suffer the pain of the second operation and complications in the bone donor site; allogeneic bone grafting is another option (Including allogeneic, that is, human bones and heterogeneous, that is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/00
Inventor 刘昌胜陈芳萍杨果诗
Owner SHANGHAI REBONE BIOMATERIALS
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