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Method for preparing naproxen sodium release tablet

A technology of naproxen sodium and sustained-release tablets, which is applied in the field of chemical pharmacy, can solve the problems of complicated preparation process and high price, and achieve the effects of simple process operation, low cost and easy industrial production.

Inactive Publication Date: 2003-03-26
XINJIANG TEFENG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product has dual effects of immediate release and sustained release. It can take effect within 30 minutes in the body, relieve pain quickly, and has stable blood concentration, and the analgesic effect can last for 24 hours. It is very popular among patients, but the preparation process is complicated and expensive

Method used

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  • Method for preparing naproxen sodium release tablet
  • Method for preparing naproxen sodium release tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Take hypromellose K4M 7% as the sustained-release framework material, 90% naproxen sodium, and 2% sodium carboxymethyl starch as a release rate regulator, mix well, add 5% povidone ethanol solution as the binder to make soft material, Sieve, prepare wet granules, dry, granulate, add 1% magnesium stearate as a lubricant, and compress into tablets to make sustained-release tablets containing 412.5 mg of naproxen sodium.

Embodiment 2

[0034] Take hypromellose K15M 7% as a sustained-release framework material, 90% naproxen sodium, and 2% crospovidone as a release rate regulator, mix well, and add 5% ethyl cellulose ethanol solution as a binder to make a soft material , sieved, prepared wet granules, dried, granulated, added 1% magnesium stearate as a lubricant, compressed into tablets, and made into sustained-release tablets containing 500 mg of naproxen sodium.

Embodiment 3

[0036] Take hypromellose K100 M10% of sustained-release framework material, 84% of naproxen sodium, 2% of sodium carboxymethyl starch as a release rate regulator, and 3% of microcrystalline cellulose as a filler. After mixing evenly, add 1% hard Magnesium fatty acid is used as a lubricant, and it is directly compressed into a slow-release tablet containing 412.5 mg of naproxen sodium.

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Abstract

The preparation method of naproxen sodium slow-releasing tablet preparation adopts macromolecular substance hydroxypropyl methyl cellulose (HPMC) as skeletal material, uses naproxen sodium as active component and adding a certain quantity of release speed regulating agent, and adopts a certain scientific preparation process. Said invented product can quickly produce action, its medicine effect is strong, action time is long and toxic side effect is less, and it is similar to Naprelan control product in internal and external properties. Its process is simple and cost is low.

Description

technical field [0001] The invention belongs to the field of chemical pharmacy and relates to a pharmaceutical method, in particular to a preparation method of naproxen sodium sustained-release tablets. Background technique [0002] Naproxen is an antipyretic and analgesic drug successfully developed by Syntex Co. in the United States. It belongs to non-steroidal anti-inflammatory drugs. It is very popular among patients due to its good medical effect and low toxicity. . Naproxen Sodium (Naproxen Sodium) is the sodium salt of Naproxen, which has strong anti-inflammatory and analgesic effects. Its chemical structure is as follows, [0003] It is mainly used clinically to treat rheumatism, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, lumbar disc herniation and various mild and moderate pains. The curative effect of naproxen sodium is the same as that of naproxen, but after it enters the stomach, it immediately disperses in the gastric juice and precipitat...

Claims

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Application Information

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IPC IPC(8): A61K9/22A61K31/192A61P19/02A61P29/00
Inventor 方晓玲姬静王明坤沈央
Owner XINJIANG TEFENG PHARMA
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