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Suppository for controlling sexual spread of AIDS

An AIDS and suppository technology, applied in the field of medicine and health, can solve the problems of low absorption and utilization, large liver and kidney damage, etc., and achieve the effects of less toxic side effects and high bioavailability

Inactive Publication Date: 2002-07-10
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The former has strong side effects on bone marrow hematopoietic function; the latter has low absorption and utilization and great damage to liver and kidney

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 The suppository of the present invention is packaged as 2400 mg per capsule, which is a unit. Each unit contains 500 mg of zidovudine, 80 mg of surfactant, 100 mg of deodorant, and the rest is a suppository base. The active ingredient zidovudine is mixed with the surfactant glycol ester and the deodorant chlorophene in the molten cocoa butter base of the suppository, and the resulting mixture is poured into the cooled mold to obtain the desired suppository.

Embodiment 2

[0015] Example 2 The suppository of the present invention is packaged as 2400 mg per capsule, which is a unit. Each unit contains 300 mg of zidovudine, 500 mg of acyclovir, 100 mg of surfactant, 20 mg of deodorant, and the rest is a suppository base. Mix the active ingredients zidovudine, acyclovir, the surfactant glycerol ester, and the deodorant chlorophene in the molten suppository base glyceryl stearate, and pour the resulting mixture into the cooled mold , And get the suppository you need.

Embodiment 3

[0016] Example 3 The suppository of the present invention is packaged as 2400 mg per capsule, which is a unit. Each unit contains 200 mg of zidovudine, 100 mg of acyclovir, 300 mg of miconazole, 10 mg of surfactant, 100 mg of deodorant, and the rest is a suppository base. The active ingredients zidovudine, acyclovir, miconazole, the surfactant glycol ester, and the deodorant chlorophene are mixed in the molten suppository base sugar gel, and the resulting mixture is poured into the cooled In the model, the required suppository is obtained.

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PUM

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Abstract

The suppository for controlling sexual spread of AIDS contains Zidovudine and substrate and each grain of the suppository may also contains Aciclovir 0-500 mg, Amphotercin 0-50 mg, Miconazole 0-300 mg, surfactant 0-100 mg and deodorant 0-100 mg. It is applied locally to urogenital system and this results in less toxic side effect and high biological utilization. Its Aciclovir is converted in vivo into triphophate compound to interfere the duplication of herpes simple xvirus DNA and to inhibit herpes virus, cytomegalo virus and EB virus; Amphotercin is used for treating vaginalmucous membrane infection; and Miconazole has broad-spectrum antifungal function.

Description

Technical field [0001] The invention belongs to the field of medicine and health, and is a suppository aimed at the sexual transmission of AIDS and the treatment of AIDS and urinary tract infection. Background technique [0002] In 2001, the State Council issued the relevant document "China's Action Plan for Containment and Prevention of AIDS", which pointed out that "my country's AIDS and STD prevention and control work is still very severe, and the epidemic of AIDS and STDs is increasing rapidly." The number of people infected in my country has exceeded 600,000, according to experts It is estimated that if the rate is increased by 30% every year, by 2010, the number of AIDS patients in my country will reach 10 million. The prevention and treatment of AIDS is a major event related to the national economy and people's livelihood. [0003] There are three ways of transmission of AIDS: blood transmission, sexual transmission, and mother-to-child transmission. Studies have shown tha...

Claims

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Application Information

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IPC IPC(8): A61K31/7064A61P31/18
Inventor 肖庚富李姝谢亮刘利
Owner WUHAN UNIV
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