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Staphylococcus aureus metabolic product medicine oral preparation and its use

A technology for staphylococcus and metabolites, which is applied in the direction of drug combination, antibacterial drugs, pill delivery, etc. It can solve the problems of metabolites of Staphylococcus aureus that have not been found, and achieve the goal of improving immune function, enhancing the immune function of the body, and having few side effects Effect

Active Publication Date: 2006-11-08
XIEHE PHARMA FACTORY SHENYANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far no metabolites from Staphylococcus aureus have been found to be used in the treatment of other diseases or as oral preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Embodiment 1, preparation staphylococcus aureus metabolite drug oral preparation

[0030] The purchased commercially available Staphylococcus aureus metabolite "Gaojusheng" (produced by Shenyang Xiehe Biopharmaceutical Co., Ltd.) is the Staphylococcus aureus metabolite drug oral preparation Y-1 of the present invention.

[0031] The commercially available Staphylococcus aureus metabolite "Engefei" (Zhejiang Yaojiang Pharmaceutical Co., Ltd.) was purchased as the Staphylococcus aureus metabolite drug oral preparation Y-2 of the present invention.

[0032] The commercially available Staphylococcus aureus metabolite "Gaoshida" (Changchun Gaoshida Biopharmaceutical Co., Ltd.) was purchased as the Staphylococcus aureus metabolite drug oral preparation Y-3 of the present invention.

Embodiment 2-4

[0033] Embodiment 2-4, preparation of staphylococcus aureus metabolite drug oral preparation

[0034] (1) Culture medium preparation:

[0035] (i) Preparation of pig heart extract: take fresh pig heart, wash and crush it, add 5 times the amount of water for injection, heat to boil for 2 hours, place it at 4°C for 14 hours, and filter it with a Buchner funnel to obtain pig heart extract. liquid.

[0036] (ii) Take an appropriate amount of tryptone, soybean peptone, fish peptone, or casein peptone and sodium chloride, and dissolve thiamine with water. Add appropriate amount of pig heart infusion and sheep liver infusion (prepared according to the method in step (i)) obtained in step (i), add appropriate amount of water and mix well. Adjust the pH values ​​to 3, 4, and 4 with HCl solution, add 0.5% (g / ml) activated carbon by volume, boil for 1, 1.5, and 2 hours respectively under stirring, and remove the activated carbon by filtration. Use NaOH solution to adjust the pH value ...

Embodiment 5

[0050] Embodiment 5, preparation oral preparation of staphylococcus aureus metabolite drug

[0051] (i) Take fresh pig heart, wash it, crush it, add 2 times the amount of water for injection, place it at 4°C for 14 hours, heat it to boiling and keep it for 2 hours, and filter it with Buchner funnel quantitative filter paper to obtain the pig heart infusion.

[0052] (ii) Take an appropriate amount of casein peptone and sodium chloride, heat and dissolve it with water for injection, add an appropriate amount of pig heart infusion and magnesium sulfate obtained in step (i), add an appropriate amount of water for injection and mix well, and the composition becomes 1% casein peptone, 5 % pig heart infusion, 0.5% sodium chloride, 0.01% magnesium sulfate and 0.005% calcium chloride enrichment medium.

[0053] (iii) Inoculate the CGMCC0341 strain under sterile conditions on the agar slant surface of the culture medium consisting of 1% casein, 0.5% sodium chloride and 0.5% agar, and c...

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PUM

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Abstract

The present invention relates to orally taken medicine preparation for treating tumor, AIDS, diabetes and hepatitis B, stopping drug addiction, resisting virus and raising immunity and with less toxic side effect. The preparation contains original metabolic product liquid obtained with staphylococcus aureus through culture, sterilizing and filtering; or contains metabolic product of staphylococcus aureus with one or more of enterotoxin A, B, C1, C2, C3 and D and TSST-1 as the effective components in the content of 1-50 ng / ml. The preparation of the present invention has high curative effect.

Description

technical field [0001] The invention belongs to the technical field of biological products, and in particular relates to oral pharmaceutical preparations of staphylococcus aureus metabolites and applications thereof. technical background [0002] Staphylococcus aureus is a pathogenic bacterium that exists widely in nature and can produce a variety of toxins and enzymes, such as: hemolysin, leukocidin, epidermal lytic toxin, enterotoxin (Staphylococcal Enterotoxin, abbreviated as SE), toxic shock syndrome toxin I (Toxic Shock Syndrome Toxin 1, abbreviated as TSST-1), coagulase, DNase, protease, lipase, peptidase, etc. Enterotoxin is a soluble protein with a single polypeptide chain, which contains more amino acids such as lysine, tyrosine, aspartic acid and glutamic acid. It is not affected by trypsin, so after eating food contaminated with enterotoxin by mistake, it acts on the inner fat nerve receptor in the intestine, transmits it to the center, stimulates the vomiting ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/74A61K9/20A61K9/48A61P35/00A61P1/04A61P1/16A61P31/12A61P31/18A61P25/36A61P31/06
Inventor 陈巨余
Owner XIEHE PHARMA FACTORY SHENYANG
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