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Bifendate oral disintegration tablet and its preparing process

A technology of orally disintegrating tablets and bifendate, which is applied in pill delivery, digestive system, drug combination, etc., can solve the problems that patients are difficult to take, and achieve the effect of convenient taking, stable quality and good taste

Inactive Publication Date: 2006-04-12
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the dosage form, most oral preparations need to be taken with a lot of water, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Prescription

[0031] 1. Raw material - bifendate 25.0g;

[0032] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0033] 3. Filling agent - mannitol 53.5g;

[0034] Microcrystalline cellulose 5.0g;

[0035] 4. Flavoring agent - aspartame 1.0g;

[0036] Ginseng essence 1.0g;

[0037] 5. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;

[0038] Low-substituted hydroxypropyl cellulose (L-HPC) 4.0g;

[0039] 6. Glidant - micropowder silica gel 1.0g;

[0040] 7. Lubricant—sodium stearyl fumarate 1.0 g.

[0041] The total weight is 100g, and a total of 1000 pieces are made.

[0042] 2. Preparation method

[0043] 1) Take the bifendate raw material and pulverize it, granulate it with polyvinylpyrrolidone K-30, pass it through a 26-mesh sieve, and set aside;

[0044] 2) Pass the micropowdered silica gel, ginseng essence, microcrystalline cellulose and aspartame through a 40-mesh sieve respectively, mix evenly, then add the granulated bifendate granules,...

Embodiment 2

[0048] 1. Prescription

[0049] 1. Raw material - bifendate 25.0g;

[0050] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0051] 3. Effervescent agent - citric acid 12.5g;

[0052] Sodium bicarbonate 10.0g;

[0053] 4. Filling agent - mannitol 28.0g;

[0054] Silicified microcrystalline cellulose (PROSOLV SMCC) 5.0 g;

[0055] 5. Flavoring agent - aspartame 1.0g;

[0056] Orange essence 1.0g;

[0057] 6. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;

[0058] Low-substituted hydroxypropyl cellulose (L-HPC) 5.0g;

[0059] 7. Glidant - micropowder silica gel 1.0g;

[0060] 8. Lubricant—1.0 g of sodium stearyl fumarate.

[0061] The total weight is 100g, and a total of 1000 pieces are made.

[0062] 2. Preparation method

[0063] 1) Mix bifendate and citric acid raw materials and pulverize, granulate with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;

[0064] 2) Take sodium bicarbonate and pulverize it, granulate it with polyvinylp...

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Abstract

The present invention relates to one kind of orally disintegrated bifendate tablet for treating chronic unresolved hepatitis accompanied by abnormal or chemically elevated ALT and other diseases, and its preparation. The orally disintegrated bifendate tablet is prepared with bifendate as main material, and through adding stuffing, disintegrating agent, corrective, flow assistant and other supplementary material, pressing into tablet and other steps. The present invention has the features of low production cost, fast disintegration, good taste, etc.

Description

[technical field] [0001] The invention relates to a bifendate orally disintegrating tablet preparation which can be used for treating chronic persistent hepatitis accompanied by abnormal increase of alanine aminotransferase (ALT) or ALT increase caused by chemical drugs. [Background technique] [0002] Bifendate is an enzyme-lowering drug for the treatment of hepatitis and an intermediate for the synthesis of Schisandra C. Oral administration of this product can reduce the increase of serum alanine-based transferase caused by carbon tetrachloride and thioacetamide, and this product can also enhance liver detoxification function, reduce liver pathological damage, promote liver cell regeneration and protect liver cells , thereby improving liver function. This product has a certain effect on the improvement of the main symptoms of hepatitis, such as liver pain, fatigue, abdominal distension, etc., but has no effect on the change of hepatosplenomegaly. It is clinically applica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/357A61K9/20A61P1/16
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
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