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Biological active nano titanium oxide ceramic for hard tissue repairing and its preparing method

A bioactive, titanium oxide technology, applied in the field of biomedical material preparation, can solve the problems of restricting the use of low- and middle-income patients, high cost of bioactive glass, and high cost, and achieve the effect of reducing economic burden, easy realization, and convenient operation

Inactive Publication Date: 2006-02-15
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main problems that bioactive materials for hard tissue repair are facing are: first, the particles produced by degradation or wear of bioactive materials after implantation in the body may cause infection at the implantation site; The cost is high, among which the market price of hydroxyapatite is at least 5,000 RMB / kg, and the cost of bioactive glass and bioactive metal is higher, thus limiting the use of low- and middle-income patients

Method used

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  • Biological active nano titanium oxide ceramic for hard tissue repairing and its preparing method

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Effect test

Embodiment 1

[0023] The invention prepares bioactive titanium oxide ceramics, adopts rutile nano-titanium oxide powder as raw material, adds 2.5% by mass percentage of magnesium oxide powder as a grain growth inhibitor, and uses analytical pure alcohol as a solvent to mix rutile nano-titanium oxide powder with oxidation Submerge the magnesium powder in alcohol, and then use an ultrasonic generator to fully mix the above powder under the action of ultrasonic waves for 10 minutes, then dry it at room temperature, and use a cold isostatic press under 50MPa pressure to dry the mixed powder Then put the formed green body into the muffle furnace for sintering, and raise it to the holding temperature at a heating rate of 10°C / min. At this time, the holding temperature is 1000°C. After holding at the holding temperature for 2 hours, cool with the furnace At room temperature, titanium oxide ceramics with both biological activity and crystallization can be obtained.

Embodiment 2

[0025] Using anatase nano-titanium oxide powder as raw material, adding 5% alumina powder as a grain growth inhibitor, using analytical pure alcohol as a solvent, submerging anatase nano-titanium oxide powder and alumina powder In alcohol, use an ultrasonic generator to fully mix the above powder for 20 minutes under the action of ultrasonic waves, and then dry it at room temperature. Use a cold isostatic press to shape the dried mixed powder under a pressure of 150 MPa, and then put The shaped green body is put into a muffle furnace for sintering, and is raised to the holding temperature at a heating rate of 50°C / min, and the holding temperature is 600°C at this time. After being kept at the heat preservation temperature for 5 hours, and then cooled to room temperature with the furnace, a titanium oxide ceramic having both biological activity and crystallization can be obtained.

Embodiment 3

[0027] Using composite nano-titanium oxide powder with rutile powder and anatase powder as raw material, adding calcium pyrophosphate powder with a mass percentage of 1% as a grain growth inhibitor, and using analytical pure alcohol as a solvent, the above two composite powders Submerge the material and calcium pyrophosphate powder in alcohol, and then use an ultrasonic generator to fully mix the above powder under the action of ultrasound for 30 minutes, then dry it at room temperature, and use a cold isostatic press under 200MPa pressure to dry the The mixed powder is formed, and then the formed green body is sintered in a muffle furnace, and the temperature is raised to the holding temperature at a heating rate of 10°C / min, and the holding temperature is 1200°C at this time. After being kept at the heat preservation temperature for 3 hours, and then cooled to room temperature with the furnace, a titanium oxide ceramic having both biological activity and crystallization can b...

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Abstract

The bioactive nano titania ceramic block is prepared with nano titania powder meeting biological and medical requirement, such as rutile powder and / or anatase powder, as main material, and through mixing with magnesium oxide powder, alumina powder, calcium pyrophosphate or other crystal growth inhibitor, cold isostatic pressing formation, and sintering. Under intracorporal physiological environment condition, the ceramic block can adsorb calcium and phosphorus ion to form surface bone apatite layer for bioactive chemical combination with bone tissue. The bioactive nano titania ceramic may be implanted into tooth or other bone fault cavity to form bioactive combination safely and reliably in relatively low cost.

Description

1. Technical field [0001] The invention relates to biomedical material preparation technology, in particular to a bioactive titanium oxide ceramic for hard tissue repair and a preparation method thereof. 2. Background technology [0002] Bioactive materials for hard tissue repair refer to materials that chemically combine with bone tissue through the formation of a bone-like apatite interface layer after implantation. Before the present invention was made, bioactive materials widely used in human hard tissue repair included hydroxyapatite ceramics, bioactive glass, surface-modified bioactive metals, and the like. These materials are implanted into the bone, and the chemical combination of bioactivity is realized by forming a bone-like apatite interface layer on the interface between the implanted bioactive material and the bone tissue. The main problems that bioactive materials for hard tissue repair are facing are: first, the particles produced by degradation or wear of bi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/10C04B35/46
Inventor 杨帮成虞奇峰吴尧张兴栋
Owner SICHUAN UNIV
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