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Preparation method and application of controllable degradation tissue reconstruction and repair material

A technology for repairing materials and tissues, applied in the field of controllable degradation of biomedical materials, can solve problems such as poor shape, difficulty in maintaining three-dimensional space, and inability to meet clinical needs

Pending Publication Date: 2022-08-05
广东博尔雅生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, expensive imported tissue engineering filling materials are mainly used clinically. Most of the raw materials come from animals, and there are certain risks of immunogenicity and cross-infection; In addition, there is a certain tension after the mucosa is sutured, and tissue edema during the healing process increases the tension, so it is difficult to maintain a three-dimensional space, resulting in slow formation of new tissue and poor shape, which cannot meet clinical needs.

Method used

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  • Preparation method and application of controllable degradation tissue reconstruction and repair material
  • Preparation method and application of controllable degradation tissue reconstruction and repair material
  • Preparation method and application of controllable degradation tissue reconstruction and repair material

Examples

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preparation example Construction

[0022] The present application provides a method for preparing a controllable degradable tissue reconstruction and repair material, comprising the following steps:

[0023] Step 1: Dissolving hydroxyapatite (HA) in water to obtain a hydroxyapatite suspension.

[0024] In the above steps, the concentration of the hydroxyapatite suspension is: the hydroxyapatite of 3-9g (such as 3g, 5g, 7g, 9g, preferably 3g) is dissolved in 20-100mL (such as 20mL, 40mL, 60mL, 80mL, 100 mL, preferably 20 mL) water. The water is distilled water.

[0025] The above steps are specifically: the water is placed in the container, the container is placed on the magnetic stirrer, and the stirring speed is 5-10 rev / sec (such as 5 rev / sec, 7 rev / sec, 10 rev / sec, preferably 10 rev / sec). rev / sec), add hydroxyapatite dropwise to the container at a rate of 2-3 drops / min (such as 2 drops / min, 3 drops / min), after the dropwise addition of hydroxyapatite, homogenize 3 -5h (such as 3h, 4h, 5h, preferably 3h) to...

Embodiment 1

[0043] Step 1. Preparation of PLGA:

[0044] Accurately measure a certain amount of viscous liquid stannous isooctanoate, dissolve it in dichloromethane, and prepare a solution with a concentration of 1g / mL. Add 180g 82:18 monomer lactide and glycolide, 0.3mL molecular weight regulator tert-butyldimethylsilanol (commercial product), and 8mL above 1g / mL initiator stannous isooctanoate into the sealed tube of dichloromethane solution. The sealed tube was repeatedly evacuated and protected by argon gas, so that the pressure of the sealed tube reached 10 -3 pa. The sealed tube was placed in a 160 °C incubator, and the reactants in the sealed tube were melted after 5 h of reaction, and then shaken every 10 min for more than three times, and then reacted for 5 h. The product in the sealed tube was subjected to suction filtration with an intensity of 1 Mpa, and the obtained filter residue was dried at 60° C. for 3 hours to obtain PLGA.

[0045] Step 2. Preparation of controllable...

Embodiment 2

[0049] Step 1. Preparation of PLGA:

[0050] Accurately measure a certain amount of viscous liquid stannous isooctanoate, dissolve it in dichloromethane, and prepare a solution with a concentration of 0.5g / mL. Add 160g 50:50 monomer lactide and glycolide, 0.2mL molecular weight regulator tert-butyldimethylsilanol (commercially available product), and 10mL above 0.5g / mL initiator isooctoate into the sealed tube Tin in dichloromethane. The sealed tube was repeatedly evacuated and protected by argon gas, so that the pressure of the sealed tube reached 10 -3 pa. The sealed tube was placed in a 140°C incubator, and the reactants in the sealed tube were melted after reacting for 6 h, then shaken every 15 min for more than three times, and then reacted for 10 h. The product in the sealed tube was subjected to suction filtration with an intensity of 1.5 Mpa, and the obtained filter residue was dried at 80° C. for 4 hours to obtain PLGA.

[0051] Step 2. Preparation of controllable...

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Abstract

The invention discloses a preparation method and application of a controllable degradation tissue reconstruction and repair material, and the preparation method comprises the following steps: dissolving hydroxyapatite in water to obtain a hydroxyapatite suspension; dissolving a polylactic acid-glycolic acid copolymer in a solvent to obtain a copolymer solution; dropwise adding a hydroxyapatite suspension into the copolymer solution, and adding absolute ethyl alcohol into the obtained emulsion to obtain a suspension; and refrigerating and filtering the suspension, and washing and drying the obtained filter residue to obtain the controllable degradation tissue reconstruction and repair material. Bone meal and bone blocks prepared from the controllable degradation tissue reconstruction and repair material are most suitable for balance of in-vivo scaffolds and degradation, the porosity is 85% or above, controllable degradability is achieved, and the degradation time is 2-3 months. The controllable degradation tissue membrane used for tissue repair and prepared from the controllable degradation tissue reconstruction and repair material has controllable degradability, and the degradation time is 1-3 months.

Description

technical field [0001] The present application relates to the field of controllable degradable biomedical materials, in particular to a preparation method and application of a controllable degradable tissue reconstruction and repair material. Background technique [0002] At present, expensive imported tissue engineering filling materials are mainly used in clinical practice. Most of the raw materials come from animals, and there are certain risks such as immunogenicity and cross-infection. The artificial bone powder used in clinical practice is in the form of fine sand, which is free from raw materials. In addition, there is a certain tension after the mucosa is sutured, and tissue edema also increases the tension during the healing process, so it is difficult to maintain the three-dimensional space, resulting in a slow rate of new tissue formation and poor shape, which cannot meet clinical needs. . [0003] Polylactic acid-glycolic acid copolymer (PLGA) is randomly polyme...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/58
CPCA61L27/58A61L27/46A61L27/56A61L2430/02C08L67/04
Inventor 高淑春郑碧霄王秋实
Owner 广东博尔雅生物科技有限公司
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