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Temperature-sensitive cyclodextrin polyrotaxane, and gel and preparation method thereof

A technology of polyrotaxane gel and cyclodextrin, which is applied in the field of temperature-sensitive polyrotaxane gel and its preparation, and can solve the problems of cyclodextrin primitives not having intelligent response characteristics, weak material response ability, and wheel slippage problems such as resistance to rotational movement

Active Publication Date: 2020-10-23
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, cyclodextrin polyrotaxanes are hindered in the slipping and turning motion of the wheel due to strong hydrogen bonding, and the solubility of the material is poor.
At the same time, its intelligent behavior is mainly controlled by the supramolecular structure of rotaxane, the cyclodextrin unit does not have intelligent response characteristics, and the response ability of the material is weak

Method used

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  • Temperature-sensitive cyclodextrin polyrotaxane, and gel and preparation method thereof
  • Temperature-sensitive cyclodextrin polyrotaxane, and gel and preparation method thereof
  • Temperature-sensitive cyclodextrin polyrotaxane, and gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0032] In this example, see figure 1 , using different end-capping groups to prepare polyrotaxanes that undergo controllable chain-degradation under specific external stimuli, and modify alkoxy ethers and hydrazide units on cyclodextrins, the number of cyclodextrins in polyrotaxanes, The number of alkoxy ether units and hydrazide units on each cyclodextrin is shown in Table 1, where PRX UV -DEG 9.6 -N 1.4 Dissociated polyrotaxanes by UV light, PRX red -DEG 9.3- N 0.6 For the reduction of dissociated polyrotaxanes, PRX non-DEG 8.4 -N 0.7 It is a non-degradable polyrotaxane.

[0033] Table 1. Characterization of PRXs

[0034]

Embodiment 2

[0036] In this embodiment, a method for preparing a temperature-sensitive slip gel that stimulates dissociation, the steps are as follows:

[0037] Sliding gels were prepared by using the hydrazide linkage reaction between hydrazide and aldehyde groups, and polyethylene glycol dibenzyl aldehyde (PEG-CHO) was used as a cross-linking agent. The specific experimental steps are as follows: First, prepare a buffer solvent of sodium acetate and acetic acid with pH = 4.53, and then weigh the polyrotaxane PRX-DEG-N and PEG-CHO obtained in Example 1, wherein hydrazide: aldehyde group = 1 :1 (molar ratio), add the mixed solvent of pH=4.53:THF=1:1 to dissolve completely (solid content is 15wt%), finally the solution of two substances is mixed in the ice bath, make it fully with the shaker Mix and let stand overnight in a 5°C refrigerator. Crack the glass sample bottle of the prepared gel, take out the prepared gel, place it in THF and deionized aqueous solution, replace the solvent 3-4 ...

Embodiment 3

[0043] In this embodiment, carry out slip gel rheological property test:

[0044] Different types of polyrotaxane gels prepared in Example 2 were subjected to rheological tests. The prepared slip gel has an average sample diameter of 10 mm and a thickness of 4 mm. Use a rotational rheometer to perform a frequency sweep on the gel sample, with a fixed strain of 0.5%, and a frequency range of 0.1-100rad / s. The rheological properties are as follows: figure 1 As shown, the storage modulus G' of Gel 1 and Gel 2 is about 960Pa, while the storage modulus of Gel 3 is 2870Pa.

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Abstract

The invention discloses temperature-sensitive cyclodextrin polyrotaxane, and a gel and a preparation method thereof. According to the temperature-sensitive cyclodextrin polyrotaxane gel capable of being degraded under stimulation, alkoxy ether modified cyclodextrin polyrotaxane is adopted as a matrix, a gel network is formed through a cross-linking reaction among cyclodextrin elements, and controllable linkage degradation of the gel is realized through cooperative usage of a stimulation fracture design of an end-capping group. The alkoxy ether modified cyclodextrin elements can dynamically slide along the main chain of a polymer and generate LCST phase transformation under a heating condition, so the volume of the gel is reduced; and meanwhile, under the action of a specific stimulation source, the end-capping group of the polyrotaxane is cracked, and the cyclodextrin elements fall off from the chain, so the gel network is dissociated, and gel-solution conversion is generated. Based onexcellent temperature responsiveness and controllable degradation property, the polyrotaxane gel has important application value in the aspects of drug delivery, intelligent biological materials, drivers and the like.

Description

technical field [0001] The invention belongs to the technical field of bionic intelligent response materials, and specifically relates to a temperature-sensitive polyrotaxane gel based on stimulus dissociation and a preparation method thereof. Background technique [0002] Cyclodextrin polyrotaxane is a kind of supramolecular system composed of polymer as the axis passing through the inner cavity of cyclodextrin, and macrocyclic main molecules are capped at both ends of the polymer chain. control features. Various functionalized cyclodextrin polyrotaxanes, such as pH value, temperature, and ion response, have been reported, which can be used in injectable hydrogels, micro / nano micelles, molecular machines, slip gels, high-strength Elastomers, bulk materials and biomedical materials, etc. [0003] Yui et al. used PEI-PEG-PEI triblock copolymer as the main chain to prepare pH-responsive polyrotaxanes (Yui, N.etal.Macromolecules.2005,38(23),9878.), when the pH value changes, ...

Claims

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Application Information

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IPC IPC(8): C08B37/16C08J3/075C08J3/24C08L5/16C08L71/02
CPCC08B37/0015C08J3/075C08J3/246C08J2305/16C08J2371/02
Inventor 闫家涛陈佩芸朱丽郑书东刘坤张阿方
Owner SHANGHAI UNIV
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