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Fully-degradable heart occluder coating for promoting cardiac muscle tissue repair and preparation method of fully-degradable heart occluder coating

A tissue repair and total degradation technology, applied in coating, medical science, surgery, etc., can solve the problems of adverse cardiac function recovery of myocardial cells, excessive fibrosis of myocardial tissue defects, thrombosis and other problems, and achieve good biocompatibility Sexual and biological activity, the effect of improving therapeutic performance

Active Publication Date: 2022-07-29
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, after the material is implanted in the heart, it will inevitably cause endothelial damage, further cause blood lipid deposition and thrombosis, and induce different degrees of inflammatory response
In addition, the excessive fibrosis of cardiomyocytes at the material implantation site is also not conducive to the effective recovery of cardiac function.
Therefore, the surface modification of existing cardiac occluder materials, endowing it with a layer of multi-functional coating with both endothelial, cardiac and anti-inflammatory effects is expected to improve the slow healing of myocardial defects and myocardial tissue damage. excessive fibrosis

Method used

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  • Fully-degradable heart occluder coating for promoting cardiac muscle tissue repair and preparation method of fully-degradable heart occluder coating
  • Fully-degradable heart occluder coating for promoting cardiac muscle tissue repair and preparation method of fully-degradable heart occluder coating
  • Fully-degradable heart occluder coating for promoting cardiac muscle tissue repair and preparation method of fully-degradable heart occluder coating

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A fully degradable cardiac occluder coating for promoting myocardial tissue repair is realized by amino amplification and amidation reaction, and the preparation process is as follows:

[0039] (1) The degradable polymer PDO base material is cleaned and dried for later use;

[0040] (2) Prepare a dopamine hydrochloride solution with a concentration of 1 mg / mL with a buffer solution, then place the cleaned and dried substrate material in the above dopamine solution, react at room temperature for 12 hours, and ultrasonically clean with deionized water to remove weak adsorption. , and finally dried under nitrogen to prepare polydopamine-pretreated multifunctional surfaces.

[0041] (3) Prepare a poly-lysine solution with a concentration of 10 mg / mL with a buffer solution, then react the polydopamine-modified substrate material with the amino-rich solution, react at room temperature for 2 hours, and shake and wash with deionized water. The poorly adsorbed components were r...

Embodiment 2

[0044] A fully degradable cardiac occluder coating for promoting myocardial tissue repair is realized by amino amplification and amidation reaction, and the preparation process is as follows:

[0045] (1) The polylactic acid base material is cleaned and dried for subsequent use;

[0046] (2) Prepare an EGCG solution with a concentration of 4 mg / mL with N-tris(hydroxymethyl)methylglycine buffer solution, then place the cleaned and dried substrate material in the above EGCG solution, react at room temperature for 4 hours, and use Deionized water was ultrasonically cleaned to remove weakly adsorbed components, and finally dried under nitrogen to obtain a polypolyphenol-pretreated multifunctional surface.

[0047](3) A polyarginine solution with a concentration of 10 mg / mL was prepared with N-tris(hydroxymethyl)methylglycine buffer solution, and then the polyphenol-modified substrate material was reacted with the above amino-rich solution, at room temperature The reaction was car...

Embodiment 3

[0050] A fully degradable cardiac occluder coating for promoting myocardial tissue repair is realized by amino amplification and amidation reaction, and the preparation process is as follows:

[0051] (1) The PDO base material is cleaned and dried for later use;

[0052] (2) A tannic acid solution with a concentration of 2 mg / mL was prepared with Tris-HCl buffer solution, then the cleaned and dried substrate material was placed in the above tannic acid solution, reacted at room temperature for 2 hours, and ultrasonicated with deionized water. Washing to remove the components with weak adsorption, and finally drying under nitrogen conditions to prepare polytannic acid pretreated multifunctional surface.

[0053] (3) Use Tris-HCl buffer solution to prepare a polyethyleneimine solution with a concentration of 20 mg / mL, then react the base material modified with tannic acid with the above amino-rich solution, react at room temperature for 4 hours, and use deionized water. Shake a...

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Abstract

The invention discloses a fully-degradable heart occluder coating capable of promoting cardiac muscle tissue repair and a preparation method of the fully-degradable heart occluder coating. The preparation method comprises the following steps: (1) cleaning a substrate material; (2) pretreating a substrate material polyphenol; (3) aminating the surface of the substrate material; and (4) introducing the activated recombinant collagen to the surface of the substrate material. The extracellular matrix bionic coating based on the recombinant collagen is constructed by activating a substrate material through a polyphenol compound, introducing a polyamino compound and further effectively loading a recombinant collagen component on the surface of the material through an amino amplification effect. Growth of endothelial cells and cardiac muscle cells at a defective part is realized, and inflammatory response is reduced, so that the purpose of effectively promoting regeneration and repair of defective cardiac muscle tissues is achieved.

Description

technical field [0001] The invention belongs to the technical field of biomedical material preparation, in particular to a fully degradable cardiac occluder coating for promoting myocardial tissue repair and a preparation method thereof. Background technique [0002] Ventricular septal defect (VSD) / atrial septal defect (ASD) is a common structural congenital heart disease. With the development of interventional closure devices and percutaneous catheter technology, cardiac occluder interventional closure therapy has become the most widely accepted cardiac defect treatment in the world due to its advantages of low risk, short operation time, less trauma, quick recovery, and fewer complications. treatment approach. So far, non-degradable metal-based and fully degradable polymer-based cardiac occluders have been used in clinical practice. Non-degradable metals, which persist in the body forever, may adversely affect the subsequent life of pediatric patients, so fully degradabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/10A61L31/14
CPCA61L31/10A61L31/08A61L31/148A61L31/14A61L2420/02A61L2420/08A61L2400/18C08L89/00
Inventor 王云兵杨立罗日方秦玉梅吴豪爽陈诺亚
Owner SICHUAN UNIV
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