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Preparation method of emplastrum matrix capable of rapidly releasing volatile drugs

A plaster and matrix technology, applied in the field of pharmaceutical preparations, can solve the problems of waste of resources, insufficient release of drug dosage, etc., and achieve the effects of reducing waste of resources, significant social and economic benefits, and simple preparation methods

Active Publication Date: 2022-07-29
HENAN LINGRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the above situation, in order to overcome the defects of the prior art, the purpose of the present invention is to provide a preparation method of plaster matrix for quick release of volatile drugs, which can effectively solve the problem of When the existing plaster is used, the dose cannot be fully released, resulting in a waste of resources

Method used

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  • Preparation method of emplastrum matrix capable of rapidly releasing volatile drugs
  • Preparation method of emplastrum matrix capable of rapidly releasing volatile drugs
  • Preparation method of emplastrum matrix capable of rapidly releasing volatile drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] A method for preparing a patch base for rapid release of volatile drugs, comprising the following steps:

[0020] (1), the synthesis of linear SIS block copolymer:

[0021] a. Heating and baking the reaction kettle and replacing it with nitrogen repeatedly to anhydrous and oxygen-free, then cooling to room temperature, then adding 1900mL cyclohexane to the reaction kettle, then adding 23g styrene, 1ml tetrahydrofuran and 5mL successively to a concentration of 1.5×10 -5 mol / L of n-butyllithium, the reaction kettle was heated to 40°C to initiate the first block polymerization reaction, and the reaction was carried out under the condition of 200rpm for 35min;

[0022] b. After the first block polymerization is completed, it is cooled to 25°C, and under nitrogen protection, 440g of isoprene monomer is added to the reaction kettle, and the temperature is raised to 45°C to initiate the second block polymerization reaction, and under the condition of 200rpm Stir the reaction ...

Embodiment 2

[0027] A method for preparing a patch base for rapid release of volatile drugs, comprising the following steps:

[0028] (1), the synthesis of linear SIS block copolymer:

[0029] a. Heating and baking the reaction kettle and replacing it with nitrogen repeatedly to anhydrous and oxygen-free, then cooling to room temperature, adding 2000 mL of cyclohexane to the reaction kettle, and then adding 25 g of styrene, 1.2 ml of tetrahydrofuran and 6 mL to a concentration of 1.5× 10 -5 mol / L of n-butyllithium, the reaction kettle was heated to 43 ° C, the first block polymerization was initiated, and the reaction was carried out under the condition of 230 rpm for 32 min;

[0030] b. After the first block polymerization is completed, it is cooled to 25 ° C, and under nitrogen protection, 450 g of isoprene monomer is added to the reaction kettle, and the temperature is raised to 48 ° C to initiate the second block polymerization reaction. Under the condition of 230 rpm Stir the reacti...

Embodiment 3

[0035] A method for preparing a patch base for rapid release of volatile drugs, comprising the following steps:

[0036] (1), the synthesis of linear SIS block copolymer:

[0037] a. Heating and baking the reaction kettle and replacing it with nitrogen repeatedly to anhydrous and oxygen-free, then cooling to room temperature, then adding 2100 mL of cyclohexane to the reaction kettle, then adding 26 g of styrene, 1.4 ml of tetrahydrofuran and 7 mL of 1.5× 10 -5mol / L of n-butyllithium, the reaction kettle was heated to 45 ° C, the first block polymerization was initiated, and the reaction was carried out under the condition of 250 rpm for 30 min;

[0038] b. After the first block polymerization is completed, it is cooled to 25°C, and under nitrogen protection, 460g of isoprene monomer is added to the reaction kettle, and the temperature is raised to 50°C to initiate the second block polymerization reaction. Under the condition of 250rpm Stir the reaction for 35min;

[0039] c...

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Abstract

The invention relates to a preparation method of an emplastrum matrix capable of rapidly releasing volatile drugs, the emplastrum matrix is prepared by matching an SIS framework material with liquid paraffin, an antioxidant BHT and hydrogenated rosin glyceride, and the preparation method comprises the following steps: (1) synthesizing a linear SIS block copolymer; b, after the first block polymerization is completed, initiating a second block polymerization reaction; c, after the second block polymerization is completed, initiating a third block polymerization reaction; d, after the third block polymerization reaction is finished, 900-1100 ml of absolute methanol is added to terminate the reaction to obtain an SIS elastomer, the SIS elastomer is placed in a vacuum oven and dried at 48-52 DEG C for 10-14 h, and the dried SIS elastomer is obtained; and (2) preparing an emplastrum matrix. The preparation method disclosed by the invention is simple, can realize quick release of the medicine, has an accumulated release rate obviously higher than that of a process sample of an original prescription, not only reduces resource waste, but also provides a feasible method for improving the potential curative effect of a product, and has remarkable social and economic benefits.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a preparation method of a patch base for rapid release of volatile drugs. Background technique [0002] The pain-removing fitness ointment is a well-known product in the market (such as Henan Lingrui Pharmaceutical Co., Ltd.'s original external patch preparation), which mainly treats rheumatism arthralgia, waist and leg pain, and swelling and pain caused by slumps and falls, that is, for the purpose of pain relief. The drug formula is: salvia 90-120g, safflower 90-120g, saffron 90-120g, gardenia 90-120g, weilingxian 45-65g, duhuo 45-65g, prickly ash 45-65g, borneol 130-165g , Camphor 90~120g, Menthol 90~120g. This recipe is formulated in accordance with the requirements of the monarch, minister, assistant and envoy under the guidance of the theory of traditional Chinese medicine: camphor is pungent and cool, can promote blood circulation, reduce swelling and relieve pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/32A61K47/06A61K47/10A61K47/14A61K36/758A61P29/00C08F297/04A61K31/045A61K31/125
CPCA61K9/7023A61K47/32A61K47/06A61K47/10A61K47/14A61K36/537A61K36/286A61K36/486A61K36/744A61K36/716A61K36/232A61K36/758A61K31/045A61K31/125A61P29/00C08F297/04A61K2300/00Y02A50/30
Inventor 熊伟郭立李磊卢玉斌张春霞高锡意杨春光
Owner HENAN LINGRUI PHARMA
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