Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation process of traditional Chinese medicine compound granules

A preparation process and granule technology, which is applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., to achieve the effects of increasing solubility, increasing stability, and reducing odor

Active Publication Date: 2022-07-15
GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Qingkailing granules currently have mature technology and quality standards, and the product quality is stable, but there is still potential for further improvement

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation process of traditional Chinese medicine compound granules
  • Preparation process of traditional Chinese medicine compound granules
  • Preparation process of traditional Chinese medicine compound granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] prescription:

[0035] 12 parts cholic acid, 200 parts mother of pearl, 15 parts hyodeoxycholic acid, 100 parts gardenia,

[0036] 100 parts of buffalo horn, 800 parts of isatidis, 20 parts of baicalin and 240 parts of honeysuckle.

[0037] Preparation Process:

[0038](1) Radix isatidis, gardenia and honeysuckle are mixed and extracted by boiling with water for 1 hour each time, the extracts are combined, concentrated to a clear paste with a relative density of 1.22-1.28 at 80°C, and filtered to obtain three mixed extracts.

[0039] (2) Buffalo horn milled powder, added to 4mol / L barium hydroxide solution, decocted for 7 hours, filtered while hot; mother-of-pearl was added to 4mol / L sulfuric acid solution, decocted for 7 hours, filtered while hot, and the filtrate After cooling, combine with buffalo horn filtrate, filter, let the filtrate be concentrated to twice the amount of the raw material, let it cool, add ethanol to make the alcohol content up to 60%, stir even...

Embodiment 2

[0045] prescription:

[0046] 13 parts of cholic acid, 200 parts of mother-of-pearl, 15 parts of hyodeoxycholic acid, 100 parts of gardenia,

[0047] 100 parts of buffalo horn, 800 parts of isatidis, 20 parts of baicalin and 240 parts of honeysuckle.

[0048] Preparation Process:

[0049] (1) Radix isatidis, gardenia and honeysuckle are mixed and extracted by boiling with water for 1 hour each time, the extracts are combined, concentrated to a clear paste with a relative density of 1.22-1.28 at 80°C, and filtered to obtain three mixed extracts.

[0050] (2) Buffalo horn milled powder, added to 4mol / L barium hydroxide solution, decocted for 7 hours, filtered while hot; mother-of-pearl was added to 4mol / L sulfuric acid solution, decocted for 7 hours, filtered while hot, and the filtrate After allowing to cool, combine with the filtrate of buffalo horn, filter, and let cool when the filtrate is concentrated to 3 times the amount of the raw material, add ethanol to make the alco...

Embodiment 3

[0056] prescription:

[0057] 13 parts of cholic acid, 200 parts of mother-of-pearl, 15 parts of hyodeoxycholic acid, 100 parts of gardenia,

[0058] 100 parts of buffalo horn, 800 parts of isatidis, 20 parts of baicalin and 240 parts of honeysuckle.

[0059] Preparation Process:

[0060] (1) Radix isatidis, gardenia and honeysuckle are mixed and extracted by boiling with water for 1 hour each time, the extracts are combined, concentrated to a clear paste with a relative density of 1.22-1.28 at 80°C, and filtered to obtain three mixed extracts.

[0061] (2) Buffalo horn milled powder, added to 4mol / L barium hydroxide solution, decocted for 7 hours, filtered while hot; mother-of-pearl was added to 4mol / L sulfuric acid solution, decocted for 7 hours, filtered while hot, and the filtrate After allowing to cool, combine with buffalo horn filtrate, filter, and let cool when the filtrate is concentrated to twice the amount of the raw material, add ethanol to make the alcohol conte...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation process of traditional Chinese medicine compound granules, which comprises the following steps: (1) adding water into isatis root, cape jasmine and honeysuckle flower, decocting, filtering decoction, and merging filtrate to obtain a triple-mixed extracting solution; (2) respectively grinding cornu bubali and nacre mother of pearl into powder, respectively decocting and filtering, combining filtrate, and carrying out inclusion by utilizing cyclodextrin to obtain mixed hydrolysate; (3) concentrating the three-mixed extracting solution and the mixed hydrolysate to obtain a five-mixed extract; (4) dispersing cholic acid and hyodeoxycholic acid by using mannitol to obtain mixed cholic acid dispersed powder or particles; (5) dispersing baicalin by using mannitol to obtain baicalin dispersed powder or particles; and (6) finally, uniformly mixing the five-mixed extract, the mixed cholic acid and the baicalin solid dispersion, adding auxiliary materials, drying, and preparing into granules. According to the new process, peculiar smell and bitter taste can be covered, the medication compliance of a patient is improved, and meanwhile the quality and stability of the Qingkailing granules are improved.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine granules, and particularly relates to a preparation process of traditional Chinese medicine compound granules. Background technique [0002] Chinese herbal medicines are made into traditional Chinese medicine forms such as pills, powders, pastes, and dan, but the disadvantages of large dosage, unstable quality and poor preservation have greatly restricted the development of Chinese medicine. The extraction and separation of active ingredients in Chinese herbal medicines is the key to improving the efficacy of traditional Chinese medicine, reducing adverse reactions and improving the internal quality of preparations. Chinese medicine granules refer to the solid preparations for oral administration prepared by extracting and concentrating medicinal materials with water or other solvents by suitable methods. It is a new dosage form developed and improved by using modern preparat...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/16A61K47/26A61K47/69A61K36/744A61P11/00A61P29/00A61P31/12A61P11/04A61K35/618A61K31/575A61K35/32A61K31/7048
CPCA61K9/1682A61K9/1623A61K47/6951A61K31/575A61K35/618A61K36/744A61K35/32A61K36/195A61K36/315A61K31/7048A61K36/355A61P11/00A61P29/00A61P31/12A61P11/04A61K2236/331A61K2236/39A61K2300/00
Inventor 陈红英谢正福王福坚潘碧妍邵妙霞谭观莲黎芷明
Owner GUANGZHOU BAIYUNSHAN MINGXING PHARM CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com