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Ceramic calcium phosphate bone cement and preparation method thereof

A technology for ceramizing calcium phosphate and bone cement, which can be used in bone implants, inorganic inactive ingredients, etc., can solve problems such as human tissue damage, and achieve the effects of strong mechanical properties, high chemical stability, and controllable degradability.

Active Publication Date: 2022-06-07
卢霄 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the solid phase used in the existing preparation of calcium phosphate bone cement is powder, and the calcium phosphate bone cement formed by the chemical reaction between powder and powder will degrade and produce many particles after planting into the human body, and these Particles trigger an inflammatory response that can cause damage to human tissue

Method used

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  • Ceramic calcium phosphate bone cement and preparation method thereof

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preparation example Construction

[0029] An embodiment of the present invention provides a preparation method of ceramized calcium phosphate bone cement, refer to figure 1 , figure 1 It is a flow chart of the preparation method of the ceramicized calcium phosphate bone cement according to an embodiment of the present invention, and the preparation method of the ceramicized calcium phosphate bone cement includes:

[0030] Step S1, preparing β-TCP ceramic particles;

[0031] Step S2, select distilled water as the liquid phase of the ceramic calcium phosphate bone cement;

[0032] In step S3, the ceramized calcium phosphate bone cement is obtained by using the β-TCP ceramic particles and the calcium dihydrogen phosphate powder to undergo self-solidification reaction in the liquid phase.

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Abstract

The invention provides ceramic calcium phosphate bone cement and a preparation method thereof. The preparation method of the ceramic calcium phosphate bone cement comprises the following steps: preparing beta-TCP ceramic particles; distilled water is selected as a liquid phase of the ceramic calcium phosphate bone cement; and carrying out self-curing reaction on the beta-TCP ceramic particles and monocalcium phosphate powder in the liquid phase to obtain the ceramized calcium phosphate bone cement. The plastic ceramic calcium phosphate bone cement and the injection ceramic calcium phosphate bone cement are respectively formed by adopting preparation processes of a mixing method and a blending method. According to the technical scheme, the ceramic calcium phosphate bone cement is higher in chemical stability, better in operability, higher in mechanical property and more controllable in degradability; and particularly, inflammatory response and damage to tissues and organs caused by the generation of the degraded particles can be avoided or reduced after the implant is implanted into a body.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a ceramicized calcium phosphate bone cement and a preparation method thereof. Background technique [0002] The ideal bone repair material should have good biocompatibility, non-toxic and harmless to the human body, or low toxicity; the material should be easy to shape to meet the needs of different transplant sites; suitable material microstructure to ensure tissue ingrowth and nutrient supply; able to It is gradually degraded and replaced by new bone in the body. Bone cement is one of the members of bone repair biomaterials, which forms self-curing through the physicochemical and chemical reactions of solid and liquid phases. Bone cement can be delivered to the target site through a small surgical incision or even percutaneous injection, which simplifies and minimises the treatment and promotes the recovery of patients. [0003] In the 1980s, Dr. Brown and Chow researched ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B28/34A61K47/02A61F2/28
CPCC04B28/344A61K47/02A61F2/28C04B14/366C04B22/16C04B22/062
Inventor 卢霄卢建熙刘欣莫秀梅范存义姚宸维高旭韦荣华
Owner 卢霄
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