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Composite probiotic composition for treating hyperuricemia and gout as well as preparation method and application thereof

A technology of compound probiotics and composition, applied in the field of probiotics, to achieve the effect of good gout symptoms, relief of gout symptoms, and lower blood uric acid level

Pending Publication Date: 2022-05-06
金华银河生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

my country lacks nationwide gout epidemiological survey data, but according to the prevalence of gout reported in different time and regions, the prevalence of gout in my country is 1% to 3%, and the prevalence of hyperuricemia is 13.3%. Rising year by year and younger trend

Method used

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  • Composite probiotic composition for treating hyperuricemia and gout as well as preparation method and application thereof
  • Composite probiotic composition for treating hyperuricemia and gout as well as preparation method and application thereof
  • Composite probiotic composition for treating hyperuricemia and gout as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] A compound probiotic bacteria powder, including Lactobacillus casei Zhang (Lactobacillus casei Zhang), Bifidobacterium animalis subsp.lactis V9, Lactobacillus plantarum P-8, Lactobacillus rhamnosus Probio-M9 (Lactobacillus rhamnosus Probio-M9) and Bifidobacterium lactis Probio-M8 (Bifidobacterium lactis Probio-M8).

[0058] The microorganism preservation number of the Lactobacillus casei Zhang (Lactobacillus casei Zhang) is CGMCCNo.5469;

[0059] The microorganism preservation number of Bifidobacterium animalis subsp. lactis V 9 is CGMCC No.5470;

[0060] The microorganism preservation number of Lactobacillus plantarum P-8 is CGMCCNo.6312;

[0061] The microbial deposit number of Lactobacillus rhamnosus Probio-M9 is CGMCC No.18639;

[0062] The microorganism preservation number of Bifidobacterium lactis Probio-M8 (Bifidobacterium lactis Probio-M8) is CGMCC No.18610.

[0063] The colony-forming unit ratio of Lactobacillus casei Zhang, Bifidobacterium animalis subsp. V...

experiment example 1

[0084] Experimental Example 1 Clinical research on the adjuvant treatment of HUA with compound probiotic powder

[0085] 1 Experimental method

[0086] 1.1 Bacterial strains contained in the composite probiotic powder prepared in Example 1

[0087] L.casei Zhang, L.plantarum P-8, B.lactis V9, B.lactis Probio-M8 and L.rhamnosus Probio-M9 were provided by Beijing Ketuo Hengtong Biotechnology Co., Ltd.

[0088] 1.2 Test grouping

[0089] 44 patients with hyperuricemia were randomly divided into probiotic group (30 people) and placebo group (14 people). The probiotic group was given 30 billion CFU of compound probiotic powder every day.

[0090] Blood samples were collected before treatment and at 12 weeks of treatment to analyze changes in blood uric acid levels and related metabolic syndrome indicators (total cholesterol, triglycerides, low-density lipoprotein) levels. For specific experimental procedures, see figure 1 .

[0091] 1.3 Patient inclusion and exclusion criteria...

experiment example 2

[0105] Experimental Example 2 Clinical effect of compound probiotic powder in adjuvant treatment of gout

[0106] 1. Volunteer inclusion criteria

[0107] A. Age 18-70 years old, gender is not limited;

[0108] B. Previous history of gout attacks;

[0109] C. Meet the 2015 Eular / ACR gout classification diagnostic criteria;

[0110] D. Serum uric acid is 475-750 μmol / L.

[0111] 2. Exclusion criteria for volunteers

[0112] A. Patients with gout or secondary hyperuricemia in the past two weeks;

[0113] B. Taking drugs that affect uric acid metabolism or excretion and cannot / cannot be stopped;

[0114] C. Abnormal liver and kidney function, white blood cell count, platelet count, and hemoglobin level;

[0115] D. Patients with poorly controlled blood pressure, type 1 diabetes or poorly controlled type 2 diabetes;

[0116] E. Patients with intestinal diseases such as active peptic ulcer and malignant tumor patients;

[0117] F. Patients who need to continue taking predni...

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Abstract

The invention provides a compound probiotic composition. The compound probiotic composition is prepared from lactobacillus casei, two bifidobacterium lactis strains, lactobacillus plantarum and lactobacillus rhamnosus. By analyzing the change of related indexes in the blood of the patient before and after intervention of the compound probiotic composition, the compound probiotic composition can achieve the effect of relieving or treating the hyperuricemia patient by reducing the blood uric acid level and related metabolic syndrome index level of the hyperuricemia patient.

Description

technical field [0001] The invention relates to the field of probiotics, in particular to a composite probiotic composition for treating hyperuricemia and gout, a preparation method and application thereof. Background technique [0002] Hyperuricemia (HUA) refers to the fasting blood uric acid level higher than 420 μmol / L twice on different days under a normal purine diet, which is called hyperuricemia. Asymptomatic hyperuricemia (Asymptomatic hyperuricemia, aHUA) refers to elevated serum uric acid levels, but no gout-related clinical symptoms (including arthritis, tophi or uric acid nephropathy, urinary tract stones, etc.), which belongs to the preclinical stage of gout. HUA is not only the biochemical basis of gout, but also closely related to many diseases, such as diabetes, hypertension, metabolic syndrome, kidney damage, stroke, myocardial infarction, etc. It has gradually developed into one of the core links of metabolic diseases that threaten human health. one. The ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61P19/06A61P13/12A23L33/135A61K35/745
CPCA61K35/747A61K35/745A61P19/06A61P13/12A23L33/135A23V2002/00A23V2400/125A23V2400/175A23V2400/515A23V2400/169A61K2300/00A23V2200/30A23V2250/206
Inventor 包维臣刘晓军张凌宇马杰杨慧娟
Owner 金华银河生物科技有限公司
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