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Microelement-loaded yeast micro-nano robot sugar pill and preparation method thereof

A technology of trace elements and robotic sugars, applied in the field of drug carriers, can solve problems such as limited absorption efficiency and difficulty in breaking through barriers, and achieve the effect of increasing drug delivery efficiency

Active Publication Date: 2022-04-29
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Yeast itself cannot move, it is difficult to break through the above barriers, and the absorption efficiency is limited

Method used

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  • Microelement-loaded yeast micro-nano robot sugar pill and preparation method thereof
  • Microelement-loaded yeast micro-nano robot sugar pill and preparation method thereof
  • Microelement-loaded yeast micro-nano robot sugar pill and preparation method thereof

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preparation example Construction

[0039] The present invention also provides a preparation method for the yeast micro-nano robot sugar pill loaded with trace elements, comprising the following steps:

[0040] (1) Mix the yeast cells with the medium, and incubate at 25°C-37°C for 0.5-1 hour to revive the yeast cells, make the yeast cells respire, and generate carbon dioxide inside the cells;

[0041] (2) After mixing the recovered yeast cells in step (1) with trace element salt solution, incubate at 25°C-37°C for 1-24 hours for biomineralization to obtain yeast cells loaded with trace elements; The mass ratio of the salt solution of element is preferably 1:(10-100);

[0042] (3) Mix the yeast cells carrying trace elements and the masking agent evenly, then pour them into a plate, dry, and then wash with ultrapure water three times to remove the excess masking agent to obtain partially masked yeast cells; The mass ratio of yeast cells to masking agent is 1: (0.01-0.25).

[0043] (4) The activator is added to t...

Embodiment

[0047] A yeast micro-nano robot sugar pill loaded with trace elements is characterized in that it includes an external polysaccharide shell and at least one yeast micro-nano robot inside, wherein the yeast micro-nano bio-robot is partially covered by yeast cells The biological enzymes on the yeast cells and the trace elements loaded inside the yeast cells are composed.

[0048] In some specific embodiments, the composition of the polysaccharide shell can be one or more of lactose, maltose, sucrose, dextrin, starch, fructose, xylose, and microcrystalline cellulose. These polysaccharides can be degraded in vivo, so that the yeast micro-nano robots inside the capsid can be released.

[0049] In some specific embodiments, the trace element is one or more of calcium, iron, zinc, selenium, copper, molybdenum, chromium, cobalt, iodine, fluorine, and manganese, which can meet the needs of the body for different types of trace elements .

[0050] A preparation method of yeast micro-n...

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Abstract

The invention provides a trace element-loaded yeast micro-nano robot sugar pill, which is characterized by comprising an external polysaccharide coat and at least one internal yeast micro-nano robot, the yeast micro-nano biological robot is composed of yeast cells, biological enzyme and trace elements, wherein the yeast cells are half-covered with the biological enzyme, and the trace elements are loaded in the yeast cells. The polysaccharide coat of the yeast micro-nano robot sugar pill can be degraded in the intestinal tract to release a yeast micro-nano robot carrying trace elements, and the yeast micro-nano robot can utilize glucose in the intestinal tract as power to autonomously move, so that the yeast micro-nano robot can penetrate through mucus barriers, epithelial barriers and other barriers to reach the intestinal wall, and absorption of the organism to the trace elements is efficiently promoted.

Description

technical field [0001] The invention belongs to the technical field of drug carriers, and in particular relates to a yeast micro-nano robot sugar pill loaded with trace elements and a preparation method thereof. Background technique [0002] Although the proportion of trace elements in the human body is very small, they play a huge role in human physiological activities. Long-term lack of trace elements can lead to various diseases. Such as iron deficiency anemia, iodine deficiency caused by cretinism and endemic goiter, selenium deficiency caused by low immunity and so on. Excessive intake of trace elements can also cause diseases, so efficient and accurate intake of trace elements is very important. Studies have shown that direct supplementation of inorganic trace elements not only has low activity, but also has a short residence time in the body. Therefore, the supplementation efficiency of trace elements is low, and the dosage cannot be precisely controlled. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/26A61K47/36A61K47/38A61K47/69A61K47/62A61K45/00A61K47/46A61P3/02
CPCA61K9/5036A61K9/5042A61K47/6901A61K47/62A61K9/0053A61K45/00A61K47/46A61P3/02
Inventor 蔡林涛张保珍郑明彬潘宏马爱青陈泽
Owner SHENZHEN INST OF ADVANCED TECH
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