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Drop pills of fine powder of dragons blood, and preparation method

A technology for powder dripping pills and dried blood, which is applied in the field of medicine, can solve the problems of low degree of pure naturalness, low degree of naturalness, and low degree of naturalness of excipients for dripping pills, so as to reduce the irritating smell of drugs, improve the pH of the oral cavity, and improve the The effect of mouth odor

Inactive Publication Date: 2006-12-06
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Dropping pills is a drug preparation with fast onset of action, application number: 03123013.X, application date: 2003.4.26, applicant: Nanchang Hongyi Technology Co., Ltd., name of invention: Xuejie dropping pills and its preparation method - removing stasis Dingtong, the patent document of hemostasis and muscle regeneration provides a kind of drop pill preparation and preparation method thereof, and this drop pill medicine uses polyethylene glycol and other adjuvants to make blood dried blood fine powder into drop pill; The defect of speeding up the dissolution rate, but the drop pill has the defect that the natural degree of the excipients used is not high
[0004] With the global expansion of the market and the requirement of human beings to return to nature, the use of drugs with low toxicity and side effects, especially pure natural drugs, has become the first choice of people. The preparation is a kind of high-efficiency, quick-acting new Chinese medicine preparation, which overcomes the shortcomings and deficiencies of the previous Chinese medicine preparations, but the current drop pill preparations generally face the following problems: 1. The natural degree of drop pill auxiliary materials is not high: at present, the drop pill matrix Most of the excipients are chemical synthetic products with a low degree of naturalness. It is very difficult to find new alternative matrix excipients, especially the search for alternative matrix excipients with a high degree of naturalness and the determination of their preparation process, because currently common and possible The preparation conditions required for the substitutes of natural matrix excipients are very harsh, and the temperature of excipients and the droplet dripping conditions are the key factors affecting the preparation of droplet pills
If the melting temperature of the excipient is too high, the viscosity will be low and the plasticity will be poor. If the melting temperature of the excipient is too low, although the plasticity is strong, the dropping pills have disadvantages such as easy sticking and deformation. The accessories are very hard work
2. Problems encountered in the export of dripping pills: With the development of the economy, the market is becoming more and more internationalized, and China is also trying to adapt to this trend. Currently, Chinese medicine dripping pills, which are used as health food, have been successfully exported to many countries, but There are also many problems at present, because different countries have different approvals for the excipients selected for the preparation of Chinese medicine dripping pills, especially in Europe with developed industries, which have stricter regulations on food excipients and pharmaceutical excipients, and the drops exported as health food The chemically synthesized auxiliary materials (such as polyethylene glycol) selected for pill preparations are not listed in the food additive catalogs of some countries, which is very unfavorable for Chinese medicine dripping pill preparations to enter the international market, and has become a stumbling block for Chinese medicine to enter the international market. Therefore, looking for One or more new matrix excipients that can be accepted by the international market are particularly important and urgent
3. Disadvantages of mouthfeel and speed of onset of action: Poor taste of traditional Chinese medicine and its preparations is one of its major characteristics. When people take certain medicines, they are far more afraid of the bad taste of the medicine than they are of the disease. What's more, some patients give up the treatment of traditional Chinese medicine because they can't overcome the bad taste or smell of traditional Chinese medicine or its preparations. For example, making the medicine into capsules or sugar-coated tablets can improve the taste and reduce stimulation, but the disintegration speed is prolonged. , which is not conducive to the rapid onset of the drug, and is not suitable for some diseases, especially those that require the rapid onset of the drug
4. Difficult preparation process for industrial production of dripping pills: In the replacement process of dripping pill preparation auxiliary materials, it is very difficult to determine the preparation process for industrial production, such as the melting temperature of matrix auxiliary materials, dripping temperature, auxiliary materials and The ratio of the drug, the ratio of the caliber of the dropper, and the condensing agent are all factors that affect the drop pills. Therefore, it is time-consuming and expensive to replace the matrix and be suitable for industrial production.
[0005] In order to change the long-term situation that the base excipients of drop pills are mainly chemically synthesized excipients, and solve the problem that the base of drop pills is currently facing a low level of naturalness, it is increasingly unable to meet people's requirements for returning to nature, taking pure natural medicines with low toxicity and no side effects Problems: It can also solve some problems encountered in the export process of Chinese medicine preparations, especially dripping pill preparations, and enhance the competitiveness of the international market; the present invention has invented a toxic and side effect medicine through a large number of experiments and research on preparation technology. Pure Chinese medicine dripping pill preparation with low cost, significant curative effect, moderate price, and suitable for industrialized large-scale production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (a) Take 6.0 g of Dragon's Blood powder, 18.3 g of xylitol, and 6.7 g of starch for use;

[0052] (b) Take xylitol and starch and mix evenly, add the above-mentioned dragon blood powder and mix thoroughly, heat and melt the mixture at 64°C, stir evenly, stirring time is 10-30 minutes, keep warm, drip and drop at 64°C The caliber is 1.2-2.5 mm, and it is dripped into methyl silicone oil at 0°C to make 1000 droplets. The droplets are drained and the coolant is wiped off to get it.

Embodiment 2

[0054] (a) Take 20g of Dragon's Blood powder, 76.9g of lactitol and 23.1g of starch for use;

[0055] (b) Take lactitol and starch and mix evenly, add the above-mentioned dragon's blood powder and mix thoroughly, heat and melt the mixture at 64°C, stir evenly, stirring time is 10-30 minutes, keep warm, drip at 64°C, dropper diameter The diameter is 1.2 ~ 2.5 mm, and it is dripped into methyl silicone oil at 0°C to make 3000 drop pills. Drain the drop pills and wipe off the cooling liquid to get it.

Embodiment 3

[0057] (a) Take 40g of Dragon's Blood powder, 71.4g of xylitol, and 28.6g of gum arabic for use;

[0058] (b) Take xylitol and gum arabic and mix well, add the above-mentioned dragon blood powder and mix thoroughly, heat and melt the mixture at 64℃, stir evenly, stirring time is 10-30 minutes, keep warm, drip and drip at 64℃ The diameter of the tube is 1.2-2.5 mm, and it is dripped into methyl silicone oil at 0°C to make 4000 droplets. The droplets are drained and the coolant is wiped off to get it.

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Abstract

A dripping pill of Dragon's blood for treating coronary heart disease features high natural level and safety and low toxic by-effect. Its preparing process is also disclosed.

Description

Technical field [0001] The present invention relates to the field of medicine, in particular, to a medicine for treating coronary heart disease made from Dragon's blood as a raw material. Background technique [0002] Dragon's blood, also known as Kylin's Dragon, was first published in the "Lei Gong Cannon Burning Theory" during the Northern and Southern Dynasties. It has been used as a traditional Chinese medicine for more than 1,500 years in my country. It is made from the resin exuded from the fruit of the palm family Daemonorops dracoB1. Nature and flavor are sweet, successful, and flat. Guixin, Liver Channel. It has the effects of dispelling blood stasis and relieving pain, stopping bleeding and promoting muscle growth. It is used for falling and falling, internal injuries and bruising pain; traumatic bleeding is not stopped. Under normal circumstances, it is taken internally, or into pills, or powdered into powder, or into plasters for externa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61K9/20A61P7/04A61P9/06A61P9/10A61P17/02A61P19/08A61K131/00
Inventor 李永强郑永锋
Owner TIANJIN TASLY PHARMA CO LTD
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