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Antibacterial and anti-adhesion nanofiber dressing free of bandage fixation and preparation method of antibacterial and anti-adhesion nanofiber dressing

A nanofiber and nanofiber membrane technology, applied in bandages, medical science, non-woven fabrics, etc., can solve the problems of waste of natural cotton fiber resources, difficult to maintain wound moisturization, and poor control of drug dosage, so as to reduce the pain of dressing changes. The effect of increasing the comfort of contact and reducing the frequency of replacement

Active Publication Date: 2022-04-08
YANCHENG INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to provide a kind of antibacterial and anti-adhesion nanofiber dressing and its preparation method exempt from bandage fixation, to overcome the natural cotton existing in existing dressing products. Waste of fiber resources, difficulty in keeping the wound surface moist, poor air permeability, poor control of drug dosage, re-damage of tissue during dressing change, etc.

Method used

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  • Antibacterial and anti-adhesion nanofiber dressing free of bandage fixation and preparation method of antibacterial and anti-adhesion nanofiber dressing
  • Antibacterial and anti-adhesion nanofiber dressing free of bandage fixation and preparation method of antibacterial and anti-adhesion nanofiber dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] S1, the preparation of nuclear layer spinning solution: firstly disperse the drug—silver sulfadiazine ultrasonically into an aqueous dispersion with a mass concentration of 10wt%, then mix cyclodextrin and ethyl cellulose in a mass ratio of 1:2 and use a volume ratio The mixed solution of 1:1 ethanol and water is used as a solvent to dissolve, and after sealing, it is fully mixed and stirred for 6 hours until uniform, and then the mixed solution with a mass concentration of 10wt% medicinal solution and 10wt% cyclodextrin-ethyl cellulose is mixed at a ratio of 1:5 The volume ratio is fully mixed and stirred until uniform, and used as the core layer spinning solution.

[0039] S2, preparation of shell spinning solution: dissolving chitosan powder and gelatin powder in acetic acid solution with the same mass concentration, then miscible with equal volume ratio of 1:1, sealed and fully stirred at room temperature, finally A chitosan-gelatin mixed solution with a solid mass ...

Embodiment 2

[0046] The difference from Example 1 is that the medicine is different, which is chloramphenicol, and the concentration of the drug solution dissolved in alcohol is 20wt%. The others are the same as in Example 1, and an antibacterial and anti-adhesion nanofiber dressing without bandage fixing is obtained.

[0047] The antibacterial and anti-adhesion nanofiber dressing prepared in this embodiment without bandage fixation has the following advantages: the diameter of a single fiber is 300-500 nm, the thickness is 800-1000 μm, it has a natural nanofiber and nanopore structure, and it is lighter, thinner and more breathable than cotton gauze. The combination with the skin is firm, and the contact comfort with the skin is increased, and 12 layers can be superimposed and covered. Suitable for wounds with exudate, PBS aqueous solution with a pH of 7.4 is used as a simulated body fluid, 2mL of PBS aqueous solution is completely absorbed in 6s, and quickly forms a gel in 15s. The dress...

Embodiment 3

[0049] The difference from Example 1 is that the medicine is different, it is ketoprofen, and the concentration of the drug solution dissolved in alcohol is 20wt%. Others are the same as in Example 1, and an antibacterial and anti-adhesion nanofiber dressing without bandage fixing is obtained.

[0050] The antibacterial and anti-adhesion nanofiber dressing prepared in this embodiment without bandage fixation has the following advantages: the diameter of a single fiber is 300-500 nm, the thickness is 800-1000 μm, it has a natural nanofiber and nanopore structure, and it is lighter, thinner and more breathable than cotton gauze. The combination with the skin is firm, and the contact comfort with the skin is increased, and 11 layers can be superimposed and covered. Suitable for wounds with exudate, PBS aqueous solution with a pH of 7.4 is used as the simulated body fluid, 2mL of PBS aqueous solution is completely absorbed in 8s, and quickly forms a gel in 13s. The dressing has a ...

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Abstract

The invention relates to an antibacterial and anti-adhesion nanofiber dressing free of bandage fixation and a preparation method of the antibacterial and anti-adhesion nanofiber dressing. The dressing is a core-shell structure nanofiber membrane with a mixture of cyclodextrin and ethyl cellulose loaded with anti-inflammatory and antibacterial drugs as a core layer and a mixture of chitosan and gelatin as a shell layer. The method comprises the following steps: mixing a cyclodextrin-ethyl cellulose mixed solution with an anti-inflammatory and antibacterial drug solution to obtain a core layer spinning solution; mixing the chitosan solution and the gelatin solution to obtain a shell spinning solution; and carrying out coaxial electrostatic spinning on the core layer spinning solution and the shell layer spinning solution. The dressing has the advantages of good gelling property, long-acting drug release property, anti-adhesion property and the like.

Description

technical field [0001] The invention belongs to the field of medical dressings and preparation thereof, in particular to an antibacterial and anti-adhesion nanofiber dressing without bandage fixation and a preparation method thereof. Background technique [0002] People will experience various wounds or burns during their daily life and work. If the wound is not treated properly, it is easy to cause infection, slow healing, and scars. Traditional dressings include ordinary gauze, absorbent cotton, cotton pads, etc. On the one hand, these materials are taken from natural cotton, and discarding them after one use will cause waste of resources; on the other hand, these dressings mostly play an isolation role, in order to promote wound healing and In order to effectively control wound infection, antibiotics and other medications are required clinically. However, even with combined medication, there are still many limitations, such as difficulty in keeping the wound moist, poor ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/32A61L15/20A61L15/44A61L15/46D04H1/42D04H1/728
CPCY02A50/30
Inventor 林洪芹吴焕岭郭岭岭周天池
Owner YANCHENG INST OF TECH
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